Comparative Study of the Antiarrhythmic Activity of Liposomal Forms of Lappaconitine Hydrobromide and its Complex with Glycyrrhizic Acid Monoammonium Salt in the Aconitine Arrhythmia Model

Uzbekov, V. V.; Abdullaev, B. F.; Jumayev, I. Z.; Oshchepkova, Yu. I.; Usmanov, P. B.; Салихов, Ш. И.

doi:10.1007/s11094-023-02793-5

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…The works of Uzbekov et al proposed the encapsulation of a modified form of allapinin complexed with the monoammonium salt of glycyrrhizic acid (MASGA) [ 20 ]. The complex of this substance in a molar ratio of 1:4 with MASGA has a high solubility and more pronounced antiarrhythmic activity than simple allapinin and maintains the reduced contractile activity for a longer period [ 21 , 22 ]. In their study, the authors showed that when the encapsulated form of the allapinin–monoammonium salt of glycyrrhizic acid complex is released into the blood, the therapeutic dose is released over a longer period of time [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Polyelectrolyte Microcapsules: An Extended Release System for the Antiarrhythmic Complex of Allapinin with Glycyrrhizic Acid Salt

Salikhov,

Musin,

Kim

et al. 2024

IJMS

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Allapinin has antiarrhythmic activity and can be used to prevent and treat various supraventricular and ventricular arrhythmias. Nevertheless, it is highly toxic and has a number of side effects associated with non-specific accumulation in various tissues. The complex of this substance with the monoammonium salt of glycyrrhizic acid (Al:MASGA) has less toxicity and improved antiarrhythmic activity. However, the encapsulation of Al:MASGA in polyelectrolyte microcapsules (PMC) for prolonged release will reduce the residual adverse effects of this drug. In this work, the possibility of encapsulating the allapinin–MASGA complex in polyelectrolyte microcapsules based on polyallylamine and polystyrene sulfonate was investigated. The encapsulation methods of the allapinin–MASGA in polyelectrolyte microcapsules by adsorption and coprecipitation were compared. It was found that the coprecipitation method did not result in the encapsulation of Al:MASGA. The sorption method facilitated the encapsulation of up to 80% of the original substance content in solution in PMC. The release of the encapsulated substance was further investigated, and it was shown that the release of the encapsulated Al:MASGA was independent of the substance content in the capsules, but at pH 5, a two-fold decrease in the rate of drug release was observed.

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Section: Introductionmentioning

confidence: 99%

Polyelectrolyte Microcapsules: An Extended Release System for the Antiarrhythmic Complex of Allapinin with Glycyrrhizic Acid Salt

Salikhov,

Musin,

Kim

et al. 2024

IJMS

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The Protective Effect of Indole Alkaloid Vincanine Against Hypoxia-Induced Vasorelaxation Model of Rat Aorta

Mirzayeva,

Zaripov,

Zhumaev

et al. 2024

Biomed. Pharmacol. J.

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Introduction: Using conventional organ bath procedures, the current study sought to determine how vincanine hydrochloride affected vasorelaxation brought on by hypoxia in rat aortic rings. Methods: To induce hypoxia, we used a glucose-free Krebs solution that was infused with 95% N2 and 5% CO2. After 60 minutes of hypoxia, the effect of vincanine was evaluated on aortic rings that were precontracted with either 50 mM KCl or 1 µM phenylephrine (PE). The effect of vincanine was more noticeable in aortic rings that had been precontracted by PE as opposed to KCl. Additionally, when verapamil, a blocker of L-type VDCCs, was preincubated with endothelium-intact aortic rings and KCI was used for precontraction, the effect of vincanine on hypoxia-induced vasorelaxation was significantly reduced. Results: Vincanine inhibited hypoxia-induced vasorelaxation in aortic rings precontracted with PE in a calcium-free buffer. Furthermore, the presence of glibenclamide, a specific inhibitor of ATP-sensitive K+-channels (KATP), and tetraethylammonium chloride (TEA), a nonspecific inhibitor of calcium-activated large conductance K+-channels (BKca), significantly reduced the effect of vincanine on hypoxia-induced vasorelaxation. The removal of the endothelium also had a significant impact on the effect of vincanine on hypoxia-induced vasorelaxation. Conclusion: The present findings showed that alkaloid vincanine isolated from the leaves of Vinca minor H. significantly abolished the hypoxia-induced vasorelaxation in rat aorta. The obtained results suggest that vincanine may protect the rat aorta against hypoxic injuries in the vasculature.

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Comparative Study of the Antiarrhythmic Activity of Liposomal Forms of Lappaconitine Hydrobromide and its Complex with Glycyrrhizic Acid Monoammonium Salt in the Aconitine Arrhythmia Model

Cited by 2 publications

References 3 publications

Polyelectrolyte Microcapsules: An Extended Release System for the Antiarrhythmic Complex of Allapinin with Glycyrrhizic Acid Salt

Polyelectrolyte Microcapsules: An Extended Release System for the Antiarrhythmic Complex of Allapinin with Glycyrrhizic Acid Salt

The Protective Effect of Indole Alkaloid Vincanine Against Hypoxia-Induced Vasorelaxation Model of Rat Aorta

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