2012
DOI: 10.1016/j.meegid.2011.12.011
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Abstract: Evolutionary studies on dengue virus have frequently focused on intra-serotype diversity or on specific epidemics. In this study, we compiled a comprehensive data set of the envelope gene of dengue virus serotypes and conducted an extensive comparative study of evolutionary molecular epidemiology. We found that substitution rates are homogeneous among dengue serotypes, although their population dynamics have differed over the past few years as inferred by Bayesian coalescent methods. On a global scale, DENV-2 … Show more

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Cited by 70 publications
(69 citation statements)
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“…Various genomic regions of DENV have been used for molecular phylogenetic analyses [11][12], [40][43], and the E gene appears to have epidemiologically relevant sequence information [11], [41][42]. In this work, we have reconstructed the phylogeographic history of DENV-2 in Brazil, and for the first time, we have included samples from the state of Piauí collected during the 2006/2007 outbreak.…”
Section: Discussionmentioning
confidence: 99%
“…Various genomic regions of DENV have been used for molecular phylogenetic analyses [11][12], [40][43], and the E gene appears to have epidemiologically relevant sequence information [11], [41][42]. In this work, we have reconstructed the phylogeographic history of DENV-2 in Brazil, and for the first time, we have included samples from the state of Piauí collected during the 2006/2007 outbreak.…”
Section: Discussionmentioning
confidence: 99%
“…The calibration point was the year each strain was isolated/ obtained. Different runs were performed using the nucleotide substitution model GTR?G (four gamma categories), the Bayesian skyline plot (BSL), under strict or relaxed (uncorrelated lognormal) molecular clock, estimating the nucleotide evolutionary rate or using the previous estimated rate for DENV1 of 7.50 9 10 -4 substitutions per site per year, as described previously [28]. The molecular clock and rate that best fit the data was chosen by Bayes factor (BF) comparison, performed with Tracer v.1.5.0 [29].…”
Section: Sequence Analysismentioning
confidence: 99%
“…The vast distribution of mosquito vectors, which is fueled by frequent human migration, and inadequate listed vaccines and effective drugs, have resulted in a dramatic increase in DENV infections, which have undergone 30-fold growth over the last 50 years. The World Health Organization has estimated that more than 50-100 million DENV infections occur in over 100 countries annually, putting almost 2.5 billion people at risk (Costa et al, 2012).…”
Section: Introductionmentioning
confidence: 99%