Comparative study of the inhibitory effects of lotus seedpod oligomeric procyanidins on dietary AGE released from glycated casein during digestion

Wu, Qian; Ouyang, Yu; Feng, Yingna; Kong, Yingfei; Liang, Yinggang; Zhang, Chan; Xiao, Juan; Zhou, Mengzhou; He, Yi; Feng, Nianjie

doi:10.1016/j.foodres.2021.110912

Cited by 12 publications

(18 citation statements)

References 41 publications

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“…Before phytochemicals identification, the above-mentioned lotus seedpods extracts are usually purified by organic solvent ( n -BuOH or ethyl acetate) fractionation ( 8 , 35 , 39 – 44 ), column (silica gel column, AB-8 macroporous resin or S8 resin column) adsorption ( 14 , 35 , 39 , 40 , 42 – 47 ), and Sephadex LH-20 column chromatography ( 35 , 40 , 46 , 47 ). The lotus seedpods extracts before and after purification can be identified by electrospray ionization-mass spectrometry (ESI-MS) ( 34 , 35 , 46 ), nuclear magnetic resonance spectrometer (NMR) ( 34 , 35 , 47 , 48 ), high-performance liquid chromatography (HPLC)/electrospray ionization tandem mass spectrometry (ESI-MS-MS) ( 9 ), HPLC-diode array detector (DAD)-ESI-MS ( 8 ), HPLC-ESI-MS ( 14 , 49 ), LC-MS ( 38 , 44 ), HPLC-DAD ( 40 ), HPLC-DAD-MS ( 50 ), ultra-performance liquid chromatography triple-time of flight/MS (UPLC-TOF/MS) ( 45 , 51 ) and/or UPLC-quadrupole (Q) TOF-MS ( 41 ) methods. However, the analyses of phytochemicals might be limited by the capacity of the identification database, as above-mentioned detection methods depended deeply on standard secondary spectra database ( 41 ).…”

Section: Preparation and Identification Of Phytochemicals From Lotus ...mentioning

confidence: 99%

“…Among them, (+)-catechin had much better inhibition activity on AGE formation and methylglyoxal scavenging effect, while syringic acid showed the best scavenging ability on DPPH radical. Furthermore, Wu et al ( 49 ) have compared the inhibitory effects of oligomeric procyanidin from lotus seedpods and its three main monomers [(+)-catechin, (-)-epicatechin and (-)-epigallocatechin gallate] on releases of AGE and CML formation in simulated gastrointestinal digestion, for studying the structure-activity relationship. The results indicated that (-)-epigallocatechin gallate exhibited the strongest activities.…”

Section: Biological Activity Of Phytochemicals From Lotus Seedpodsmentioning

confidence: 99%

“…Lotus seedpod extracts ( 8 , 82 ), proanthocyanidin ( 83 , 84 ) and oligomeric procyanidin ( 5 , 19 , 23 , 43 , 44 , 49 , 72 , 85 , 86 ) can be used in food industry. Lotus seedpod extracts can inhibit lipid oxidation.…”

Section: Applications Of Raw Material Extracts and Phytochemicals Of ...mentioning

confidence: 99%

“…Meanwhile, addition of lotus seedpod oligomeric procyanidin increased the growth of Lactobacillus plantarum , titratable acidity, DPPH scavenging effect, solid-like properties, hardness, adhesiveness, gumminess and chewiness of yogurt ( 86 ). Moreover, lotus seedpod oligomeric procyanidin and its three monomers including catechin, epicatechin and epigallocatechin gallate could inhibit AGEs release from glycated casein during gastrointestinal digestion ( 49 ). At the same time, lotus seedpod oligomeric procyanidin and catechin could also enhance the scavenging effects of digestive fluid on DPPH, OH and ABTS radicals and its ferric reducing ability ( 19 ).…”

Section: Applications Of Raw Material Extracts and Phytochemicals Of ...mentioning

confidence: 99%

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Phytochemicals, biological activity, and industrial application of lotus seedpod (Receptaculum Nelumbinis): A review

Wang

Shen

et al. 2022

Front. Nutr.

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Lotus (Nelumbo nucifera Gaertn.) is a well-known food and medicinal plant. Lotus seedpod (Receptaculum Nelumbinis) is the by-products during lotus products processing, which is considered as waste. Numerous studies have been conducted on its phytochemicals, biological activity and industrial application. However, the information on lotus seedpod is scattered and has been rarely summarized. In this review, summaries on preparation and identification of phytochemicals, the biological activities of extracts and phytochemicals, and applications of raw material, extracts and phytochemicals for lotus seedpod were made. Meanwhile, the future study trend was proposed. Recent evidence indicated that lotus seedpods extracts, obtained by non-organic and organic solvents, possessed several activities, which were influenced by extraction solvents and methods. Lotus seedpods were rich in phytochemicals categorized as different chemical groups, such as proanthocyanidins, oligomeric procyanidins, flavonoids, alkaloids, terpenoids, etc. These phytochemicals exhibited various bioactivities, including ameliorating cognitive impairment, antioxidation, antibacterial, anti-glycative, neuroprotection, anti-tyrosinase and other activities. Raw material, extracts and phytochemicals of lotus seedpods could be utilized as sources for biochar and biomass material, in food industry and as dye. This review gives well-understanding on lotus seedpod, and provides theoretical basis for its future research and application.

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Section: Preparation and Identification Of Phytochemicals From Lotus ...mentioning

confidence: 99%

Section: Biological Activity Of Phytochemicals From Lotus Seedpodsmentioning

confidence: 99%

Section: Applications Of Raw Material Extracts and Phytochemicals Of ...mentioning

confidence: 99%

Section: Applications Of Raw Material Extracts and Phytochemicals Of ...mentioning

confidence: 99%

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Phytochemicals, biological activity, and industrial application of lotus seedpod (Receptaculum Nelumbinis): A review

Wang

Shen

et al. 2022

Front. Nutr.

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“…So far, the extract of lotus seedpod is the only part rich in proanthocyanidins [9]. Previous studies reported that proanthocyanidins possessed anti-tumor effects [10], potent antioxidant capacity [11,12], inhibited advanced glycation-end products formation [9], neuroprotective effects [13], restrained the inflammatory response [14], and attenuated age-related deficits in cognitive functions [15]. In the latest study, the extract of lotus seedpod was investigated to protect LPS-induced hepatotoxicity through inhibiting pro-inflammatory cytokines mediators expression [16], and reduced lipid accumulation and lipotoxicity in hepatocytes [17].…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Activity of Nelumbo nucifera Gaertn. Seedpod Extract Attenuated Acetaminophen-Induced Hepatotoxicity

et al. 2022

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The aim is to investigate the effect of lotus (Nelumbo nucifera Gaertn.) seedpod extract (LSE) on acetaminophen (APAP)-induced hepatotoxicity. LSE is rich in polyphenols and has potent antioxidant capacity. APAP is a commonly used analgesic, while APAP overdose is the main reason for drug toxicity in the liver. Until now, there has been no in vitro test of LSE in drug-induced hepatotoxicity responses. LSEs were used to evaluate the effect on APAP-induced cytotoxicity, ROS level, apoptotic rate, and molecule mechanisms. The co-treatment of APAP and LSEs elevated the survival rate and decreased intracellular ROS levels on HepG2 cells. LSEs treatment could significantly reduce APAP-induced HepG2 apoptosis assessed by DAPI and Annexin V/PI. The further molecule mechanisms indicated that LSEs decreased Fas/FasL binding and reduced Bax and tBid to restore mitochondrial structure and subsequently suppress downstream apoptosis cascade activation. These declines in COX-2, NF-κB, and iNOS levels were observed in co-treatment APAP and LSEs, which indicated that LSEs could ameliorate APAP-induced inflammation. LSE protected APAP-induced apoptosis by preventing extrinsic, intrinsic, and JNK-mediated pathways. In addition, the restoration of mitochondria and inflammatory suppression in LSEs treatments indicated that LSEs could decrease oxidative stress induced by toxic APAP. Therefore, LSE could be a novel therapeutic option for an antidote against overdose of APAP.

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Protective mechanism of fruit vinegar polyphenols against AGEs-induced Caco-2 cell damage

Kong

Liang

et al. 2023

Food Chemistry: X

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Comparative study of the inhibitory effects of lotus seedpod oligomeric procyanidins on dietary AGE released from glycated casein during digestion

Cited by 12 publications

References 41 publications

Phytochemicals, biological activity, and industrial application of lotus seedpod (Receptaculum Nelumbinis): A review

Phytochemicals, biological activity, and industrial application of lotus seedpod (Receptaculum Nelumbinis): A review

Hepatoprotective Activity of Nelumbo nucifera Gaertn. Seedpod Extract Attenuated Acetaminophen-Induced Hepatotoxicity

Protective mechanism of fruit vinegar polyphenols against AGEs-induced Caco-2 cell damage

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