2021
DOI: 10.1200/jco.2021.39.15_suppl.7535
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Abstract: 7535 Background: Chimeric antigen receptor T-cell therapies tisa-cel and liso-cel are effective treatments for r/r DLBCL (Schuster 2019, Abramson 2020). This study compared efficacy outcomes of tisa-cel and liso-cel in r/r DLBCL using matching-adjusted indirect comparison (MAIC). Methods: Individual patient-level data (IPD) from JULIET (tisa-cel; NCT02445248; 02/2020 datacut) were weighted to match the patient population in TRANSCEND (liso-cel; NCT02631044; 08/2019 datacut). Baseline prognostic factors availa… Show more

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“…A recent MAIC analysis comparing efficacy-evaluable patients in JULIET (N = 115; data cutoff February 2020) to TRANSCEND (N = 256; data cutoff August 2019) was conducted to evaluate the comparative efficacy of tisagenlecleucel versus liso-cel, and found no evidence of differences in ORR, CR rate, OS, and PFS between the two CAR T-cell therapies [ 25 , 26 ]. Several of the following analytical approaches employed by the authors are worth noting: (1) 8 patients who did not receive lymphodepleting chemotherapy and 1 patient with DLBCL misclassification were first removed from the JULIET dataset before analysis (n = 106); (2) TRANSCEND enrolled a broader patient population (e.g., primary mediastinal B-cell lymphoma and follicular lymphoma grade 3B subtypes, ECOG PS of 2, secondary CNS lymphoma, prior allo-HSCT, impaired renal function, no prespecified threshold for blood counts) that could not be emulated using patients enrolled in JULIET; (3) proportion of patients who did not receive bridging therapy in JULIET (n = 11 of 106) was up-weighted from 10.4% to 42.4% to match that from TRANSCEND (n = 106 of 256).…”
Section: Discussionmentioning
confidence: 99%
“…A recent MAIC analysis comparing efficacy-evaluable patients in JULIET (N = 115; data cutoff February 2020) to TRANSCEND (N = 256; data cutoff August 2019) was conducted to evaluate the comparative efficacy of tisagenlecleucel versus liso-cel, and found no evidence of differences in ORR, CR rate, OS, and PFS between the two CAR T-cell therapies [ 25 , 26 ]. Several of the following analytical approaches employed by the authors are worth noting: (1) 8 patients who did not receive lymphodepleting chemotherapy and 1 patient with DLBCL misclassification were first removed from the JULIET dataset before analysis (n = 106); (2) TRANSCEND enrolled a broader patient population (e.g., primary mediastinal B-cell lymphoma and follicular lymphoma grade 3B subtypes, ECOG PS of 2, secondary CNS lymphoma, prior allo-HSCT, impaired renal function, no prespecified threshold for blood counts) that could not be emulated using patients enrolled in JULIET; (3) proportion of patients who did not receive bridging therapy in JULIET (n = 11 of 106) was up-weighted from 10.4% to 42.4% to match that from TRANSCEND (n = 106 of 256).…”
Section: Discussionmentioning
confidence: 99%