Comparative efficacy of epidural, subarachnoid, and intracerebroventricular opioids in patients with pain due to cancer

Intracerebroventricular opioids for intractable pain

“…The results of other studies are in agreement with those that are covered in the Cochrane review [29–36]. Serrié[37], in addition to measuring the analgesic effect, measured the levels of the morphine metabolite morphine‐6‐glucuronide (M6G) and suggests that the metabolite was responsible for 33–67% of the analgesic effect.…”

“…Despite some questioning early on of the rigour of ICV analgesic studies and possible confounding factors [16], subsequent studies seem to support the early promising results. A Cochrane review by Ballantyne and Carwood published in 2005 [17] assessed 13 trials [9, 12, 18–28] of ICV opioids. The majority of the reviewed studies, like the majority subsequently, did not quantify pain relief using a formal measure (e.g.…”

Intracerebroventricular opioids for intractable pain

“…The results of other studies are in agreement with those that are covered in the Cochrane review [29–36]. Serrié[37], in addition to measuring the analgesic effect, measured the levels of the morphine metabolite morphine‐6‐glucuronide (M6G) and suggests that the metabolite was responsible for 33–67% of the analgesic effect.…”

“…Despite some questioning early on of the rigour of ICV analgesic studies and possible confounding factors [16], subsequent studies seem to support the early promising results. A Cochrane review by Ballantyne and Carwood published in 2005 [17] assessed 13 trials [9, 12, 18–28] of ICV opioids. The majority of the reviewed studies, like the majority subsequently, did not quantify pain relief using a formal measure (e.g.…”

Intrathecal Drug Administration in Chronic Pain Syndromes

“…A Cochrane review reported a randomized controlled trial and several prospective and retrospective studies. The authors concluded that neuraxial opioid therapy is often effective for treating cancer pain that has not been adequately controlled by systemic treatment . This conclusion was confirmed in a more recent systematic review based on 5 studies examining only patients with cancer pain (1 randomized controlled trial and 4 observational studies).…”

Movement-evoked breakthrough cancer pain despite intrathecal analgesia: a prospective series

“…According to the standards of evidence‐based medicine, few high‐quality studies exist. However, reviewers in the field seem to agree that ITA is a valuable analgesic technique in intractable cancer‐related pain . We have shown that movement‐evoked BTP remains a significant problem for a substantial number of patients.…”

“…This field has produced numerous uncontrolled studies . One randomised, non‐blinded clinical trial showed improved cancer pain control and less drug toxicity with opioid‐ITA compared with comprehensive medical management .…”

Intracerebroventricular opioids for intractable pain

“…The results of other studies are in agreement with those that are covered in the Cochrane review [29–36]. Serrié[37], in addition to measuring the analgesic effect, measured the levels of the morphine metabolite morphine‐6‐glucuronide (M6G) and suggests that the metabolite was responsible for 33–67% of the analgesic effect.…”

“…Despite some questioning early on of the rigour of ICV analgesic studies and possible confounding factors [16], subsequent studies seem to support the early promising results. A Cochrane review by Ballantyne and Carwood published in 2005 [17] assessed 13 trials [9, 12, 18–28] of ICV opioids. The majority of the reviewed studies, like the majority subsequently, did not quantify pain relief using a formal measure (e.g.…”

Intrathecal Drug Administration in Chronic Pain Syndromes

“…A Cochrane review reported a randomized controlled trial and several prospective and retrospective studies. The authors concluded that neuraxial opioid therapy is often effective for treating cancer pain that has not been adequately controlled by systemic treatment . This conclusion was confirmed in a more recent systematic review based on 5 studies examining only patients with cancer pain (1 randomized controlled trial and 4 observational studies).…”

Movement-evoked breakthrough cancer pain despite intrathecal analgesia: a prospective series

“…According to the standards of evidence‐based medicine, few high‐quality studies exist. However, reviewers in the field seem to agree that ITA is a valuable analgesic technique in intractable cancer‐related pain . We have shown that movement‐evoked BTP remains a significant problem for a substantial number of patients.…”

“…This field has produced numerous uncontrolled studies . One randomised, non‐blinded clinical trial showed improved cancer pain control and less drug toxicity with opioid‐ITA compared with comprehensive medical management .…”

Intracerebroventricular opioids for intractable pain

“…The results of other studies are in agreement with those that are covered in the Cochrane review [29–36]. Serrié[37], in addition to measuring the analgesic effect, measured the levels of the morphine metabolite morphine‐6‐glucuronide (M6G) and suggests that the metabolite was responsible for 33–67% of the analgesic effect.…”

“…Despite some questioning early on of the rigour of ICV analgesic studies and possible confounding factors [16], subsequent studies seem to support the early promising results. A Cochrane review by Ballantyne and Carwood published in 2005 [17] assessed 13 trials [9, 12, 18–28] of ICV opioids. The majority of the reviewed studies, like the majority subsequently, did not quantify pain relief using a formal measure (e.g.…”

Intrathecal Drug Administration in Chronic Pain Syndromes

“…A Cochrane review reported a randomized controlled trial and several prospective and retrospective studies. The authors concluded that neuraxial opioid therapy is often effective for treating cancer pain that has not been adequately controlled by systemic treatment . This conclusion was confirmed in a more recent systematic review based on 5 studies examining only patients with cancer pain (1 randomized controlled trial and 4 observational studies).…”

Movement-evoked breakthrough cancer pain despite intrathecal analgesia: a prospective series

“…According to the standards of evidence‐based medicine, few high‐quality studies exist. However, reviewers in the field seem to agree that ITA is a valuable analgesic technique in intractable cancer‐related pain . We have shown that movement‐evoked BTP remains a significant problem for a substantial number of patients.…”

“…This field has produced numerous uncontrolled studies . One randomised, non‐blinded clinical trial showed improved cancer pain control and less drug toxicity with opioid‐ITA compared with comprehensive medical management .…”