Comparative Study of Antioxidant Activity of Ethanol and Aqueous Extracts of Different Parts of Nyctanthes Arbor-tristis Linn.

Patel, Saraswati; Gokhale, Mamta

doi:10.5530/pj.2016.2.3

Cited by 3 publications

(5 citation statements)

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“…Antioxidants play vital roles in the management of neurodegenerative disorders by rescuing the neurons from free radical-induced oxidative damage [13,24]. Free radicals are highly reactive species which cause oxidative damage to healthy cells, leading to disease conditions such as neoplasms, diabetes mellitus and AD [2].…”

Section: Discussionmentioning

confidence: 99%

Nootropic and neuroprotective effects of ethanol extract of <i>Vateria indica</i> L bark on scopolamine-induced cognitive deficit in mice

Alshabi¹,

Shaikh²,

Savant³

2020

Trop. J. Pharm Res

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Purpose: To investigate the neuroprotective and memory-boosting properties of ethanol extract of Vateria indica bark on scopolamine-mediated defects in learning and memory in young mice. Methods: The ethanol extract of V. indica bark was prepared via Soxhlet extraction and subjected to qualitative and quantitative phytochemical assessment. The acute toxicity of the extract was also evaluated in mice. Six groups of 3-month-old Swiss albino mice (6 per group) were used: normal control, negative control, piracetam group, 250 mg/kg V. indica extract alone group, 500 mg/kg V. indica extract alone group, 250 mg/kg V. indica extract + scopolamine group and 500 mg/kg V. indica extract + scopolamine group. The mice were pretreated with piracetam (standard nootropic drug) or varied doses of the extract for 14 days prior to induction of amnesia. With the exception of normal control group, amnesia induction using scopolamine (3 mg/kg) i.p. on day 14 at 1½ h after the last extract dose. Mice in normal and negative control groups received 0.5 % tragacanth orally at a dose of 10 mL/kg. Cognitive deficit was assessed using elevated plus maze (EPM), step-down avoidance, and Morris water maze (MWM) tests. Results: Qualitative phytochemical screening of V. indica bark extract showed flavonoids, phenolics, glycosides, tannins, carbohydrate, saponins and steroids. The total phenol and total flavonoid contents were 580.96 ± 0.95 mg GAE/g extract and 66.89 ± 0.56 mg RE/g extract, respectively. The mice tolerated the extract up to 5000 mg/kg bwt. They all survived during and after the acute toxicity study and no significant changes in appearance or general behavior were noticed. The extract significantly enhanced learning and memory, and improved spatial recognition in scopolamine-induced amnesic mice (p < 0.05). Acetylcholinesterase (AChE) activity and levels of dopamine and noradrenaline were markedly higher in negative control mice than in normal control, but were significantly reduced after pretreatment with ethanol extract of V. indica bark (p < 0.05). The results of histopathological examination provided evidence in support of the protective effect of the extract on hippocampal and cortical neurons. Conclusion: Pretreatment with ethanol extract of V. indica bark confers neuroprotection and enhances memory in young amnesic mice. Therefore, the extract of the plant can potentially be develpoed for the management of degenerative brain conditions. Keywords: Alzheimer’s disease, Cognitive deficit, Neuroprotection, Phytochemicals, Vateria indica

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Section: Discussionmentioning

confidence: 99%

Nootropic and neuroprotective effects of ethanol extract of <i>Vateria indica</i> L bark on scopolamine-induced cognitive deficit in mice

Alshabi¹,

Shaikh²,

Savant³

2020

Trop. J. Pharm Res

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“…Interestingly, betulinic acid was identified as an active antioxidant compound with an IC 50 of 18.03 µg/ml with the DPPH assay. This compound might interfere with the oxidation process by donating an electron to neutralize free radicals (Karan et al, 2019;Patel and Gokhale, 2016;Sousa et al, 2021). Other studies evaluated the antioxidant activities of different NAT flower extracts (ethanol, ethyl acetate, and water extracts) using DPPH radical scavenging, superoxide radical scavenging, lipid peroxidation, and reducing power assays.…”

Section: Antioxidant Effectmentioning

confidence: 99%

“…This finding indicated that although the extract showed a medium degree of antioxidant activity, its reducing power is weak. The difference in the antioxidant potency may be due to the solubility of antioxidant compounds in various solvents used in the extraction process (Mishra et al, 2016a;Patel and Gokhale, 2016).…”

Section: Antioxidant Effectmentioning

confidence: 99%

“…In vitro (Michael et al, 2013) Aqueous extract Antioxidant In vitro (Patel and Gokhale, 2016) Ethanol extract Antioxidant In vitro and in vivo (Chaudhary et al, 2018;Patel and Gokhale, 2016) Betulinic acid isolate Antioxidant In vitro (Karan et al, 2019) Ethanol extract Anti-Malassezia In vitro (Han et al, 2014;Mishra et al, 2016b) Ethanol extract A decrease in hyperglycemia and hyperlipid…”

Section: Leaf Methanol Extract Antioxidantmentioning

confidence: 99%

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A comprehensive review on the phytoconstituents and biological activities of Nyctanthes arbor-tristis L.

Dewi¹,

Fakhrudin²,

Wahyuono³

2022

j app pharm sci

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Nyctanthes arbor-tristis (NAT) is one of the Indonesian herbal medicines which belongs to the genus Nyctanthes and the Oleaceae family. Traditionally, NAT is used to reduce fever and pain and treat hemorrhoids, irregular menstruation, cough, and asthma. This review article aimed to examine the phytoconstituents and pharmacological activities of NAT from different plant parts. The literature search was conducted through PubMed and Google Scholar databases. Our literature study showed that NAT has various secondary metabolites, such as steroids, terpenes, flavonoids, phenol, iridoid glycosides, and alkaloids. These compounds are distributed in the leaves, seeds, flowers, and stem bark. Different chemical structures of secondary metabolites are present in each plant part, and each demonstrates distinct pharmacological activities. The most common activities found in the literature are antimicrobial, analgesic, antiinflammatory, antidiabetic, antioxidant, hepatoprotective, antitussive, and antimalarial activities. Although this plant offers a promising source for drug discovery, the pharmacological and phytochemical data are still limited. Further studies are needed to explore the potency of NAT as natural products benefiting human health.

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“…Antioxidants, are vital substances which possess the ability to protect the body from possible harms caused by the free radical induced oxidative stress which damage the cells in our bodies. 1 A balance between free radicals and antioxidants is necessary for proper physiological function. 2 If the free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues.…”

Section: Introductionmentioning

confidence: 99%

Free Radical Scavenging Capacity and Antibacterial Activity of Wild Cirsium creticum from Turkey

Sabudak¹,

Gülen²,

Orak³

et al. 2017

IJPER

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Background: In recent years, there is increasing interest the using of herbal extracts derived from plants in medicine and as a dietary supplements. Objective: We aimed the determination of the antioxidant and antibacterial activity of Cirsium creticum (Lam) d'Urv. subsp. creticum included Asteraceae family which is wild plant species in Trakya region. Methods: Crude n-hexane, diethyl ether, ethylacetate and methanol extracts from whole plants was used the determination of antiradical and antibacterial activity in C. creticum and compared in terms of extracts efficiency. Results: EC 50 values of DPPH activity in different solvents revealed significant differences similar to TPC content. The lowest inhibitory effect was found to be Gram negative for E. coli, despite the highest inhibitory effect against Gram positive S. aureus. Conclusion: Antiradical and antimicrobial activity results presented that C. creticum, could be evaluate in food supplements and pharmaceutical industry as natural compound, and future investigations will be aimed the isolations of biologically active compounds to define individual active components.

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Comparative Study of Antioxidant Activity of Ethanol and Aqueous Extracts of Different Parts of Nyctanthes Arbor-tristis Linn.

Cited by 3 publications

References 9 publications

Nootropic and neuroprotective effects of ethanol extract of <i>Vateria indica</i> L bark on scopolamine-induced cognitive deficit in mice

Nootropic and neuroprotective effects of ethanol extract of <i>Vateria indica</i> L bark on scopolamine-induced cognitive deficit in mice

A comprehensive review on the phytoconstituents and biological activities of Nyctanthes arbor-tristis L.

Free Radical Scavenging Capacity and Antibacterial Activity of Wild Cirsium creticum from Turkey

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