2005
DOI: 10.1101/gr.3059305
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Abstract: We have sequenced the genome of a second Drosophila species, Drosophila pseudoobscura, and compared this to the genome sequence of Drosophila melanogaster, a primary model organism. Throughout evolution the vast majority of Drosophila genes have remained on the same chromosome arm, but within each arm gene order has been extensively reshuffled, leading to a minimum of 921 syntenic blocks shared between the species. A repetitive sequence is found in the D. pseudoobscura genome at many junctions between adjacent… Show more

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Cited by 467 publications
(525 citation statements)
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References 93 publications
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“…Indeed, extant sequences of polymorphic inversion breakpoints are expected to better reflect the sequences in the original inverted chromosome. Despite the extensive knowledge accumulated on inversion polymorphism in Drosophila, there are relatively few polymorphic inversion breakpoints molecularly characterized both in any particular species and across species (but see Wesley and Eanes, 1994;Andolfatto et al, 1999;Cáceres et al, 1999;Casals et al, 2003;Matzkin et al, 2005;Richards et al, 2005;Delprat et al, 2009;Papaceit et al, 2013;Puerma et al, 2014). The number of molecularly characterized breakpoints drops even more when inversions with cytological evidence of reused breakpoints are considered Puerma et al, 2014).…”
Section: Introductionmentioning
confidence: 99%
“…Indeed, extant sequences of polymorphic inversion breakpoints are expected to better reflect the sequences in the original inverted chromosome. Despite the extensive knowledge accumulated on inversion polymorphism in Drosophila, there are relatively few polymorphic inversion breakpoints molecularly characterized both in any particular species and across species (but see Wesley and Eanes, 1994;Andolfatto et al, 1999;Cáceres et al, 1999;Casals et al, 2003;Matzkin et al, 2005;Richards et al, 2005;Delprat et al, 2009;Papaceit et al, 2013;Puerma et al, 2014). The number of molecularly characterized breakpoints drops even more when inversions with cytological evidence of reused breakpoints are considered Puerma et al, 2014).…”
Section: Introductionmentioning
confidence: 99%
“…This is directly testable owing to the chromosome arrangement in D. pseudoobscura, in which the ancestral autosome, Muller D, fused to the X chromosome ,8-12 million years ago 10 . The neo-X chromosome (Fig.…”
mentioning
confidence: 99%
“…The fly research community has sequenced, assembled and annotated the genomes of 12 Drosophila species 22,31,32 at a range of evolutionary distances from D. melanogaster (Fig. 1a, b).…”
mentioning
confidence: 99%