2018
DOI: 10.3390/ijms20010005
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Abstract: It is widely accepted that different strains of Mycobacterium tuberculosis have variable degrees of pathogenicity and induce different immune responses in infected hosts. Similarly, different strains of Mycobacterium bovis have been identified but there is a lack of information regarding the degree of pathogenicity of these strains and their ability to provoke host immune responses. Therefore, in the current study, we used a mouse model to evaluate various factors involved in the severity of disease progressio… Show more

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Cited by 15 publications
(8 citation statements)
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References 62 publications
(72 reference statements)
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“…The M. bovis N strain was isolated recently from the brain tissue of cattle with generalized bovine tuberculosis. Both strains have been identified as M. bovis by the multilocus sequence typing analysis as described earlier [49] and the virulence of both strains have been reported recently [50]. The M. bovis N strain was isolated by our laboratory and cultured for few passages before infecting the cells while the M. bovis C68004 strain was obtained from cold storage and was passaged for three times after its re-isolation from experimentally infected animals.…”
Section: Methodsmentioning
confidence: 99%
“…The M. bovis N strain was isolated recently from the brain tissue of cattle with generalized bovine tuberculosis. Both strains have been identified as M. bovis by the multilocus sequence typing analysis as described earlier [49] and the virulence of both strains have been reported recently [50]. The M. bovis N strain was isolated by our laboratory and cultured for few passages before infecting the cells while the M. bovis C68004 strain was obtained from cold storage and was passaged for three times after its re-isolation from experimentally infected animals.…”
Section: Methodsmentioning
confidence: 99%
“…Though the different members of the MTBC have different tropisms, involving specific virulence profiles and metabolic changes made in response to the host environment, nearly 99% of the genomic sequence is conserved among the MTBC members (Malone and Gordon, 2017). The minor variations such as deletions and single nucleotide polymorphisms (SNPs) that vary among species members of the MTBC, and between species-specific strains, seem to have an outsized role determining these preferences (Dinan et al, 2014); (Malone et al, 2018); (Chiner-Oms et al, 2019); (Cheng et al, 2019). Therefore, it is logical to hypothesize that non-coding RNA (ncRNA) is involved at both the transcriptional and post-transcriptional level of gene regulation, magnifying small genetic changes and creating the documented level of phenotypic diversity (Schwenk & Arnvig, 2018).…”
Section: Why Pathogenic Mycobacteria and Why Non-coding Rna?mentioning
confidence: 99%
“…Among the techniques mentioned above for strain differentiation, WGS is best suited for virulence assessment. WGS enables the statistic association of newly reported SNPs, insertions and deletions that may explain certain virulence phenotypes, but also the calculation of indicators of selective pressure exerted on specific virulence genes (Abdelaal et al, 2019; Cheng et al, 2018; Hauer et al, 2019). Besides, virulence phenotype–genotype associations can also be inferred by transcriptomic profiling and differential expression analysis in different strains (Malone et al, 2018).…”
Section: Drivers Of Animal Tb Heterogeneitymentioning
confidence: 99%