Comparative evaluation of biphasic calcium phosphate and biphasic calcium phosphate collagen composite on osteoconductive potency in rabbit calvarial defect

Abstract

BackgroundThe aim of this study was to determine the osteoconductivity of biphasic calcium phosphate collagen composite (BCPC) in rabbit calvarial defect model by comparing with biphasic calcium phosphate (BCP). Four 8 mm diameter bicortical calvarial defects were made in ten rabbits. Each of the defects was randomly assigned and filled with 1) collagen sponge, 2) BCP, 3) BCPC, and 4) nothing as control. The animals were sacrificed at either 2 weeks (n = 5) or 8 weeks (n = 5) healing period.ResultsAll groups showed wedge shaped new bone formation limited to the area of the defect margin at both healing periods. The amounts of new bone and defect closure were similar among all groups. In the control and collagen sponge group, the center of the defect was depressed by surrounding tissues. In contrast, in BCP and BCPC group, the center of the defect did not depressed and the grafted materials maintained the space. And the augmented area was significantly higher in BCP and BCPC group compared to the control and collagen sponge group at both healing periods (p < 0.05).ConclusionsThe BCPC and BCP demonstrated proper space maintaining capacity and osteoconductive property, suggesting BCPC can be efficiently utilized in various clinical situations.

Biomimetic hydroxyapatite used in the treatment of periodontal intrabony pockets: clinical and radiological analysis

“…It allows the progressive releasing of these factors, able to induce migration, adhesion and proliferation of cells inside the pore network and to promote a faster angiogenesis and a more effective osteo-genesis inside these pores (19)(20)(21). Theoretical data was confirmed by clinical outcome (22). In fact, according to several studies (23)(24)(25)(26), new generation hydroxya- (27).…”

Bone formation following sinus grafting with an alloplastic biphasic calcium phosphate in Lanyu Taiwanese mini‐pigs

“…37 The most commonly used calcium phosphate ceramics are HA and -TCP at various weight ratios. 41,42 The high biocompatibility, increase safety, high predictability, unlimited availability, low morbidity for patients, and cost-effectiveness of calcium phosphate ceramics all represent important advantages over autografts and allografts. 41,42 The high biocompatibility, increase safety, high predictability, unlimited availability, low morbidity for patients, and cost-effectiveness of calcium phosphate ceramics all represent important advantages over autografts and allografts.…”

“…[38][39][40] Calcium phosphate ceramics have shown bioactivity and osteoconductivity in previous papers. 41,42 The high biocompatibility, increase safety, high predictability, unlimited availability, low morbidity for patients, and cost-effectiveness of calcium phosphate ceramics all represent important advantages over autografts and allografts. 43 Although the ideal ratio of HA to -TCP is still under investigation, [44][45][46] variant ratios of BCPs have been widely used for bone graft substitutes, with favorable results A review of the commercially available BCP indicated that the most common ratio is 60% HA and 40% -TCP.…”

An Overview of Biomaterials in Periodontology and Implant Dentistry

“…Bone graft materials are used as scaffold or filler to promote bone formation and wound healing. These materials are broadly divided into autograft, allograft, xenograft, and alloplast (Table 2), which act as a mineral reservoir to assist new bone formation [23,24]. [50].…”