Comparing different estimated glomerular filtration rate equations in assessing glomerular function in children based on creatinine and cystatin C

Çonkar, Seçil; Mır, Sevgı; Karaslan, Fatma Nur; Hakverdi, Gülden

doi:10.1002/jcla.22413

Cited by 6 publications

(11 citation statements)

References 27 publications

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“…Proteinuria and eGFR are common indicators for renal function ( Jha et al, 2013 ; Conkar et al, 2018 ). Proteinuria is often found in patients with CKD.…”

Section: The Potential Biomarkers Related To Ckdmentioning

confidence: 99%

A Novel Perspective Linkage Between Kidney Function and Alzheimer’s Disease

Shi

Liu

Shen

et al. 2018

Front. Cell. Neurosci.

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It has long been believed that kidney function is linked to brain activity. Clinical studies demonstrate that patients with chronic kidney disease (CKD) are more prone to cognitive impairment and Alzheimer’s disease (AD), and the degree of cognitive impairment is closely related to CKD progression and renal failure. Moreover, the fact that cognitive function in CKD patients is significantly improved after successful kidney transplantation reveals a linkage between CKD and AD. However, the mechanisms behind this linkage are unclear. The physiological function of the kidney is to maintain the stability of the internal environment, including the cerebrovascular circulation, whereas abnormal kidney function often leads to ischemia and hypoxia. Many CKD patients experience chronic hypoxia, and many urinary toxins accumulate after renal function is impaired. In this mini review, we will propose a novel perspective on the association between AD and CKD and the connection between the kidney and brain.

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“…Proteinuria and eGFR are common indicators for renal function ( Jha et al, 2013 ; Conkar et al, 2018 ). Proteinuria is often found in patients with CKD.…”

Section: The Potential Biomarkers Related To Ckdmentioning

confidence: 99%

A Novel Perspective Linkage Between Kidney Function and Alzheimer’s Disease

Shi

Liu

Shen

et al. 2018

Front. Cell. Neurosci.

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“…The original Schwartz equations, initially developed in 1976 and subsequently refined, have long been a cornerstone in estimating glomerular filtration rate (eGFR) in pediatric populations. In 2009, Schwartz et al developed a revised estimated GFR formula using data from a cohort of children in the Chronic Kidney Disease in Children (CKiD) study [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…Based on serum creatinine (S Cr ) levels and patient demographics, these equations provide a practical means of assessing renal function, particularly in clinical settings where direct measurement of GFR is challenging. However, their reliance on creatinine levels, which can be influenced by factors such as muscle mass and diet, has prompted scrutiny regarding their accuracy, especially in certain patient populations [6,8].…”

Section: Introductionmentioning

confidence: 99%

A Pilot Comparative Study between Creatinine- and Cystatin-C-Based Equations to Estimate GFR and Kidney Ultrasound Percentiles in Children with Congenital Anomalies of the Kidney and Urinary Tract

Steflea,

Stroescu,

Gafencu

et al. 2024

Diagnostics

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Congenital anomalies affecting the kidneys present significant challenges in pediatric nephrology, needing precise methods for assessing renal function and guiding therapeutic intervention. Bedside Schwartz formula with the cystatin-C-based Full Age Spectrum formula and Chronic Kidney Disease in Children (CKiD) U 25 formula used in estimating glomerular filtration rate (eGFR) and also to assess if the eGFR in association with kidney length percentiles can be a monitoring parameter for the progression of chronic kidney disease in children with congenital anomalies of the kidney and urinary tract (CAKUT). A total of 64 pediatric patients (median age at diagnostic was 12 months with an interquartile range of 2 to 60) were diagnosed with congenital anomalies in the kidney and urinary tract between June 2018 and May 2023 at “Louis Turcanu” Emergency Hospital for Children in Timisoara, Romania. Baseline characteristics, CAKUT types, associated pathologies, CKD staging, and eGFR using creatinine and cystatin C were analyzed. The mean age at the moment of examination was 116.50 months; (65, 180). Chronic kidney disease staging revealed a predominance of patients in CKD stages G1 and A1. Analysis of eGFR methods revealed a small mean difference between eGFR estimated by creatinine and cystatin C, with a moderate-strong positive correlation observed between the eGFR and ultrasound parameters. Using cystatin-C-based formulas for eGFR, in conjunction with ultrasound measurements, may offer reliable insights into renal function in pediatric patients with congenital anomalies affecting the kidney and urinary tract. However, the economic aspect must be taken into consideration because cystatin C determination is approximately eight times more expensive than that of creatinine. An interdisciplinary approach is crucial for managing patients with CAKUT.

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“…Therefore, it is recommended to calculate the estimated glomerular filtration rate (eGFR). 14 And eGFR is considered to be a simple, rapid and reliable indicator in evaluating renal function. Furthermore, sCr is an integral part of screening for chronic kidney disease (CKD).…”

Section: Introductionmentioning

confidence: 99%

Sensitive Detection of Serum Creatinine Based on β-Cyclodextrin-Ferrocenylmethanol Modified Screen-printed Electrode

Liu

et al. 2019

ANAL. SCI.

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Ferrocenylmethanol (Fc-OH) is included in β-cyclodextrin (β-CD) to form the β-CD-Fc-OH complex by host-guest supramolecular interaction. β-CD dissociates from the β-CD-Fc-OH complex due to the conversion of Fc-OH to Fc +-OH under a stimulus of oxidant. In our study, Fc-OH is oxidized after a series of enzymatic reactions of creatinine, which blocks the other means for oxidation of Fc-OH. And the background noise is reduced for testing for serum creatinine (sCr). The chronoamperometry signal for creatinine (with a constant potential-0.3 V vs. Ag/AgCl) increases linearly in the 1-1000 μM range, with a limit of detection as low as 0.5 μM. The amperometric potential of-0.3 V greatly prevents the interference of various redox substances in serum. The biosensor was used to test 120 clinical specimens and the results showed a linear correlation with the biochemical analyzer (R 2 = 0.9885). The biosensor could be applied to clinical trials and offers good prospects for clinical sCr detection.

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Comparing different estimated glomerular filtration rate equations in assessing glomerular function in children based on creatinine and cystatin C

Cited by 6 publications

References 27 publications

A Novel Perspective Linkage Between Kidney Function and Alzheimer’s Disease

A Novel Perspective Linkage Between Kidney Function and Alzheimer’s Disease

A Pilot Comparative Study between Creatinine- and Cystatin-C-Based Equations to Estimate GFR and Kidney Ultrasound Percentiles in Children with Congenital Anomalies of the Kidney and Urinary Tract

Sensitive Detection of Serum Creatinine Based on β-Cyclodextrin-Ferrocenylmethanol Modified Screen-printed Electrode

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