Comparative Incidence of Inflammatory Bowel Disease in Different Age Groups in the United States

Abstract

<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Data on the incidence of inflammatory bowel disease (IBD) by age group are available in countries outside of the United States or localized populations within the United States. We aimed to estimate the incidence rates (IRs) of IBD by age group using a US multiregional data set.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>We used the Optum Research Database to identify incident IBD patients with a disease-free interval of 1.5 years between 2005 and 2015. Overall and age-specific IRs were calculated for 4 different age groups: pediatric (0–17 years), young adult (18–25 years), adult (26–59 years), elderly (&amp;gt;60 years). Time trends of incidence were evaluated in each age group. Perianal phenotype (in Crohn’s disease [CD]) was also compared.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>The mean IR for the cohort (n = 60,247) from 2005 to 2015 was 37.5/100,000. The IR was highest in adult and elderly cohorts (36.4 and 36.7/100,000 respectively). In the adult and elderly groups, the IR for UC was higher than that for CD, whereas the opposite was true in the pediatric and young adult groups. The IR increased over the 10-year study period for all age groups (time trends P &amp;lt; 0.001). The elderly group had less perianal disease than the adult group (20.8 vs 22.3%, respectively; P &amp;lt; 0.05).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>In one of the most comprehensive evaluations of the incidence of IBD in the United States, we found an incidence rate similar to those of other national populations. We also confirmed differences of specific IBD phenotypes based on age groups, with lower rates of perianal disease in the elderly.</jats:p> </jats:sec>

Incidence Trends of Inflammatory Bowel Disease in a Southern European Country: A Mirror of the Western World?

“…First, the low incidence values in young children over time do not resemble those of recent studies, including a meta-analysis that reported an increasing trend of IBD incidence in this age category in the Western world (24,25). On the other hand, incidence reports from the United Kingdom and the United States presented similar age distributions as those observed in this study (26,27). These results might suggest that IBD onset occurs more often after childhood among the Portuguese population.…”

The extracellular vesicle of gut microbial Paenalcaligenes hominis is a risk factor for vagus nerve-mediated cognitive impairment

“…Dysregulation of MGB axis by endogenous and exogenous factors, such as aging and social defeat, accelerates the occurrence of psychiatric disorders such as depression, anxiety, autism, and AD [31,32]. Aging accelerates the incidence of neurodegenerative disorders and gut dysbiosis, which causes inflammatory bowel disease (IBD) [33,34]. Patients with IBD display cognitive impairments and psychomotor performance, particularly during the active stage of the disease [35,36].…”

National Trends in Hospitalization, Surgical Resection, and Comorbidities in Pediatric Inflammatory Bowel Disease in the United States, 2002-2015

“…This is in agreement with multiple studies which have similarly documented increasing hospitalizations in PIBD. 12,[25][26][27][28] However, some studies have reported stable or decreasing incidence of IBD in North America. 29,30 It is clear from these conflicting data, that overall trends in incidence and prevalence of IBD in the United States are not clearly established.…”