Comparative review of imipenem/cilastatin versus meropenem

Salmon-Rousseau, Arnaud; Martins, Carlos Otávio Damas; Blot, Mathieu; Buisson, Marielle; Chavanet, P.; Piroth, Lionel

doi:10.1016/j.medmal.2020.01.001

Cited by 25 publications

(14 citation statements)

References 60 publications

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“…Cefepime and meropenem were the most effective agents, which were 100% effective against both Gram-positive and Gram-negative bacteria in our study. They are all used as firstline antimicrobials in human hospitals [46,47]. However, cefepime has proven to have adverse effects on the gastrointestinal tract of horses [48]; thus, the further evaluation of the pharmacokinetics of cefepime in donkeys prior to clinical administration is necessary.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Susceptibility of Bacterial Isolates from Donkey Uterine Infections, 2018–2021

Zhao¹,

Zhu²,

Liu³

et al. 2022

Veterinary Sciences

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Background: Endometritis is a common reproductive disease in equine animals. No investigation about the bacterial characteristics and antimicrobial susceptibility pattern of donkeys with endometritis has thus far been reported. Objectives: To determine the common uterine bacterial isolates from donkeys with endometritis and to evaluate their susceptibility to antimicrobials used for the treatment thereof. Study design: Retrospective case-series. Methods: Medical records at an equine clinical diagnostic center were retrospectively reviewed to identify submissions from donkeys with bacterial endometritis between 2018 and 2021. Data were extracted and analyzed descriptively in terms of the frequency of bacterial species, susceptibility to antimicrobials and multidrug resistance. Results: A total of 73 isolates were identified from 30 donkeys, of which 92% of the isolates were Gram-negative bacteria. Mixed cultures were found in 90% of the donkeys. The most common isolates were Escherichia coli (31.5%) and Acinetobacter spp. (21.9%). Susceptibility testing revealed that amikacin (98%), cefoxitin (95%), trimethoprim-sulfamethoxazole (78%) and gentamicin (74%) were the most efficient agents for donkeys. Multidrug resistance (MDR) was found in 20% of all bacterial isolates, of which all Pseudomonas aeruginosa isolates showed a multidrug resistance profile. Main limitations: The sample size was relatively small, which means a bias of selection may exist. The antimicrobial resistance and MDR of agents without break points were not calculated, which means the relative results may be underestimated in our study. Conclusions: Severe infections were detected in donkeys with endometritis. Antimicrobial resistance and MDR bacteria are not rare in our study. This study demonstrated that bacteria identification and antimicrobial susceptibility testing are highly recommended before the treatment of uterine infections in donkeys. Further studies, including the epidemiological investigation of bacterial endometritis of donkeys, should be conducted to provide a better understanding of this critical problem.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial Susceptibility of Bacterial Isolates from Donkey Uterine Infections, 2018–2021

Zhao¹,

Zhu²,

Liu³

et al. 2022

Veterinary Sciences

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“…Despite the negative results of the CSF bacteriological tests, severe clinical condition and staphylococcal bacteraemia, statistically associated with a 10% -30% risk of ME coexistence, necessitated the use of dual pharmacotherapy in this patient using both antiviral drugs and broad-spectrum antibiotics [16]. The treatment used was VAN -an antistaphylococcal glycopeptide antibiotic, MP -an antibiotic from the group of carbapenems, and CTX -characterized by excellent penetration through the inflamed blood-brain barrier [17,18,19]. Molecular virological diagnostics did not show the presence of genetic material of CMV and SARS-CoV-2 coronavirus in CSF.…”

Section: Discussionmentioning

confidence: 99%

Meningoencephalitis and postinflammatory hydrocephalus in the course of COVID-19 disease in newborn – the potential role of acetazolamide as add-on therapy to the standard treatment

Wątroba¹,

Bryda²

2022

Ann Agric Environ Med.

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“…To our knowledge, this was the first study to compare the carbapenems prescription pattern between the COVID-19 ICU and the GICU. Meropenem was the preferred agent used, as it had better activities on gram-negative bacteria and central nervous system penetration [ 30 ]. This is consistent with the observations in the recent systematic reviews [ 3 , 5 ].…”

Section: Discussionmentioning

confidence: 99%

Plethora of Antibiotics Usage and Evaluation of Carbapenem Prescribing Pattern in Intensive Care Units: A Single-Center Experience of Malaysian Academic Hospital

et al. 2022

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Excessive antibiotic consumption is still common among critically ill patients admitted to intensive care units (ICU), especially during the coronavirus disease 2019 (COVID-19) period. Moreover, information regarding antimicrobial consumption among ICUs in South-East Asia remains scarce and limited. This study aims to determine antibiotics utilization in ICUs by measuring antibiotics consumption over the past six years (2016–2021) and specifically evaluating carbapenems prescribed in a COVID-19 ICU and a general intensive care unit (GICU) during the second year of the COVID-19 pandemic. (2) Methods: This is a retrospective cross-sectional observational analysis of antibiotics consumption and carbapenems prescriptions. Antibiotic utilization data were estimated using the WHO Defined Daily Doses (DDD). Carbapenems prescription information was extracted from the audits conducted by ward pharmacists. Patients who were prescribed carbapenems during their admission to COVID-19 ICU and GICU were included. Patients who passed away before being reviewed by the pharmacists were excluded. (3) Results: In general, antibiotics consumption increased markedly in the year 2021 when compared to previous years. Majority of carbapenems were prescribed empirically (86.8%). Comparing COVID-19 ICU and GICU, the reasons for empirical carbapenems therapy in COVID-19 ICU was predominantly for therapy escalation (64.7% COVID-19 ICU vs. 34% GICU, p < 0.001), whereas empirical prescription in GICU was for coverage of extended-spectrum beta-lactamases (ESBL) gram-negative bacteria (GNB) (45.3% GICU vs. 22.4% COVID-19 ICU, p = 0.005). Despite microbiological evidence, the empirical carbapenems were continued for a median (interquartile range (IQR)) of seven (5–8) days. This implies the need for a rapid diagnostic assay on direct specimens, together with comprehensive antimicrobial stewardship (AMS) discourse with intensivists to address this issue.

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Comparative review of imipenem/cilastatin versus meropenem

Cited by 25 publications

References 60 publications

Antimicrobial Susceptibility of Bacterial Isolates from Donkey Uterine Infections, 2018–2021

Antimicrobial Susceptibility of Bacterial Isolates from Donkey Uterine Infections, 2018–2021

Meningoencephalitis and postinflammatory hydrocephalus in the course of COVID-19 disease in newborn – the potential role of acetazolamide as add-on therapy to the standard treatment

Plethora of Antibiotics Usage and Evaluation of Carbapenem Prescribing Pattern in Intensive Care Units: A Single-Center Experience of Malaysian Academic Hospital

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