Comparative evaluation of two commercial enzyme immunoassays for serodiagnosis of human parvovirus B19 infection

Risk of fetal hydrops and non-hydropic late intrauterine fetal death after gestational parvovirus B19 infection

“…In particular the detection of low titre B19 IgM may be due to late convalescence or false positivity. [17][18][19][20] To pinpoint the gestational age at the time of maternal B19 infection most accurately, we considered in the final analysis only women who had a B19 IgG seroconversion or an initially high positive B19 IgM test result. For this purpose, a B19 IgM cut off value was arbitrarily chosen following our previous findings on IgM antibody kinetics in pregnant women with acute B19 infection where B19 IgM index values ≥4.0 had a high predictive value for acute B19 infection within the last 4 weeks.…”

False-negative serology in patients with acute parvovirus B19 infection

“…Both tests were evaluated in a comparative study and showed equivalent specificity and sensitivity. 21 …”

Unusual high rate of asymptomatic maternal parvovirus B19 infection associated with severe fetal outcome

“…Newer studies show that novel commercial enzyme immunoassays with recombinant proteins have very high specificity and sensitivity detecting IgM antibodies and even higher detecting IgG antibodies to parvovirus B19 [14]. Therefore, relatively high percentage of acute infection found in our study cannot be attributed to false positive results.…”