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Cited by 45 publications
(36 citation statements)
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“…This can be explained by the fact that most investigators have analyzed pharyngeal lesions as a homogeneous subgroup of HNSCCs, even though carcinoma of the pharynx can originate from the epi-, meso-, or hypopharynx with different prognostic features. Similarly to our data, overrepresentation of chromosome 8q was found by Bergamo et al (16) in laryngeal carcinomas, although their samples included only three tumors of the larynx. Altered expression of the c-MYC protein has been related to tumor progression and metastasis formation in HNSCCs (45).…”
Section: Discussionsupporting
confidence: 91%
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“…This can be explained by the fact that most investigators have analyzed pharyngeal lesions as a homogeneous subgroup of HNSCCs, even though carcinoma of the pharynx can originate from the epi-, meso-, or hypopharynx with different prognostic features. Similarly to our data, overrepresentation of chromosome 8q was found by Bergamo et al (16) in laryngeal carcinomas, although their samples included only three tumors of the larynx. Altered expression of the c-MYC protein has been related to tumor progression and metastasis formation in HNSCCs (45).…”
Section: Discussionsupporting
confidence: 91%
“…The overall CGH pattern of chromosomal changes was similar to that reported by others (13)(14)(15)(16)(17)(18)(19)(20). However, the average number of genetic alterations was significantly higher in hypopharyngeal tumors than in laryngeal lesions, which is probably associated with the aggressive phenotype.…”
Section: Discussionsupporting
confidence: 86%
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