volume 270, issue 1-2, P75-82 2004
DOI: 10.1016/j.ijpharm.2003.10.035
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Abstract: The effect of the amoxicilline as a possible cisplatin-action protector on pBR322 DNA has been visually studied by atomic force microscopy in comparison with the modifications caused by the controversed cisplatin protector amifostine. Incubation of amoxicilline with the plasmid DNA showed aggregation and compaction of DNA. Cisplatin incubated in the same conditions with DNA produced kinks and super-coiling of the circular form. In the case of previous treatment of DNA with amoxicilline, the characteristic effe…

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