Comparative risks of non-prescription analgesics: a structured topic review and research priorities

Fries, James F.; Fürst, Daniel E.; Rothman, Kenneth J.; Stergachis, Andy; Vaida, Allen J.; Zelterman, Daniel; Reynolds, Kate M.; Green, Jody L.; Dart, Richard C.

doi:10.1517/14740338.2012.629782

Cited by 17 publications

(10 citation statements)

References 85 publications

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“…Pain and inflammatory conditions are very often the main direct or underlying reasons why people seek medical care, and such conditions become even more common with ageing . Unfortunately, although many of the currently available opioid and non‐opioid pharmacotherapeutic options, such as non‐steroidal anti‐inflammatory drugs (NSAIDs), acetaminophen (paracetamol) and others, are effective, they have use‐limiting adverse effects on gastrointestinal, kidney, liver or cardiovascular systems . Opioids have the additional problem of misuse and abuse potential .…”

Section: What Is Known and Objectivementioning

confidence: 99%

Curcumin in turmeric: Basic and clinical evidence for a potential role in analgesia

et al. 2018

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Pain and inflammatory conditions are very often the main direct or underlying reasons why people seek medical care, and such conditions become even more common with ageing. medicine might offer such alternatives, but the evidence must be based on pharmacologic properties and on clinical trial data. This review summarizes the evidence for one of these: the analgesic properties of turmeric and other curcumins. Methods:The PubMed database and other sources were searched using keywords related to turmeric, curcumin, antinociception and analgesia. Primary sources and reviews of preclinical and clinical studies were identified, assessed and summarized.Bibliographies within these sources provided additional information. Results:Turmeric has consistently been demonstrated to produce analgesic and antiinflammatory effects in animal models and in clinical trials, and appears to have less serious adverse effects than many current analgesics.What is new and conclusions: Turmeric (curcumin) appears to be a possible candidate for consideration for use as a stand-alone analgesic, or in analgesic combinations as part of opioid-, NSAID-or paracetamol (acetaminophen)-sparing strategies. K E Y W O R D Sanalgesia, anti-inflammatory, curcumin, non-opioid, traditional medicine, turmeric

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Section: What Is Known and Objectivementioning

confidence: 99%

Curcumin in turmeric: Basic and clinical evidence for a potential role in analgesia

et al. 2018

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“…More sophisticated research analyses are needed in this area to improve our understanding of dosing patterns of nonprescription analgesics. This requires improved patient education about nonprescription analgesic use and prevention of possible adverse events [38,39]. In OTC NSAID analgesic users, more caution is necessary in the elderly or in patients with rheumatoid arthritis who are already taking NSAIDs, or low dose aspirin, ACEI or diuretics.…”

Section: Prescription and Nonprescription Analgesics In Dental Usementioning

confidence: 99%

Analgesics Use in Dentistry

Krasniqi¹,

Daci²

2017

Pain Relief - From Analgesics to Alternative Therapies

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Pain is a protective warning sign activated by tissue damage during different pathological processes. The clinical manifestation of pain is individual, multifactorial and very complex and requires the implementation of sound pharmacological approaches. The treatment of odontogenic pain is focused not only in the relief of pain but also in the suppression of causes of pain, mainly the inflammation. Acting as inhibitors of pain mechanism, analgesics are used for symptomatic treatment of pain. There are several groups of analgesic drugs used in dentistry practice and most frequent are nonsteroidal anti-inflammatory drugs (NSAIDs) and aniline analgesics. The contemporary strategies for the treatment of odontogenic pain are focused in analgesic drug combinations, which are more effective and have a better safety profile. Ibuprofen and acetaminophen agents are considered gold standard of dental analgesia for mild to moderate intensity of pain, while in moderate to severe pain the use of individual opioid analgesics or combination of opioid and nonopioid analgesics is recommended. The treatment of pain in children and elderly patients is associated with some limitations accompanied with safety concerns and dose reduction. Treatment of pain in dentistry is focused in achieving the satisfactory level of analgesia at low doses possible.

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“…Analgesics are the focus of this study of OTC medicines because, worldwide OTC analgesics are the most consumed pharmaceutical medicines. On a weekly basis, 41 million people in the United States of America take aspirin, and 39 million take ibuprofen (Lavonas et al 2012). In Australia, analgesics are the second most commonly purchased OTC medication from pharmacies, after upper respiratory tract medicines (Bialy & Emmerton 2007), however, this excludes sales of 'off the shelf' analgesics widely available from other retail outlets.…”

Section: Otc Analgesic Usementioning

confidence: 99%

Over-the-counter analgesic use by urban Aboriginal people in South Australia

Cusack

Crespigny

Wilson³

2013

Health Soc Care Community

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Despite recent health gains for Australian Aboriginal people their significantly poorer health status compared with that of non-Aboriginal Australians remains significant. Within the context of high levels of mortality and morbidity, research highlights significant barriers to timely health-care, access and safe use of prescribed and over-the-counter medicines. The risks to Aboriginal people's health due to unsafe medication use are preventable. The purpose of this article is to present the findings from qualitative research focused on Aboriginal people's knowledge, use and experience of over-the-counter analgesics. The study was conducted in the north-western metropolitan area of Adelaide, which has the largest urban Aboriginal population in South Australia. The employment of an Aboriginal Elder as Cultural Advisor enabled engagement with Aboriginal participants. Purposive 'snow ball' sampling was used to recruit participants for four focus groups [n = 30] and one participant opting for a personal semi-structured interview. Participants worked with the researchers to develop the findings and formulate recommendations. The 25 women and 6 men, aged 20-80 years reported various chronic medical conditions. Focus groups/interview elicited accounts of critical issues concerning safe selection and use of over-the-counter analgesics. Serious health risks were evident due to limited knowledge about safe analgesic use and over-reliance on information from family, friends and advertising. Extremely poor access was reported by participants to culturally and linguistically appropriate information, education and advice from a range of doctors and other health professionals including Aboriginal health workers.

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Comparative risks of non-prescription analgesics: a structured topic review and research priorities

Abstract: Although generally safe, all non-prescription analgesics are associated with some harm, particularly when recommended dosing limits are exceeded. Research to quantify the competing risks of different analgesic strategies is urgently needed.

Cited by 17 publications

References 85 publications

Curcumin in turmeric: Basic and clinical evidence for a potential role in analgesia

Curcumin in turmeric: Basic and clinical evidence for a potential role in analgesia

Analgesics Use in Dentistry

Over-the-counter analgesic use by urban Aboriginal people in South Australia

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