Comparative Treatment of Experimental Staphylococcus epidermidis Endophthalmitis

Effect of caffeic acid phenethyl ester on treatment of experimentally induced methicillin‐resi̇stant Staphylococcus epidermidis endophthalmitis in a rabbit model

“…These results show that the efficacy of CAPE is comparable to steroids. As none of the vitreous samples showed any growth according to the culture results, these findings support the occurrence of 'auto-sterilization' of S. epidermidis in the rabbit model reported by Meredith et al 33 They demonstrated a spontaneous resolution of active bacterial replication, independent of initial inoculum size, within 1 week after intravitreal bacterial injection, suggesting the accumulation of inhibitor proteins and white cells, or the changes in the vitreous character itself might explain this spontaneous sterilization. Also, Smith et al 4 previously reported that all aspirates taken at 1 week after inoculation were culture-negative in a rabbit model of MRSE endophthalmitis.…”

Effect of caffeic acid phenethyl ester on treatment of experimentally induced methicillin‐resi̇stant Staphylococcus epidermidis endophthalmitis in a rabbit model

“…These results show that the efficacy of CAPE is comparable to steroids. As none of the vitreous samples showed any growth according to the culture results, these findings support the occurrence of 'auto-sterilization' of S. epidermidis in the rabbit model reported by Meredith et al 33 They demonstrated a spontaneous resolution of active bacterial replication, independent of initial inoculum size, within 1 week after intravitreal bacterial injection, suggesting the accumulation of inhibitor proteins and white cells, or the changes in the vitreous character itself might explain this spontaneous sterilization. Also, Smith et al 4 previously reported that all aspirates taken at 1 week after inoculation were culture-negative in a rabbit model of MRSE endophthalmitis.…”

The Efficacy of Intravitreal Levofloxacin and Intravitreal Dexamethasone in Experimental <i>Staphylococcus epidermidis</i> Endophthalmitis

“…The combination of dexamethasone to the treatment did not affect the clinical scores but its benefit in preserving the ocular architecture, though not statistically significant, is demonstrated. Also, similar to the study of Meredith et al [23], the continuation of inflammation is designated in our study both with clinical and histopathological scores, although the culture results are sterile. However, the efficacy of levofloxacin in the treatment of infectious endophthalmitis is not clearly proven.…”

Expression of TNF-α, IL-1β, and IFN-γ in Staphylococcus epidermidis slime-positive experimental endophthalmitis is closely related to clinical inflammatory scores

“…Rabbits have shown a similar capacity in eradicating bacteria [14]. Results demonstrated that S. epidermidis not only declines in number, but the vitreous cavity is sterile in almost all cases tested after 72 h [18]. This observation was confirmed in our study, since clinical inflammation in the experimental group gradually regressed after the 24-h time point and was almost abolished by day 7 post-injection.…”

“…Similar findings have been described in EIU in the rabbit caused by intravitreal injection of LPS, with inflammatory cells continuing to extravasate at 24 h [12]. Moreover, in experimentally induced S. epidermidis endophthalmitis in the aphakic rabbit eye, at 24 h after the inoculation of bacteria, all eyes had shown signs of clinical infection [18].…”

Effect of caffeic acid phenethyl ester on treatment of experimentally induced methicillin‐resi̇stant Staphylococcus epidermidis endophthalmitis in a rabbit model

“…These results show that the efficacy of CAPE is comparable to steroids. As none of the vitreous samples showed any growth according to the culture results, these findings support the occurrence of 'auto-sterilization' of S. epidermidis in the rabbit model reported by Meredith et al 33 They demonstrated a spontaneous resolution of active bacterial replication, independent of initial inoculum size, within 1 week after intravitreal bacterial injection, suggesting the accumulation of inhibitor proteins and white cells, or the changes in the vitreous character itself might explain this spontaneous sterilization. Also, Smith et al 4 previously reported that all aspirates taken at 1 week after inoculation were culture-negative in a rabbit model of MRSE endophthalmitis.…”

The Efficacy of Intravitreal Levofloxacin and Intravitreal Dexamethasone in Experimental <i>Staphylococcus epidermidis</i> Endophthalmitis

“…The combination of dexamethasone to the treatment did not affect the clinical scores but its benefit in preserving the ocular architecture, though not statistically significant, is demonstrated. Also, similar to the study of Meredith et al [23], the continuation of inflammation is designated in our study both with clinical and histopathological scores, although the culture results are sterile. However, the efficacy of levofloxacin in the treatment of infectious endophthalmitis is not clearly proven.…”

Expression of TNF-α, IL-1β, and IFN-γ in Staphylococcus epidermidis slime-positive experimental endophthalmitis is closely related to clinical inflammatory scores

“…Rabbits have shown a similar capacity in eradicating bacteria [14]. Results demonstrated that S. epidermidis not only declines in number, but the vitreous cavity is sterile in almost all cases tested after 72 h [18]. This observation was confirmed in our study, since clinical inflammation in the experimental group gradually regressed after the 24-h time point and was almost abolished by day 7 post-injection.…”

“…Similar findings have been described in EIU in the rabbit caused by intravitreal injection of LPS, with inflammatory cells continuing to extravasate at 24 h [12]. Moreover, in experimentally induced S. epidermidis endophthalmitis in the aphakic rabbit eye, at 24 h after the inoculation of bacteria, all eyes had shown signs of clinical infection [18].…”

Effect of caffeic acid phenethyl ester on treatment of experimentally induced methicillin‐resi̇stant Staphylococcus epidermidis endophthalmitis in a rabbit model

“…These results show that the efficacy of CAPE is comparable to steroids. As none of the vitreous samples showed any growth according to the culture results, these findings support the occurrence of 'auto-sterilization' of S. epidermidis in the rabbit model reported by Meredith et al 33 They demonstrated a spontaneous resolution of active bacterial replication, independent of initial inoculum size, within 1 week after intravitreal bacterial injection, suggesting the accumulation of inhibitor proteins and white cells, or the changes in the vitreous character itself might explain this spontaneous sterilization. Also, Smith et al 4 previously reported that all aspirates taken at 1 week after inoculation were culture-negative in a rabbit model of MRSE endophthalmitis.…”

The Efficacy of Intravitreal Levofloxacin and Intravitreal Dexamethasone in Experimental <i>Staphylococcus epidermidis</i> Endophthalmitis

“…The combination of dexamethasone to the treatment did not affect the clinical scores but its benefit in preserving the ocular architecture, though not statistically significant, is demonstrated. Also, similar to the study of Meredith et al [23], the continuation of inflammation is designated in our study both with clinical and histopathological scores, although the culture results are sterile. However, the efficacy of levofloxacin in the treatment of infectious endophthalmitis is not clearly proven.…”

Expression of TNF-α, IL-1β, and IFN-γ in Staphylococcus epidermidis slime-positive experimental endophthalmitis is closely related to clinical inflammatory scores

“…Rabbits have shown a similar capacity in eradicating bacteria [14]. Results demonstrated that S. epidermidis not only declines in number, but the vitreous cavity is sterile in almost all cases tested after 72 h [18]. This observation was confirmed in our study, since clinical inflammation in the experimental group gradually regressed after the 24-h time point and was almost abolished by day 7 post-injection.…”

“…Similar findings have been described in EIU in the rabbit caused by intravitreal injection of LPS, with inflammatory cells continuing to extravasate at 24 h [12]. Moreover, in experimentally induced S. epidermidis endophthalmitis in the aphakic rabbit eye, at 24 h after the inoculation of bacteria, all eyes had shown signs of clinical infection [18].…”