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citations
Cited by 248 publications
(315 citation statements)
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References 59 publications
(86 reference statements)
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“…S2a–d). It is well documented that GH‐resistant mice have more adiposity compared to control mice fed standard chow (Berryman et al ., 2004), and here, similarly we show that GH‐deficient Ames dwarf mice fed STD have more body fat compared to control mice fed STD. The normalized (percentage) total adipose tissue in relation to total body weight was higher in Ames dwarf mice fed STD compared to control mice fed either STD or HFD ( P  < 0.008), yet Ames dwarf mice fed HFD did not differ from Ames dwarf fed STD ( P  = 0.1810) (Fig.…”
Section: Resultssupporting
confidence: 82%
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“…S2a–d). It is well documented that GH‐resistant mice have more adiposity compared to control mice fed standard chow (Berryman et al ., 2004), and here, similarly we show that GH‐deficient Ames dwarf mice fed STD have more body fat compared to control mice fed STD. The normalized (percentage) total adipose tissue in relation to total body weight was higher in Ames dwarf mice fed STD compared to control mice fed either STD or HFD ( P  < 0.008), yet Ames dwarf mice fed HFD did not differ from Ames dwarf fed STD ( P  = 0.1810) (Fig.…”
Section: Resultssupporting
confidence: 82%
“…Previous studies have indicated that long‐lived mice that either are GH‐deficient or exhibit disrupted GH signaling have increased adiposity and systemic high levels of adiponectin (Berryman et al ., 2004; Wang et al ., 2006). The removal of epididymal visceral fat decreased levels of adiponectin and reduced insulin sensitivity in GHR‐KO and Ames dwarf mice (Masternak et al ., 2012; Menon et al ., 2014).…”
Section: Resultsmentioning
confidence: 99%
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“…The subcutaneous (inguinal) and visceral (mesenteric) fat pads were the most impacted, while the epididymal fat pad was least altered with growth hormone treatment. Depot-specific effects of growth hormone have been reported previously [21,22]. Thus, these data further support the notion that all fat depots should be evaluated independently in studies with growth hormone or other hormonal treatments.…”
Section: Discussionsupporting
confidence: 81%