Comparative study of volumetric changes and trabecular microarchitecture in human maxillary sinus bone augmentation with bioactive glass and autogenous bone graft: a prospective and randomized assessment

Abstract

The aim of this study was to compare the volumetric changes and the new bone microarchitecture in human maxillary sinuses augmented with bioactive glass (Biogran) alone, bioactive glass combined with autogenous bone graft (1:1), or autogenous bone graft alone. Twelve maxillary sinuses were grafted with bioactive glass (group 1), nine with bioactive glass mixed with autogenous bone graft 1:1 (group 2), and 12 with autogenous bone graft (group 3). Patients underwent cone beam computed tomography 15days after the procedure to determine the initial volume of the graft (T1) and again 6 months later (T2). Biopsies were obtained at the time of dental implant placement and were subjected to micro-computed tomography. The volumetric change was 44.2% in group 1, 37.9% in group 2, and 45.7% in group 3 (P>0.05). The trabecular microarchitecture results showed that the materials used in groups 1 and 2 were good bone substitutes. However, the addition of 50% bioactive glass to autogenous bone graft improved the microarchitecture of the graft. Furthermore, the results for volumetric changes indicated that bioactive glass, its association with autogenous bone graft in a 1:1 ratio, and autogenous bone graft alone have similar resorption.

Maxillary Sinus Floor Augmentation with Autogenous Bone Graft Alone Compared with Alternate Grafting Materials: a Systematic Review and Meta-Analysis Focusing on Histomorphometric Outcome

“…Partially and totally edentulous patients with atrophy of the posterior maxilla were enrolled in the included studies. Power calculation was performed in three studies [42,44,45]. A split-mouth study design was used in seven studies [30,31,[33][34][35]40,41].…”

“…Residual bone height as well as inclusion and exclusion criteria were clearly specified in all included studies [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45]. Randomization was conducted using a randomization table [32,35,40], computer-generated randomization code [41], allocation concealment process [37], drawing lots [42][43][44][45], coin-toss method [34], or no information was provided about the randomization procedure [30,31,33,36,38,39]. The surgical procedure was performed by one surgeon [36,39,40,44] [31].…”

Bone Regeneration in Peri-Implant Defect Using Autogenous Tooth Biomaterial Enriched with Platelet-Rich Fibrin in Animal Model

“…Autogenous bone grafts have been used in combination with bioactive glass [11] and bovine bone grafts [12] to enhance the bone volume fraction. When autogenous bone graft is used in combination it offers certain advantages like increased volume of the graft and obviates the need for large amounts of autogenous bone [13].…”

Morphometric and chemical characterization of bone grafting particles used in guided bone regeneration

“…Conocer la relación Ca/P de las partículas óseas es trascendental en los procesos regenerativos, ya que relaciones óptimas permitirían una correcta adhesión de osteoblastos a las partículas (17,28,29). Se ha descrito que las partículas óseas xenogénicas injertadas en elevaciones de piso de seno maxilar poseen mayores concentraciones de Ca y una relación Ca/P mayor (1,9) que el tejido óseo regenerado alrededor de las partículas (1,4) (30). En el mismo sentido, estudios que han utilizado partículas de CaS para elevación de piso de seno, observaron mayores concentraciones de Ca y una relación Ca/P mayor (8,5) que la zona mineralizada que se produce alrededor de la partícula (1,63) (31).…”

“…Para superar estas desventajas, hoy disponemos de partículas alogénicas, que son partículas óseas que provienen de la misma especie, pero de diferente individuo, o las xenogénicas que se obtienen de diferentes especies; ambas son sometidas a un procesado especial para eliminar la capacidad antigénica y poseen una gran capacidad osteoconductora. Por último, se encuentran las partículas aloplásticas o injertos sintéticos, las cuales se obtienen a partir de procesos de síntesis química y están constituidas a base de hidroxiapatita, fosfato tricálcico ó vidrio bioactivo; su función, al igual que las anteriores, es poseer una importante capacidad osteoconductora (6)(7)(8)(9)(10).…”