Comparative Resuscitative Methods for Venlafaxine Toxicity in a Swine Model

Fulton, Lawrence V.; Aitken, Jason; Avery, J. L.; Kahl, Brooke; Negron, Abisai; Chavez, Barbara; Iosett, Nicole; Johnson, Don; O'Sullivan, Joseph

doi:10.7205/milmed-d-15-00241

Cited by 3 publications

(2 citation statements)

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“…A literature review reported an acute toxic dose of 1,500 to 7,500 mg (10 mg/kg in humans). 10 Other studies 19 used intravenous injections of acute toxic doses of 40 to 50 mg/kg in pigs. This dose is similar to the LD 50 of female rats (350 mg/ kg).…”

Section: Discussionmentioning

confidence: 99%

“…18 However, only a small number of controlled studies have detailed poisoning with this drug. 19 Although VEN exerts wellknown toxic effects on the nervous and cardiovascular systems, the potential toxic effects of this drug on other major organ systems must be investigated. Therefore, the aim of this study is to investigate acute and subchronic toxicity of VEN in liver, kidney, and gastric tissues.…”

Section: Introductionmentioning

confidence: 99%

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Toxicological Assessment of Venlafaxine: Acute and Subchronic Toxicity Study in Rats

et al. 2018

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Antidepressants are the most commonly prescribed drugs for psychiatric treatment, and venlafaxine (VEN) is one of the most popular options. Venlafaxine is a nontricyclic dual-acting serotonin-norepinephrine reuptake inhibitor. Although an increased incidence of acute toxicity and addiction has been reported, controlled studies examining its toxic effects on different organs are still lacking. This study investigated the possible toxic effects of VEN on the liver, kidney, and gastric tissues. Three groups of rats were administered saline, a single LD dose (350 mg/kg), or 100 mg/kg VEN daily, followed by increases in the dose of 50 mg/kg every 10 days for 30 days (about 10 times the therapeutic doses). The following parameters of liver and kidney injury were then assayed: alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transferase, prothrombin time, partial thromboplastin time, blood urea nitrogen, and serum creatinine. A histopathological examination was then conducted. Both acute and subchronic administration of VEN produced multiple clinical manifestations in the experimental animals, including seizures, coma, and even death. Moreover, the liver and renal function tests indicated injury in these tissues. Furthermore, the histopathological examination showed signs of organ toxicity after both acute and chronic VEN exposure. This study has shown that VEN has harmful effects on the liver, kidney, and stomach in either a single high dose (LD) or repeated exposure to 10 times the therapeutic doses. As a result, strategies to increase awareness of these effects among physicians and the public are needed because this drug may be addictive.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%