2004
DOI: 10.1128/jb.186.7.2164-2172.2004
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Abstract: Leptospira species colonize a significant proportion of rodent populations worldwide and produce life-threatening infections in accidental hosts, including humans. Complete genome sequencing of Leptospira interrogans serovar Copenhageni and comparative analysis with the available Leptospira interrogans serovar Lai genome reveal that despite overall genetic similarity there are significant structural differences, including a large chromosomal inversion and extensive variation in the number and distribution of i… Show more

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Cited by 401 publications
(445 citation statements)
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“…All these animals were identified as Cebus sp., as many of them are hybrids. Microscopic agglutination tests (MAT) were performed, according to recommended protocols (Faine et al 1999, WHO 2003, and included twenty-three WHO reference strains and a local isolate (serovar Copenhageni strain L1130) (Ko et al 1999, Nascimento et al 2004. Titers ≥1:100 were considered positive.…”
Section: Methodsmentioning
confidence: 99%
“…All these animals were identified as Cebus sp., as many of them are hybrids. Microscopic agglutination tests (MAT) were performed, according to recommended protocols (Faine et al 1999, WHO 2003, and included twenty-three WHO reference strains and a local isolate (serovar Copenhageni strain L1130) (Ko et al 1999, Nascimento et al 2004. Titers ≥1:100 were considered positive.…”
Section: Methodsmentioning
confidence: 99%
“…Recently, whole genome sequencing of the Leptospira interrogans serogroup interrogans [47] and lai [48] identified many genes with a potential role in disease pathogenesis. Genes involved in host cell membrane degradation and encoding proteases, which could participate in the mechanisms of endothelial damage, have been sequenced.…”
Section: Histological Findings and Pathophysiology In Human Pulmonarymentioning
confidence: 99%
“…Recently, the completion of the genome sequences of L. interrogans serovar Lai and L. interrogans serovar Copenhageni, both belonging to serogroup Icterohaemorrhagiae, was achieved (16,20). The Lai and Copenhageni sequenced strains were isolated from patients with severe leptospirosis in China (20) and Brazil (16), respectively.…”
mentioning
confidence: 99%