Comparative study of hypoglycemic and antibacterial activity of organic extracts of four Bangladeshi plants

Kabir, Mohammad Shah Hafez; Ahmad, Shabbir; Mahamoud, Md. Sofi; Chakrabarty, Nishan; Hoque, Md. Akramul; Hossain, Mohammed Kamal; Chy, Md. Nazim Uddin; Shoibe, Mohammed

doi:10.12980/jclm.4.2016j5-175

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…A well-known normoglycemic model was used to test the extract's hypoglycemic effect [11,15]. The animals in Group I (the normal control group) received saline, Group II (the positive control group) received Sitagliptin (100 mg/ 70 kg body weight) [16,17], and Groups III and IV received GGESE extracts in different strengths (400 mg/kg and 800 mg/kg, respectively).…”

Section: Anti-diabetic Effectmentioning

confidence: 99%

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"Exploration of Controlled Hypoglycemic Effect in Streptozotocin-Induced Type 1 Diabetes and Antibacterial Activity of Combination of Ethanolic Extract of Garlic (Allium Sativum) and Ginger (Zingiber Officinale) Stem; In Vivo Studies Supported by In Silico Study"

Ahmed

2023

BJSTR

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Ginger and Garlic have high pharmacological properties. Garlic and ginger stem extract (1:1) with absolute ethanol (GGESE) has been studied for their potential health benefits, including antidiabetic, antibacterial effects as well as their potentiality to aid in body weight reduction. Normal food along with GGESE extract was given to two groups of mice, and a weight variation test was performed. Along with normal foods, after 13 weeks of GGESE administration a moderately weight loss was observed in male mice group, and the difference was statistically significant. Two hours before blood collection, a single dose of 400, 800 mg/kg of the GGESE extract was given orally to control/experimental group of mice to determine the effects on blood glucose (BG) and oral glucose tolerance test (OGTT). Streptozotocin-induced type 1 diabetic mice, the test group, was treated at same dosage level to examine its antidiabetic effects in terms of BG control, body weight. The dose of 800 mg/kg showed the highest BG reduction that was from 19.7±0.51 mg/dl to 11.78±0.57 mg/dl in diabetic mice (𝑝 < 0.01). By identifying the zone of inhibition against different gram positive and gram-negative bacteria, antibacterial activity was evaluated at 1000, 800 and 600 μg/disc mg/ ml concentration of the extract. 1000 μg/disc showed highest zone of inhibition for S. aureus (18±0.97 mm), B. cereus (16±0.83 mm), S. typhi (15±0.81 mm), P. aeruginosa (16±0.59 mm). Furthermore, during our docking study, it was observed that ginger and garlic exhibited the highest fitness scores of -5.71 and -6.04, respectively, when interacting with the peroxisome proliferator-activated receptor gamma (PPARγ) enzyme, out of the ten major isolated compounds. The study evidenced scientifically the beneficial use of GGESE as an alternative medicine in management of diabetes and bacterial infection.

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Section: Anti-diabetic Effectmentioning

confidence: 99%

“…A blank disc coated with methanol, ethanol and distilled water was used as a negative control. 30 g of kanamycin in a disc was used as a positive control [15,16].…”

Section: In Vitro Antibacterial Activitymentioning

confidence: 99%

"Exploration of Controlled Hypoglycemic Effect in Streptozotocin-Induced Type 1 Diabetes and Antibacterial Activity of Combination of Ethanolic Extract of Garlic (Allium Sativum) and Ginger (Zingiber Officinale) Stem; In Vivo Studies Supported by In Silico Study"

Ahmed

2023

BJSTR

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“…The results showed that the minimum inhibitory concentrations ((MIC)) of crude ethanol extract and neutral metabolites were 25 mg/mL, 50 mg/mL and 100 mg/mL, respectively [ 89 ]. Mohammad Shah Hafez Kabir et al found that the maximum inhibitory range of methanol extract from C. recurvata to Bacillus cereus was 10.50 ± 0.5 mm [ 90 ]. Tianyan Yun et al found newly isolated extracts from medicinal plants ( Curculigo Capulata ) showed high antifungal activity against Foc TR4.…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Phytochemistry and Pharmacological Activity of Plants of Genus Curculigo: An Updated Review Since 2013

Wang

2021

Molecules

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The genus Curculigo, as a folk herbal medicine, has been used for many years in China, treating impotence, limb limpness, and arthritis of the lumbar and knee joints. The last systematic review of the genus Curculigo was written in 2013, scientifically categorizing the phytochemistry and biological activities. Hitherto, the original compounds and their pharmacological activities were presented as the development of this genus, but there is not an updated review. To conclude the progression of the genus Curculigo, we collected the new literature published from 2013 to 2021 in PubMed, Web of Science, Google Scholar databases, and the Chinese National Knowledge Infrastructure. The novel chlorophenolic glucosides, curculigine, phenolic glycosides, orcinosides and polysaccharides were isolated from Curculigo. The new analyzing methods were established to control the quality of Curculigo as a herbal medicine. In addition, the pharmacological effects of Curculigo focused on anti-diabetes, antibacterial, anti-inflammatory, osteoporosis, antioxidation, etc. The antitumor and neuroprotective activities were newly explored in recent years. The application of herbal medicine was gradually developed in scientific methods. The medicinal value of the genus Curculigo needs to further investigate its pharmacological mechanisms. This new review offers more insights into the exploitation of the pharmacological value of the genus Curculigo.

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“…The contemporary investigation addressed the presence of several isolated phytoconstituents such as Crassifoside A, Breviscaside A, Crassifogenin C, Crassifoside D, Curcapital, Isocurculigine [ 14 ]. In Addition, the current study proposed the hypoglycemic and anthelminthic activities proclaimed from roots [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative Assessment of Three Medicinal Plants against Diabetes and Oxidative Stress Using Experimental and Computational Approaches

Shah

Talukder

Uddin

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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The hilly and rural areas’ people of Bangladesh have a great history of putting into use numerous traditional medicinal plants to cure diseases. Therefore, with ethanol extract of Molineria capitulata (EEMC), methanol extract of Trichosanthes tricuspidata (METT), and methanol extract of Amorphophallus campanulatus (MEAC), we mandate evaluation of in vitro α-amylase inhibition, antioxidants, and molecular docking, and ADMET/T analysis. According to iodine starch methods, α-amylase inhibition was performed, and quantitative total phenolic and flavonoid content was determined by established methods, whereas DPPH free radical scavenging and reducing power assays were performed in previously established protocols, respectively. A comparative study among three plants (EEMC, METT, and MEAC) possessed a significant ( p < 0.01 ) effect but EEMC showed the highest impact on enzyme inhibition. Plants in the measuring phenolic content METT and flavonoid measurement MEAC displayed most potent in the same way in the DPPH test was METT, and in reducing power capability MEAC has showed the highest effect between three extracts. Docking’s study also reveals the compounds of METT (Cyclotricuspidoside A and Cyclotricuspidoside C) exhibit the superior score among all the compounds. This finding indicates that EEMC, METT, and MEAC substantially impact α-amylase inhibition along with antioxidants. In silico study also reveals the potency of these plants, but further in-depth, precise molecular studies are needed.

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Comparative study of hypoglycemic and antibacterial activity of organic extracts of four Bangladeshi plants

Cited by 4 publications

References 18 publications

"Exploration of Controlled Hypoglycemic Effect in Streptozotocin-Induced Type 1 Diabetes and Antibacterial Activity of Combination of Ethanolic Extract of Garlic (Allium Sativum) and Ginger (Zingiber Officinale) Stem; In Vivo Studies Supported by In Silico Study"

"Exploration of Controlled Hypoglycemic Effect in Streptozotocin-Induced Type 1 Diabetes and Antibacterial Activity of Combination of Ethanolic Extract of Garlic (Allium Sativum) and Ginger (Zingiber Officinale) Stem; In Vivo Studies Supported by In Silico Study"

Phytochemistry and Pharmacological Activity of Plants of Genus Curculigo: An Updated Review Since 2013

Comparative Assessment of Three Medicinal Plants against Diabetes and Oxidative Stress Using Experimental and Computational Approaches

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