Comparative pharmacognostical and phytochemical study on Bergenia ligulata Wall. and Ammania buccifera Linn

Abstract

“Pashanbheda” is a controversial plant. Pharmacopeia considers Bergenia ligulata as official source of Pashanbheda and official substitute is Avera lanta. Review of the literature reveals that 23 different plants are reported in name of “Pashanbheda”. Ammania buccifera is an adulterant, which is used in Kerala under the name of Pashanbheda, found in moist places of India. The present study was undertaken to compare the roots of both the plants and to have a brief view point on similarities and dissimilarities between the plants. The pharmacognostical evaluation reveals that the rosette crystals of B. ligulata are bigger in size compared to that of A. buccifera and cork is present in B. ligulata, whereas it is absent in A. buccifera. HPTLC shows similar Rf values of both the drug, The quantitative estimation showed that total phenol content of both the drug was almost equal.

Bergenin from Bergenia Species Produces a Protective Response against Myocardial Infarction in Rats

“…However, some endogenous antioxidants, such as glutathione peroxidase (GPX), superoxide dismutase (SOD), and catalase (CAT), provide a first-line defense against the free radicals [44,45]. Previous studies reported that bergenin and the plant sources Bergenia ciliate, Bergenia ligulata Wall, and Ficus racemose L. significantly restore the SOD, GPX, and CAT enzymes' activities [46][47][48]. It is also reported that bergenin exhibits a significant activity against free radicals [13].…”

Biological and Pharmacological Activity of Plant Natural Compounds II

“…Furthermore, there was a near to normal restoration of the altered activity of carbohydrate metabolic enzymes as well as hepatic and kidney markers. Citronellol supplement preserved the histology of hepatic cells and pancreatic β-cells in streptozotocin-treated rats [124].…”

“…Citronellol (3,7-dimethyl-6-octen-1-ol) is a linear monoterpene alcohol naturally found in about 70 essential oils, with abundance in Cymbopogon nardus (L.) and citrus oil [124,125]. Cymbopogon nardus was previously used in Chinese medicine to treat rheumatism, fever, and digestive problems [126].…”

“…The constituents have been categorized into polyphenols, flavonoids, quinones, sterols, terpenes, tannins, lactones, and others [16,26,[64][65][66][67]. The major bioactive compounds are bergenin ( 1), (+)-catechin (2), gallic acid (3), β-sitosterol (4), catechin-7-O-β-d-glucoside ( 5), (+)-afzelechin (6), arbutin (10),4-O-galloylbergenin (12), 11-O-galloylbergenin (13), caffeoylquinic acid (21), pashaanolactone (26), 3,11-di-O-galloylbergenin (64), bergapten (66), kaempferol-3-O-rutinoside (70), quercetin-3-O-rutinoside ( 79), (+)-catechin-3-O-gallate (83), 2-O-caffeoylarbutin (86), leucocyanidin (124), methyl gallate (gallicin) (125), sitoinoside I ( 126), β-sitosterol-d-glucoside (127), avicularin (128), reynoutrin (129), procyanidin B1 (135), afzelin (140), and aloe-emodin (146).…”

Clinical Potential of Himalayan Herb Bergenia ligulata: An Evidence-Based Study

“…The plant has been used as a folk medicine since ancient times for dissolving kidney stones and is referred to as “ Paashanbheda” (Sanskrit: Paashan meaning “rockstone” and bheda meaning “piercing”) in the Indian traditional system of medicine— Ayurveda [ 7 ]. It has simple leaves of orbicular to obovate shape, stout root stock, and solid barrel-shaped cylindrical rhizome (1.5–3 cm in length and 1–2 cm in diameter) [ 8 ]. Himalayan communities consume the roots and rhizomes of the plant to treat wounds, septic, cough and cold, cardiac diseases, asthma, inflammation, gastrointestinal disorders, and different kinds of urinary problems [ 9 ].…”