Comparative pharmacokinetics of oxytetracycline in tilapia (Oreochromis spp.) maintained at three different salinities

Sidhu, Pritam K.; Smith, Stephen A.; Mayer, Corinne; Magnin, Géraldine; Kuhn, David D.; Jaberi-Douraki, Majid; Coetzee, Johann F.

doi:10.1016/j.aquaculture.2018.06.044

Cited by 26 publications

(29 citation statements)

References 30 publications

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“…) and tilapia (Sidhu et al . ). Rigos and Smith () recently reviewed the pharmacokinetics of OTC in fish.…”

Section: Use Of Oxytetracycline In Farmed Fishmentioning

confidence: 97%

“…Indeed, a recent study performed with tilapia demonstrates that an oral dose of 50 mg kg −1 of OTC can be sufficient to treat the infectious diseases caused by sensitive pathogens with MIC ranging between 0.5 and 1.0 μg mL −1 in freshwater and brackish water (15 ppt), but a higher dose is necessary in saltwater (30 ppt) (Sidhu et al . ). OTC is poor to moderately absorbed through the intestinal tract of fish, but its absorption is rapid (EMA ; Romero et al .…”

Section: Use Of Oxytetracycline In Farmed Fishmentioning

confidence: 97%

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Oxytetracycline in intensive aquaculture: water quality during and after its administration, environmental fate, toxicity and bacterial resistance

Leal

Santos

Esteves

2018

Reviews in Aquaculture

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Oxytetracycline (OTC) is one of the most used antibiotics in aquaculture. This raises concerns due to its effects in human and animal health, the environmental contamination and the consequences arising therefrom. This review focuses on the OTC application in intensive aquaculture. It compiles and complements the dispersed information, presenting a comprehensive study about the OTC effects, from its administration to farmed fish, until its release into the surrounding aquatic systems. Several topics about OTC are presented and discussed: physicalchemical properties, interaction with ions, application to farmed fish, effects in water quality and possible treatments, biological activity and toxicity of OTC byproducts, environmental fate. Based on the information gathered, one concludes that OTC establishes strong complexes with Ca 2+ and Mg 2+ , which may have implications on its biological activity. OTC acts as inhibitor of protein synthesis and is poorly metabolized or unmetabolized by fish. Its common recommended daily dose is about 75 mg kg À1 but depends on the administration conditions and on target fish species. Regarding OTC removal from water within a semiclosed aquaculture's water circuit, ozonation and photodegradation are not completely efficient methods as none of them promotes total mineralization. However, photodegradation can be applied as a complementary method prior to ozonation, allowing to reduce costs. OTC by-products do not appear to retain its biological activity, but toxicity studies mimicking environmental conditions were not found. In open circuits (cages), water column where OTC is administered not suffer a specific treatment and the antibiotic is easily spread by the surrounding environments, affecting their inhabitants. OTC is released in the aquatic system in freely dissolved form and/or associated with organic or inorganic compounds, being subjected to natural photolysis, hydrolysis and/or biodegradation.

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“…) and tilapia (Sidhu et al . ). Rigos and Smith () recently reviewed the pharmacokinetics of OTC in fish.…”

Section: Use Of Oxytetracycline In Farmed Fishmentioning

confidence: 97%

Section: Use Of Oxytetracycline In Farmed Fishmentioning

confidence: 97%

Oxytetracycline in intensive aquaculture: water quality during and after its administration, environmental fate, toxicity and bacterial resistance

Leal

Santos

Esteves

2018

Reviews in Aquaculture

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“…Prior to intravenous and oral administration, fish were sedated with bicarbonate‐buffered (1:1) tricaine methanesulfonate (150 µg/L, MS‐222; Sidhu et al, 2018).…”

Section: Methodsmentioning

confidence: 99%

Pharmacokinetics, bioavailability, and tissue disposal profiles of Tiamulin fumarate in Nile tilapia (Oreochromis niloticus) following oral and intravenous administrations

Liu

Cao

Song

et al. 2021

Vet Pharm & Therapeutics

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Tiamulin fumarate (TIF) is a pleuromutilin antibiotic and has high activity against animal bacterial pathogens including aquatic bacterial pathogens. However, its pharmacokinetic profiles, tissue distribution characteristics and bioavailability in aquatic animals remain unknown. The objective of this study was to investigate the pharmacokinetics and tissue distribution regularities of TIF in tilapia (Oreochromis niloticus) following a single oral (PO) dose of 20 mg/kg body weight (bw) and a single intravenous (IV) dose of 5 mg/kg bw at 22 ± 1°C, respectively. TIF concentrations in tilapia plasma and tissues were determined using the isotope dilution HPLC‐HESI‐MS/MS procedure, which was validated according to the guidelines defined by US Food and Drug Administration. TIF was well distributed throughout the body compartments of tilapia judged by the apparent volume of distribution (Vd) >1 L/kg (6.69 L/kg PO and 1.78 L/kg IV). TIF had a short mean residence time (MRT; 22.82 h PO and 14.61 h IV) and quick total body clearance (CLb) (0.62 L kg−1 h−1 PO and 0.60 L kg−1 h−1 IV). The total area under the curve (AUCtot) of plasma were 32.25 μg h−1 ml−1 (PO) and 8.30 μg h−1 ml (IV), respectively, and the oral absolute bioavailability (F%) of TIF was calculated to be approximately 97.1%. For tissue distribution, high concentrations of TIF were found in kidney, and the longest MRT was recorded in bile. The withdrawal time (WT) of TIF in muscle, skin, liver, kidney, gill, and bile was 3.75 (4) and 1.79 (2), 1.77 (2) and 2.06 (3), 6.41 (7) and 1.97 (2), 6.95 (7) and 3.98 (4), 4.92 (5) and 2.36 (3), and 7.06 (8) and 6.16 (7) days after PO and IV administration, respectively. The present investigations indicated that TIF was quickly absorbed, well distributed, rapidly eliminated in tilapia, and it could serve as reference data for establishing use regimen and provide useful information for the further development of TIF in aquaculture.

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“…Then, the blood samples were centrifuged at 4,000 r/min for 5 min at 4 • C, and the supernatant plasma was transferred into a new tube. After collecting blood samples, the fish were immediately euthanized by immersion in an overdose of bicarbonate-buffered (1:1) tricaine methanesulfonate (250 mg/L, MS-222) (20) and then the tissues of muscle plus skin, liver, kidney, and gill were also collected from fish. The tissues were homogenized using a homogenizer and separately kept in sealed plastic bags.…”

Section: Oral Administration and Samplingmentioning

confidence: 99%

“…However, as far as we know, no information on residue depletion regularities of tiamulin in fish was reported. Moreover, in aquatic animals, the residue depletion and WT of a drug can be deeply affected by environmental factors, such as temperature, pH, and salinity (oxytetracycline in tilapia) of water in which the animals are raised (20,21). As far as temperature is concerned, because fish are heterothermic animals, a large number of researches showed that the absorption, distribution, biotransformation, and excretion of different drugs in different fish can be seriously affected by temperature, such as florfenicol in Nile tilapia (22,23), doxycycline in grass carp (24), florfenicol amine in crucian carp (25), and enrofloxacin and its metabolite ciprofloxacin in turbot (26).…”

Section: Introductionmentioning

confidence: 99%

Temperature-Dependent Residue Depletion Regularities of Tiamulin in Nile Tilapia (Oreochromis niloticus) Following Multiple Oral Administrations

et al. 2021

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The aim of this study was to investigate the effect of different water temperatures (19, 25, and 30°C) on tissue residue depletion of tiamulin in Nile tilapia (Oreochromis niloticus) after five consecutive days of oral administration at the dose of 20 mg/kg body weight and to calculate the corresponding elimination half-life (T1/2) and withdrawal times (WTs). After oral administration at scheduled 11 time points (1, 2, 3, 5, 7, 9, 12, 15, 20, 25, and 30 days), samples of plasma and tissues (muscle plus skin, liver, kidney, and gill) were collected. Tiamulin concentration in samples were determined by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). T1/2 was calculated by the equation: T1/2 = ln2/k. WT 1.4 software was used to calculate WT. The results showed that tiamulin was widely distributed in all tissue samples with the highest concentration in liver. At three different water temperatures, the T1/2 were calculated as 2.76, 2.13, and 1.64 days in plasma, 2.71, 1.85, and 1.31 days in muscle plus skin, 2.27, 1.70, and 1.50 days in liver, 2.84, 2.32, and 1.94 day in kidney, and 3.16, 2.42, and 1.74 days in gill, respectively. At 19°C, the order of WT is kidney (11.88 days) > liver (10.41 days) > gill (10.77 days) > plasma (8.83 days) > muscle plus skin (7.14 days). The WT for tiamulin at 25°C was in the following order: kidney (8.40 days) > liver (8.21 days) > gill (8.07 days) > plasma (7.24 days) > muscle plus skin (4.05 days). At 30°C, the WT dropped and shown as follows: gill (6.99 days) > kidney (6.51 days) > liver (6.29 days) > plasma (3.27 days) > muscle plus skin (2.92 days). The present investigations indicated that increasing the temperature from 19 to 30°C shortened T1/2 and WT of tiamulin in tilapia. To ensure the safety of fish consumption, the longest WT of tissues is suggested for tiamulin in Nile tilapia at the corresponding water temperature; i.e., WTs were 12 days at 19°C, 9 days at 25°C, and 7 days at 30°C, respectively. Overall, we intended to provide a theoretical basis for tissue residue depletion kinetics of tiamulin in fish and improve our understanding of the influence of the temperature on tissue residue depletion kinetics of tiamulin in fish.

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Comparative pharmacokinetics of oxytetracycline in tilapia (Oreochromis spp.) maintained at three different salinities

Cited by 26 publications

References 30 publications

Oxytetracycline in intensive aquaculture: water quality during and after its administration, environmental fate, toxicity and bacterial resistance

Oxytetracycline in intensive aquaculture: water quality during and after its administration, environmental fate, toxicity and bacterial resistance

Pharmacokinetics, bioavailability, and tissue disposal profiles of Tiamulin fumarate in Nile tilapia (Oreochromis niloticus) following oral and intravenous administrations

Temperature-Dependent Residue Depletion Regularities of Tiamulin in Nile Tilapia (Oreochromis niloticus) Following Multiple Oral Administrations

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