Eur. J. Chem. volume 7, issue 3, P315-321 2016 DOI: 10.5155/eurjchem.7.3.315-321.1468
Adel Magdy Michael, Yasmin Mohamed Fayez, Christine Kamal Nessim, Hayam Mahmoud Lotfy

Accurate, rapid, and selective reversed phase HPLC and HPTLC-densitometric methods with UV detection have been developed and validated for simultaneous determination of a binary mixture of mebeverine hydrochloride (MVH) and chlordiazepoxide (CDZ) in their Coformulation. For the HPLC method, ACE-126-2546 AQ C-18 column, (250×4.6 mm i.d., 5 μm particle size) in isocratic mode, with mobile phase containing 25 mM ammonium acetate buffer: acetonitrile in the ratio of (60:40, v:v), pH adjusted to 3±0.2 by using …


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