2019
DOI: 10.1111/acel.13009
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Abstract: The mitochondrial oxidative theory of aging has been repeatedly investigated over the past 30 years by comparing the efflux of hydrogen peroxide (H2O2) from isolated mitochondria of long‐ and short‐lived species using horseradish peroxidase‐based assays. However, a clear consensus regarding the relationship between H2O2 production rates and longevity has not emerged. Concomitantly, novel insights into the mechanisms of reactive oxygen species (ROS) handling by mitochondria themselves should have raised concern… Show more

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Cited by 28 publications
(24 citation statements)
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References 96 publications
(159 reference statements)
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“…Under these conditions, mitochondria and NOX are the major ROS producers ( Tarafdar and Pula, 2018 ; Barua et al, 2019 ). However, before its diffusion to the cytoplasm, the internal consumption of H 2 O 2 in mitochondria is much higher than originally anticipated ( Munro and Pamenter, 2019 ) and during oxidative stress, mitochondria may be victims rather than producers of oxidative damage ( Gandhi and Abramov, 2012 ). Indeed, in AD models, the effects of mitochondrial ROS were found to be much smaller compared with those of NOX-produced ROS ( Angelova and Abramov, 2018 ).…”
Section: The Cytoplasmic Antioxidant Systemmentioning
confidence: 99%
“…Conversely, naked mole-rats are largely non-responsive to hypercapnia and associated acidity-related pain responses are largely absent [49,50]. Naked mole-rats also have numerous adaptations that are not as obviously linked to their natural habitat, including a remarkable resistance to cancer [51,52], they are the only mammalian thermo-conformer and almost entirely ectothermic for regulation of body temperature [53,54] and they have remarkable longevity [55,56,57,58]. These traits make the naked mole-rat an important animal model for a range of human diseases and for furthering understanding of pathways underlying cancer resistance and longevity [59,60,61].…”
Section: Introductionmentioning
confidence: 99%
“…However, both the activity (Page et al 2010) and the amount (Brown and Stuart 2007) of the mitochondrial form of superoxide dismutase, MnSOD, positively correlated with mammalian longevity, similarly to what we report in the current study for mtBER. Other studies also point to an especially important role of mitochondrial compared to total cell tissue antioxidants concerning longevity (Schriner et al 2005;Munro and Baldy 2019;Munro and Pamenter 2019).…”
Section: Discussionmentioning
confidence: 99%
“…Ecologists and evolutionary biologists have long been intrigued by inter‐ and intraspecific variation in life‐history strategies and the trade‐offs that arise from the interactions among life‐history traits (Stearns, 1992; Zera & Harshman, 2001). Considerable effort has been spent attempting to elucidate the physiological mechanisms that underlie individual variation in life‐history traits such as physical performance (Irschick & Higham, 2016; Killen, Calsbeek, & Williams, 2017; Scott, Guo, & Dawson, 2018), longevity (Miller et al ., 2011; Munro & Pamenter, 2019), reproduction (Harshman & Zera, 2007; Williams, 2012 a ; Zhang & Hood, 2016), and growth and development (Mueller et al ., 2015). Recently, researchers have focused on bioenergetics and oxidative stress (Monaghan, Metcalfe, & Torres, 2009; Zhang & Hood, 2016; Munro & Pamenter, 2019), as well as hormonal regulation (e.g.…”
Section: Introductionmentioning
confidence: 99%
“…Considerable effort has been spent attempting to elucidate the physiological mechanisms that underlie individual variation in life‐history traits such as physical performance (Irschick & Higham, 2016; Killen, Calsbeek, & Williams, 2017; Scott, Guo, & Dawson, 2018), longevity (Miller et al ., 2011; Munro & Pamenter, 2019), reproduction (Harshman & Zera, 2007; Williams, 2012 a ; Zhang & Hood, 2016), and growth and development (Mueller et al ., 2015). Recently, researchers have focused on bioenergetics and oxidative stress (Monaghan, Metcalfe, & Torres, 2009; Zhang & Hood, 2016; Munro & Pamenter, 2019), as well as hormonal regulation (e.g. sex steroids, glucocorticoids) (Crespi et al ., 2013; Vera, Zenuto, & Antenucci, 2017; Eyck et al ., 2019), as potential physiological mechanisms mediating life‐history trade‐offs.…”
Section: Introductionmentioning
confidence: 99%