Comparative fading responses induced by mivacurium, cisatracurium, and d-tubocurarine in the evoked muscular compound action potentials of the cat

Abstract

Our results suggest that mivacurium shows a lesser degree of fade during partial neuromuscular block than cisatracurium and d-tubocurarine.

Train-of-four ratio recovery often precedes twitch recovery when neuromuscular block is reversed by sugammadex

“…Although there is a difference between currently used NMBAs in their ability to produce fade, during spontaneous recovery from NMB, the fade effect persists longer than twitch depression 25–28 . Fade disappears and the TOF ratio recovers to >0.9 only after normalization of T1 tension 24 .…”

“…Different non‐depolarizing NMBAs produce different degrees of fading response 25–27 . This is probably due to a difference in the potency of the NMBAs in blocking the neuronal pre‐synaptic nAChR.…”

Neuromuscular blockade effects of cisatracurium in 11 cats undergoing ophthalmological surgery anaesthetised with isoflurane

“…3,4 Moreover, the various degrees of fade induced by non-depolarising NMB agents in repetitive muscular contractions may be due to the varying affinities or binding kinetics of pre- and post-synaptic nicotinic receptors. 13 It is also important to note the difficulty in placing the electrodes because of the size of patient and that unintended displacement of the patient or the electrodes may occur during the intervention.…”