Comparative Network Pharmacology Analysis of Classical TCM Prescriptions for Chronic Liver Disease

Chen, Zikun; Wang, Xiaoning; Li, Yuanyuan; Wang, Yahang; Tang, Kailin; Wu, Dingfeng; Zhao, Wenyan; Ma, Yueming; Liu, Ping; Cao, Zhiwei

doi:10.3389/fphar.2019.01353

Cited by 30 publications

(19 citation statements)

References 45 publications

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“…This means that most real-world clinical prescriptions would tend to have a high degree of herbal combinations as good as those of TEFD prescriptions. It is practical and reasonable that, in TCM clinical settings, most practitioners would directly adopt the classical prescriptions or use the classical prescriptions as a basic therapeutic framework for clinical treatments ( Duan et al, 2018 ; Chen et al, 2019 ).…”

Section: Resultsmentioning

confidence: 99%

Network Patterns of Herbal Combinations in Traditional Chinese Clinical Prescriptions

Wang

Peng

et al. 2021

Front. Pharmacol.

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As a well-established multidrug combinations schema, traditional Chinese medicine (herbal prescription) has been used for thousands of years in real-world clinical settings. This paper uses a complex network approach to investigate the regularities underlying multidrug combinations in herbal prescriptions. Using five collected large-scale real-world clinical herbal prescription datasets, we construct five weighted herbal combination networks with herb as nodes and herbal combinational use in herbal prescription as links. We found that the weight distribution of herbal combinations displays a clear power law, which means that most herb pairs were used in low frequency and some herb pairs were used in very high frequency. Furthermore, we found that it displays a clear linear negative correlation between the clustering coefficients and the degree of nodes in the herbal combination network (HCNet). This indicates that hierarchical properties exist in the HCNet. Finally, we investigate the molecular network interaction patterns between herb related target modules (i.e., subnetworks) in herbal prescriptions using a network-based approach and further explore the correlation between the distribution of herb combinations and prescriptions. We found that the more the hierarchical prescription, the better the corresponding effect. The results also reflected a well-recognized principle called “Jun-Chen-Zuo-Shi” in TCM formula theories. This also gives references for multidrug combination development in the field of network pharmacology and provides the guideline for the clinical use of combination therapy for chronic diseases.

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Section: Resultsmentioning

confidence: 99%

Network Patterns of Herbal Combinations in Traditional Chinese Clinical Prescriptions

Wang

Peng

et al. 2021

Front. Pharmacol.

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“…Currently, integrated network pharmacology and metabolomics have been widely used to investigate the mechanism of action of TCMs, such as the antidepressant mechanisms of Xiaoyaosan ( Liu et al, 2021 ) and detoxification mechanisms of Yunnanbaiyao ( Ren et al, 2020 ). Several successful metabolomics or network pharmacology tests on the anti-liver fibrosis mechanism of TCMs have been reported ( Chen et al, 2019 ; Xiong et al, 2020 ; Zhang et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Anti-Liver Fibrosis Activity and the Potential Mode of Action of Ruangan Granules: Integrated Network Pharmacology and Metabolomics

et al. 2022

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Ruangan granules (RGGs) have been used to treat liver fibrosis with good clinical efficacy for many years. However, the potential mechanism of action of RGGs against liver fibrosis is still unclear. In this study, we evaluated the quality and safety of this preparation and aimed to explore the anti-liver fibrosis activity and potential mode of action of RGGs using network pharmacology and metabolomics. The results showed that RGGs contained abundant ferulic acid, salvianolic acid B and paeoniflorin, and at the given contents and doses, RGGs were safe and presented anti-liver fibrosis activity. They presented anti-liver fibrosis activity by improving liver function (ALT and AST, p < 0.01) and pathology and decreasing fibrosis markers in the serum of rats caused by CCl4, including HA, LN, PC III, HYP, CoII-V, and α-SMA, and the oxidant stress and inflammatory response were also alleviated in a dose-dependent manner, especially for high-dose RGGs (p < 0.01). Further studies showed that RGGs inhibited the activation of the PI3K-Akt signaling pathway in rats induced by CCl4, regulated pyrimidine metabolism, improved oxidative stress and the inflammatory response by regulating mitochondrial morphology, and alleviated liver fibrosis. Luteolin, quercetin, morin and kaempferol were active compounds and presented the cytotoxicity toward to LX-02 cells. This study provides an overall view of the mechanism underlying the action of RGGs protecting against liver fibrosis.

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“…Network pharmacological studies have shown that YCHD can treat chronic liver diseases through functional modules such as immune response, inflammation, energy metabolism, and so on. However, compared with Huangqi decoction for qi deficiency syndrome, YCHD has unique functional modules related leptin-induced complement pathway and leukocyte migration across the endothelium, which may correlate with the anti-inflammatory effects [27].…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Clinical and Medication Information between Chronic Hepatitis B Patients with Damp Heat Syndrome and Spleen Deficiency Syndrome

Liu

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Traditional Chinese medicine (TCM) has a long history in the treatment of chronic hepatitis B (CHB) based on the syndrome identification. Previous studies reported CHB patients with damp-heat (DH) syndrome accompanied with a severe liver function damage, but lacked the medication analysis. In this study, we analyzed 999 CHB patients with unidentified individual-level data from database to explore clinical features of two common syndromes of CHB patients based on the real world. Compared with the spleen deficiency (SD) syndrome, the CHB patients with DH syndrome had a significantly higher level of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ( P < 0.05 ) but took more immunomodulators and hepatoprotective drugs ( P < 0.1 ). Similarly, in the follow-up of 207 patients after 3 months, the improvement trend of ALT and AST of patients with sustained SD syndrome was significantly better than those whose TCM syndrome changed from SD to DH ( P < 0.05 ). The logistic model indicated DH syndrome was a significant negative factor for reducing ALT level in CHB patients (OR = 4.854, P = 0.032 ). This study suggests that CHB patients with DH syndrome have potentially more serious and sustained liver damage than the SD syndrome, which provides a reference for the personalized management of CHB patients from the perspective of TCM syndromes.

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Comparative Network Pharmacology Analysis of Classical TCM Prescriptions for Chronic Liver Disease

Cited by 30 publications

References 45 publications

Network Patterns of Herbal Combinations in Traditional Chinese Clinical Prescriptions

Network Patterns of Herbal Combinations in Traditional Chinese Clinical Prescriptions

Anti-Liver Fibrosis Activity and the Potential Mode of Action of Ruangan Granules: Integrated Network Pharmacology and Metabolomics

Comparative Analysis of Clinical and Medication Information between Chronic Hepatitis B Patients with Damp Heat Syndrome and Spleen Deficiency Syndrome

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