Comparative Toxicity of Five Commonly Used Analgesics on Rat Sperm Count and Sperm Morphology

Ekaluo, U. B.; Udokpoh, Aniekan E.; Udofia, Udeme Uyom; Ajang, Raymond

doi:10.4314/gjpas.v11i1.16465

Cited by 11 publications

(13 citation statements)

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“…The suspension was filtered using an 80 µm stainless mesh. Epididymal sperm count was obtained by cytometry using the improved Neubauer cytometer and was expressed as million/mL of suspension (Ekaluo et al, 2005).…”

Section: Epididymal Sperm Countmentioning

confidence: 99%

Effect of Aqueous Extract of Tigernut (Cyperus esculentus L.) on Sperm Parameters and Testosterone Level of Male Albino Rats

Ekaluo¹,

Ikpeme²,

Etta³

et al. 2014

Asian J. of Biotechnology

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Tigernut is consumed by humans and livestock. It also has many medicinal uses. There is growing evidence of decline in human sperm count and quality. Hence, this study seeks to evaluate the effect of Aqueous Extract of Tigernut (AET) on testosterone level, weight of epididymes and testes, sperm count, semen pH, sperm motility, sperm viability and sperm head abnormalities in male rats as a model. The rats were divided into four groups of six rats each. The rats were treated with AET at 0.0, 0.6, 1.2 and 1.8 g kgG 1 b.wt. dayG 1 , respectively for nine weeks. After which, the rats were sacrificed and assessed for the parameters. The AET had a dose-dependent effect on all the parameters. In conclusion, AET has the capability of increasing the weights of the testes and epididymes, sperm count, sperm quality and testosterone level. Hence, AET could be used as a possible fertility booster and to attenuate sperm toxicity.

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Section: Epididymal Sperm Countmentioning

confidence: 99%

Effect of Aqueous Extract of Tigernut (Cyperus esculentus L.) on Sperm Parameters and Testosterone Level of Male Albino Rats

Ekaluo¹,

Ikpeme²,

Etta³

et al. 2014

Asian J. of Biotechnology

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“…Unlike most other psychoactive substances, it is legal and unregulated in most part of the world (Ekaluo et al, 2005(Ekaluo et al, , 2009Craig, 2008) with an estimated 80% of the world's population consuming a caffeine-containing substance daily (Best, 1999;Craig, 2008). Caffeine dependency has a wide range of unpleasant physical and mental conditions such as nervousness, irritability, restlessness, insomnia, headache and heart palpitations (Lanch et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Consumption of caffeine has also been linked with delayed conception (Bolumar et al, 1997), reproductive and developmental toxicities (Ekaluo et al, 2013c(Ekaluo et al, , d, 2014 and increase in the frequency of sperm abnormalities (Robbins et al, 1997;Ekaluo et al, 2005Ekaluo et al, , 2009). …”

Section: Introductionmentioning

confidence: 99%

Protective Role of Aqueous Guava Leaf Extract Against Caffeine Induced Spermatotoxicity in Albino Rats

Ekaluo¹,

Ikpeme²,

Uno³

et al. 2016

Research J. of Medicinal Plant

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This study investigated the protecting potential of Aqueous Guava (Psidium guajava) Leaf Extract (AGLE) against caffeine induced spermatotoxicity in albino rat models. Thirty healthy and sexually matured albino rats were divided into five groups of six rats each using a completely randomized design. They were treated with caffeine and AGLE combinations orally for 65 days. The result showed that caffeine significantly (p<0.05) reduced sperm viability, sperm count and sperm motility, while sperm head abnormality increased in caffeine treated rats when compared to the control. However, AGLE significantly (p<0.05) protected the treated albino rat models from caffeine induced spermatotoxicity in a dose-dependent manner. These results show that AGLE is effective in protecting albino rat models against caffeine induced spermatotoxicity in a dose dependent manner.

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Section: Introductionmentioning

confidence: 99%

“…Consumption of caffeine has also been linked with delayed conception (Bolumar et al, 1997), reproductive and developmental toxicities (Ekaluo et al, 2013a(Ekaluo et al, , b, 2014 and increase in the frequency of sperm abnormalities (Robbins et al, 1997;Ekaluo et al, 2005Ekaluo et al, , 2009.…”

Section: Introductionmentioning

confidence: 99%

Attenuating Potential of Trévo Dietary Supplement on Caffeine Induced Sperm Toxicities in Albino Rats

Ekaluo¹,

Uno²,

Ekpo³

et al. 2015

Asian J. of Clinical Nutrition

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The attenuating potential of Trévo Dietary Supplement (TDS), a multi-herbal health drink containing 174 ingredients on caffeine-induced sperm toxicities was studied on albino rats. Thirty healthy male albino rats of 12 weeks old were divided into five groups with six rats in each group using a Completely Randomized Design (CRD). The experimental animals were treated with combinations of caffeine and TDS orally. The treatment lasted for 65 days. Results indicated statistically significant (p<0.05) decreases in weight of testes and epididymis, epididymal sperm viability, motility and count in caffeine treated rats. There was a concomitant increase in sperm head abnormalities in caffeine treated rats. However, TDS effectively attenuated the caffeine induced sperm toxicities in albino rat models in a dose dependent manner.

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Comparative Toxicity of Five Commonly Used Analgesics on Rat Sperm Count and Sperm Morphology

Cited by 11 publications

References 0 publications

Effect of Aqueous Extract of Tigernut (Cyperus esculentus L.) on Sperm Parameters and Testosterone Level of Male Albino Rats

Effect of Aqueous Extract of Tigernut (Cyperus esculentus L.) on Sperm Parameters and Testosterone Level of Male Albino Rats

Protective Role of Aqueous Guava Leaf Extract Against Caffeine Induced Spermatotoxicity in Albino Rats

Attenuating Potential of Trévo Dietary Supplement on Caffeine Induced Sperm Toxicities in Albino Rats

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