Comparative evaluation of extracts of<i>Citrus limon</i>burm peel for antioxidant activity

S, Akhila; Ar, Bindu; Bindu, Karra Hima; Aleykutty, NA

doi:10.4103/0975-1483.55746

Cited by 21 publications

(14 citation statements)

References 5 publications

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“…Ascorbic acid [206]. Flavonoid dimethylnobiletin [207] Antioxidative in diabetic rats [202,203]. Increases glucose uptake by skeletal muscle cells in an AMPK-dependent manner [204].…”

mentioning

confidence: 99%

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

2011

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“…Ascorbic acid [206]. Flavonoid dimethylnobiletin [207] Antioxidative in diabetic rats [202,203]. Increases glucose uptake by skeletal muscle cells in an AMPK-dependent manner [204].…”

mentioning

confidence: 99%

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

2011

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“…16 Recently, the research-based focus is on the usage of natural antioxidants for obliterating the free radicals mediated skin damage. Because most antioxidant molecules are inherently unstable in nature, 17 it makes them difficult to formulate in an acceptable, stable aesthetic product for cosmetic use. Further, the use of conventional delivery systems in several cases showed a little or no improvement in antioxidant profile.…”

Section: Introductionmentioning

confidence: 99%

Self-nanoemulsifying Drug Delivery System (Snedds) for Topical Delivery of Mangosteen Peels (Garcinia Mangostana L.,): Formulation Design and In vitro Studies

Pratiwi¹,

Fudholi²,

Martien³

et al. 2017

JYP

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Objective: Purpose of this research was to get the optimum formulation of Self-Nanoemulsifying Drug Delivery System (SNEDDS) of mangosteen peels and to evaluate the permeation ability of active substances in the formulation. Method: Oil phase solubility of ethanol extract, ethyl acetate extract, ethyl acetate fraction, n-hexane fraction and residue of the mangosteen peels was tested with virgin coconut oil (VCO). The formulation was designed with a simplex lattice design using Design Expert software and the permeation was tested using Franz diffusion cell. Results: Based on the results of simplex lattice design methods obtained that the optimum formulation of SNEDDS was the composition of VCO, Tween 80, PEG 400 at a ratio of 1:6,95:2,05. The results of permeation test in vitro using Franz Diffusion cell indicated that the obtained SNEDDS ethyl acetate fraction of mangosteen peels that is 96.9223% higher than without preparation SNEDDS was 18,9426 % on hour-8. The optimum physical evaluation SNEDDS optimum values obtained involved drug loading of 125mg/5 mL SNEDDS, the transmittance value of 92%, emulsification time of 65 seconds, pH of 6.35, particle size 20 nm, zeta potential -12,40 and stable for three months. Conclusion: SNEDDS can improve the diffusion rate of mangosteen peels as a model poorly water soluble drug.Various samples of mangosteen peels were screened as candidates for SNEDDS on the basis of solubility of the active compound in oils, surfactants, and co-surfactants. Simplex lattice design methods can be used to obtain optimum formulation on SNEDDS.Key words: SNEDDS, Extract, Fraction, Mangosteen Peels, Simplex Lattice Design.Key message: Novelty in this research is the utilization of waste mangosteen peels in ethanol extract, ethyl acetate extract, ethyl acetate fraction, n-hexane fraction and residue designed SNEDDS. SNEDDS designed with the simplex lattice design route topical are something new. Additionally, it appeared that diffusion for in vitro release from these SNEDDS. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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“…Herbs like turmeric, 1 fenugreek, ginger, garlic and holy basil 2 are integral part of Ayurvedic formulation. There have been several studies on the anti oxidant activities of various herbs 3 /plants 4 /extracts 5 with medicinal val ues. However, the exact mechanism and mode of action of these formu lations/extracts is not known.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Assessment of Antioxidant Activities of Apigenin Isomers: Vitexin and Isovitexin

Khole

Panat

Suryawanshi

et al. 2016

FRA

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Introduction: Fenugreek is known to possess anti-diabetic as well as antioxidant properties known to increase with germination. Previous study from our laboratory has reported vitexin and isovitexin as major antioxidant compounds from germinated fenugreek seeds. The present study aimed to comprehensively assesses and compare their antioxidant activity. Methods: The antioxidant ability of these compounds against various radicals was checked using standard in vitro radical scavenging assays and pulse radiolysis. Protection conferred to mitochondria against oxidative damage was assessed by measuring the levels of lipid peroxides and protein sulphydryls. Protection from hydrogen peroxide induced cytotoxicity in HepG2 cells was checked by MTT assay and by measuring intracellular ROS. Their ability to modulate intracellular antioxidant status was checked both at activity and RNA level. Result: Vitexin and isovitexin exhibited differential antioxidant activity against various radicals. Vitexin was a better nitric oxide scavenger while isovitexin scavenged superoxide radicals more efficiently. Pulse radiolysis studies revealed good antioxidant activity of both compounds against short-lived radicals and affected the formation and decay of the 2-dG transient species to the same extent. In oxidatively damaged mitochondria, lipid peroxidation was inhibited significantly by isovitexin whereas vitexin prevented decrease in protein sulphydryl content more effectively. These compounds protected HepG2 cells to the same extent against hydrogen peroxide induced oxidative insult by reducing intracellular ROS and modulating the levels of antioxidant enzymes. Conclusion: The present study clearly demonstrates differential antioxidant potential of both vitexin and isovitexin and their role in mitigating oxidative stress induced damage and maintaining cellular redox homeostasis.

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Comparative evaluation of extracts ofCitrus limonburm peel for antioxidant activity

Cited by 21 publications

References 5 publications

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

Self-nanoemulsifying Drug Delivery System (Snedds) for Topical Delivery of Mangosteen Peels (Garcinia Mangostana L.,): Formulation Design and In vitro Studies

Comprehensive Assessment of Antioxidant Activities of Apigenin Isomers: Vitexin and Isovitexin

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