Comparative evaluation of sutures coated with triclosan and chlorhexidine for oral biofilm inhibition potential and antimicrobial activity against periodontal pathogens: An in vitro study

Sethi, Kunal Sunder; Karde, Prerna Ashok; Joshi, Chaitanya

doi:10.4103/0970-9290.195644

Cited by 18 publications

(14 citation statements)

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“…They can contribute to inflammatory reactions and differ between patients. [ 10 16 ] Previous studies have investigated the wicking effect of silk[ 7 17 ] and show similar results to our study. Granet et al .…”

Section: Discussionsupporting

confidence: 89%

Effect of hyaluronic acid added to suture material and its relationship with bacterial colonization: An in vitro study

Sudhir

Thomas²,

Ramesh³

et al. 2018

J Int Soc Prevent Communit Dent

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Aims and Objectives:The aims of this study were to evaluate the presence of Staphylococcus aureus and Escherichia coli, in polyglycolic acid (PGA) 4-0 and silk sutures, with or without hyaluronic acid (HA) treatment.Materials and Methods:This in vitro study measured S. aureus and E. coli growth on PGA and silk sutures, through incubation in agar media for 24 h. The suture length was 10 cm and divided into three parts: A (8 h), B (16 h), and C (24 h), which were observed every 8 h, followed by suspension on a microscopic slide. This was repeated thrice. The number of S. aureus and E. coli cells was recorded and compared between the suture types.Results:The mean S. aureus colony forming units (CFUs) differed at each time point between non-HA and HA-PGA sutures (P = 0.0016), with a greater number of CFUs on non-HA-PGA. The mean S. aureus CFUs were significantly higher on non-HA silk than on HA-silk sutures (P = 0.008). There was a significant increase in E. coli CFUs on non-HA silk than on HA-silk sutures (P = 0.008). E. coli CFUs were higher on non-HA-PGA than on HA-PGA sutures (P = 0.006). We performed repeated measures two-way ANOVA (SPSS version 13.0) for comparison between group factors and time points and Posthoc analysis using independent samples t-test.Conclusions:HA reduced wicking in both PGA and silk sutures.

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Section: Discussionsupporting

confidence: 89%

Effect of hyaluronic acid added to suture material and its relationship with bacterial colonization: An in vitro study

Sudhir

Thomas²,

Ramesh³

et al. 2018

J Int Soc Prevent Communit Dent

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“…In view of the peculiarities of the oral cavity and the absence of an ideal suture the use of antimicrobial solutions for mouthwash is among the main postoperative recommendations 2 . Chlorhexidine gluconate (0.12%) is the most indicated antimicrobial because it has a broad spectrum of action 6,15 . However, the dose-response effect through indiscriminate use may affect the viability of epithelial cells and fibroblasts, interfering in the regulation of proinflammatory cytokines and growth factors, contradictorily, hindering tissue repair and increasing the resistance of microorganisms 23 .…”

Section: Discussionmentioning

confidence: 99%

“…Some factors, such as the diversity of microorganisms, the presence of saliva, rich vascularization, contamination by food residues and trauma resulting from speech and hygiene increase the inflammatory process, the healing time and the discomfort of the patient 5 . In addition, removal of the suture in infectious areas may lead to bacteremia which is a risk factor for the development of bacterial endocarditis in high-risk patients 6 .…”

Section: Introductionmentioning

confidence: 99%

Sutures modified by incorporation of chlorhexidine and cinnamaldehyde: anti-Candida effect, bioavailability and mechanical properties

Costa

Cavalcanti

Valença

et al. 2019

Rev. odontol. UNESP

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Introduction Antimicrobial sutures are a therapeutic alternative for the control of oral infections. Objective Incorporate Chlorhexidine (CHX) and Cinnamaldehyde (CN) in sutures and evaluate the anti-Candida effect, release of antimicrobials and mechanical properties. Material and method Silk (S) and Polyglactin 910 (P) sutures were aseptically sectioned (20 mm) and immersed for incorporation in 0.12% CHX, 0.4% CN and 0.9% saline solutions under stirring for 60 minutes (n = 10 / group). Suspensions of 500 μL of Candida albicans (ATCC 90028/ 1 × 106 CFU/mL) were used to evaluate fungal adhesion after the 48 h period at 37°C. The release of CLX and CN were evaluated at 0, 24 and 48 hours (n=3/group) by UV-VIS spectrophotometer (275 nm). The tensile strength and displacement (n=5/group) were evaluated after incorporation (30 mm/min, 50N). Data were analyzed by Anova and Tukey (α = 5%). Result No anti-Candida effect was observed on S and P sutures incorporated with CLX and CN (p>0.05). However, progressive release was verified up to 48 after treatment with CLX (S = 0.075 / P = 0.073 μg/mL) and CN (S = 35.33 /P= 5.72 μg/mL). There was a decrease in tensile strength in S (CLX = 9.9 / CN = 9.9 N) and P (CLX = 14.4 / CN = 15.5 N) (p<0.05). No differences were observed for the displacement for S (CLX = 19.3 / CN=20.7 mm) and P (CLX = 16.2 / CN=15.8 mm) (p>0.05). Conclusion The incorporation of CLX and CN did not have a positive effect on the biological and mechanical properties of the sutures evaluated.

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“…Sethi et al . [17] concluded that both triclosan- and chlorhexidine-coated sutures have antibacterial property against periodontal pathogens and can have a promising role in the prevention of SSIs although it would require further in vivo validation. According to Zeiler and Grohe[18], ciprofloxacin showed rapid bactericidal action against organisms in both the logarithmic and stationary growth phases.…”

Section: Discussionmentioning

confidence: 99%

In vitro antibacterial efficacy of sutures coated with Aloe vera and ciprofloxacin: A comparative evaluation

et al. 2019

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Background: Sutures which are used for wound approximation can act as a reservoir of microbes at the surgical site leading to increased chances of surgical site infection (SSI). Sutures used in oral cavity are continuously bathed in saliva which results in wicking. Several studies on sutures treated with nanoparticles, antibacterial agent and various drugs to advance the therapeutical value of surgical sutures are in consideration, drug-eluting sutures has been notable in research to deliver localized effect on the site of incision. Ciprofloxacin and Aloe vera are routinely used agents in coating sutures. Aim: This study is to evaluate the antibacterial efficacy and oral biofilm inhibition of Ciprofloxacin and Aloe vera coated 3-0 silk sutures in comparison to uncoated sutures against E.coli. Material and Methods: Equal segments of ciprofloxacin and aloe vera coated 3-0 silk sutures are to be incubated in E.coli culture media (blood agar) at 37°C for 24 hours in aerobic atmosphere. Plain uncoated suture served as control. Assessment was done using Total Colony Forming Units and biofilm inhibition potential of sutures. Results awaited. Results: The zone of inhibition around ciprofloxacin coated suture is nearly double than that of with Aloe vera indicted that antibacterial efficacy of ciprofloxacin is more comparatively. No inhibition zone around uncoated plain 3-0 braided silk shows that it has no significant antibacterial activity. Conclusion: Within limitation of our study, it can be concluded that both ciprofloxacin and Aloe vera coated sutures have antibacterial property against gram negative E. coli and can have a promising role in prevention of SSI although it would require further in vivo validation.

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Comparative evaluation of sutures coated with triclosan and chlorhexidine for oral biofilm inhibition potential and antimicrobial activity against periodontal pathogens: An in vitro study

Abstract: The antibacterial coated sutures have a promising potential in preventing the colonization of periodontal pathogens around it thereby inhibiting biofilm formation.

Cited by 18 publications

References 0 publications

Effect of hyaluronic acid added to suture material and its relationship with bacterial colonization: An in vitro study

Effect of hyaluronic acid added to suture material and its relationship with bacterial colonization: An in vitro study

Sutures modified by incorporation of chlorhexidine and cinnamaldehyde: anti-Candida effect, bioavailability and mechanical properties

In vitro antibacterial efficacy of sutures coated with Aloe vera and ciprofloxacin: A comparative evaluation

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