Comparative Evaluation of Remineralizing Potential of a Paste Containing Bioactive Glass and a Topical Cream Containing Casein Phosphopeptide-Amorphous Calcium Phosphate: An in Vitro Study

Abstract

Objective: To evaluate and compare the remineralization potential of a dentifrice containing bioactive glass and a topical cream containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) in remineralizing artificial carious lesion on enamel. Material and Methods: Forty-five freshly extracted human permanent premolar teeth were selected. Samples were divided into three groups: GI-regular tooth paste without specific remineralizing agent; GII-tooth paste containing calcium sodium-phosphosilicate (novamin) and GIII-topical cream containing casein phosphopeptide-amorphous calcium phosphate. All the sound enamel samples were viewed under scanning electron microscope (SEM) to assess the topographical pictures of enamel surface and energy dispersing x-ray analysis (EDAX) was done to estimate quantitatively the amounts of mineral (calcium and phosphorous). The mineral content of calcium and phosphorus after demineralization in each group was noted. The samples were then subjected to SEM and EDAX. Results: GI does not show any increase in the calcium and phosphorus after applying toothpaste without any remineralizing agent but GII and GIII showed a net increase in calcium and phosphorous values after applying concern-remineralizing agents. Inter group comparison showed GIII yield higher net calcium and phosphorous values than GII. Conclusion: Two remineralizing agents showed remineralization potential on enamel surfaces. Casein phosphopeptide-amorphous calcium phosphate showed better remineralizing potential than calcium sodium phosphosilicate. Hence CPP-ACP can be considered as the material of choice in remineralizing early enamel carious lesions.

Nanoparticles as Anti-Microbial, Anti-Inflammatory, and Remineralizing Agents in Oral Care Cosmetics: A Review of the Current Situation

“…Calcium sodium-phosphosilicate toothpaste was more effective in increasing acid resistance compared with CCP-ACP NP toothpaste [291]. Rajendran and colleagues showed, in vitro, that toothpaste containing BAG NPs (calcium sodium-phosphosilicate) was less effective than toothpaste containing CPP-ACP NPs to remineralize the enamel of carious lesions [292]. Even if the new HA layer formed in response to the presence of BAG NPs is similar to those of enamel or dentine, it presents better resistance to abrasion [293].…”

Impact of Two Remineralizing Agents on White Spot Lesions

“…Group (A): Control group teeth were placed in arti cial saliva to prevent dehydration. (2) Group (B):…”

“…That is why it is important to prevent the progression of caries at early stages, instead of developing treatment procedures to treat its advanced stages. (2) White spot lesions are the earliest macroscopic evidence of enamel caries. Early stages of tooth demineralization are reversed by saliva, which contains uoride, calcium, and phosphate ions, buffering agents, and other substances.…”

A Retrospective Analysis of The Correlation Between the Type of Pulp Exposure and The Choice of Pulp Capping Agents

“…Calcium hydroxide (CaOH) and Mineral Trioxide Aggregate (MTA) were mainly considered as the common choice of materials for the direct and indirect pulp capping method (Jose et al, 2020). Among the materials Calcium hydroxide (Rajendran et al, 2019) is to be considered as the gold standard choice of the material which can be used as a standard choice against the other newer materials in order for the comparative studies. In the early 1900s, the MTA was discovered which mainly had various uses and advantages in the clinical dentistry of its application (Rajendran et al, 2019;R and Ms, 2019).…”

“…Among the materials Calcium hydroxide (Rajendran et al, 2019) is to be considered as the gold standard choice of the material which can be used as a standard choice against the other newer materials in order for the comparative studies. In the early 1900s, the MTA was discovered which mainly had various uses and advantages in the clinical dentistry of its application (Rajendran et al, 2019;R and Ms, 2019). There are various studies which showed that MTA tends to produce less pulpal in lammation and forms a more predictable hard tissue barrier formation when it is compared to hard setting calcium hydroxide (Manohar and Sharma, 2018;Noor and Pradeep, 2016).…”