Comparative effects of zinc oxide and zinc oxide nanoparticle as feed additives on growth, feed choice test, tissue residues, and histopathological changes in broiler chickens

Radi, Abeer M.; Azeem, Naglaa M Abdel; El‐Nahass, El‐Shaymaa

doi:10.1007/s11356-020-09888-6

Cited by 15 publications

(12 citation statements)

References 36 publications

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“…Additionally, in Zaghari et al (2013), a reduction in triglyceride and an increase in LDL in serum were observed in birds fed a diet supplemented with 100 mg ZnO. In agreement with these findings, other studies Sarvari et al (2015) and Hussan et al (2022) and Radi et al (2021) showed that ZnO NP supplementation did not influence cholesterol and serum protein concentrations at 42 days of age. Oxidative stress is primarily uncovered via the modulation of the antioxidant enzyme and the downregulation of the nonenzymatic antioxidants.…”

Section: Discussionsupporting

confidence: 83%

“…In our study, the histopathologic examination of different tissues supports the chemical, immune-related, and oxidative findings, where there was dose-dependent damage in the liver, kidney, spleen, bursa, and thymus, which may be correlated to the dose-dependent oxidative damage described above. Limited studies are available regarding the detailed description of histopathologic changes associated with Zn (Wight et al 1986 ) or ZnO NPs (El-Katcha et al 2017a ; Radi et al 2021 ). At the same time, no previous studies are available regarding the description of such pathologic lesions in lymphoid organs.…”

Section: Discussionmentioning

confidence: 99%

“…Newly, trace minerals, including Zn nanoparticles, can be successfully used to fulfill the needs of minerals in bird diets (Dosoky et al 2021 ; El-Seedi et al 2019 ; Mohammed et al 2020 ; Sizova et al 2020 ) based on their extremely small size and specific physical properties (Biria et al 2020 ; Fouda et al 2021 ; Radi et al 2021 ). Nanoparticles can successfully supply minerals in birds and enhance the growth rate and feed utilization (Abdel-Daim et al 2019 , Abdelsalam et al 2019 , Bhattacharya et al 2021 , Fouda et al 2020 , Gangadoo et al 2016 , Hafez et al 2017 , Ibrahim et al 2021 , Kandeil et al 2019 , Mohammed and Safwat 2020 , Oberdörster et al 2005 ).…”

Section: Introductionmentioning

confidence: 99%

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Zinc oxide nanoparticles induce dose-dependent toxicosis in broiler chickens reared in summer season

Dosoky

Albanna

Zahran

et al. 2022

Environ Sci Pollut Res

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This research evaluates the effect of dietary zinc oxide nanoparticles’ (ZnO NPs) supplementation on growth performance, immunity, oxidative antioxidative properties, and histopathological picture of broiler chicken reared in the summer season. A total of 224 1-day-old male Cobb chicks were randomly allocated to seven groups of dietary treatments (n = 32). Seven isocaloric and isonitrogenous diets were formulated. ZnO NPs were added to the basal diet at seven different levels, 0, 5, 10, 20, 40, 60, and 80 ppm/kg diet, respectively, for 35 days. Results indicated that live body weight (g) did not differ significantly (P > 0.05) between treatment groups, whereas compared to control, the 5 ppm ZnO NPs/kg diet recorded the highest live body weight at 21 and 35 days. No significant effects for the feed consumption (g/bird/period) and feed conversion ratio (g feed/g gain) among treated and control birds were observed. Hematological and immunological variables showed significant (P ≤ 0.05) dose-dependent modulations by ZnO NP supplementation. Significant (P ≤ 0.05) differences were observed in the phagocytic activity, phagocytic index, and IgM and IgG between the treatment groups, with the 5 and 10 ppm ZnO NPs/kg diet recording the best values, followed by the 20 ppm ZnO NPs/kg diet. Different supplementations had nonsignificant effects on the digestibility of nutrients (P ≤ 0.05). Histopathological pictures of the kidney, liver, and lymphoid organs, ultrastructural examination of muscle tissues, and expression of inflammatory cytokines showed dose-dependent morphological and structural changes. In conclusion, the ZnO NP supplementation in broiler diet to eliminate the heat stress hazards in summer season is recommended in dose level of not more than 10 ppm/kg diet.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Zinc oxide nanoparticles induce dose-dependent toxicosis in broiler chickens reared in summer season

Dosoky

Albanna

Zahran

et al. 2022

Environ Sci Pollut Res

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“…For Cu, decreasing of blood urea, [107] indicated its potential association with higher protein metabolism and higher use of amino acids for protein formation. Similar findings for CuNPs [108], ZnONPs [93,94,109].…”

supporting

confidence: 80%

“…Moreover, NPs can be rapidly cleared through the kidneys when the particle size is small [112] and this assessed in our nanocomposite characterization. The elevated Fe in studied hepatic tissues than those in muscular tissues was recorded [111], for using CuONP [102,113].or ZnONP [109,[114][115][116] may be due to the high production rate of metallothionein [117] since the liver act metal detoxification through metal sulfur-protein formation [118] and storing the excess Fe form of heme-protein and ferritin for various metabolic activities [119]. The less concentration of MONPs in the muscle may be due to the low level of metalbinding protein as MT in the muscle and owing to the large mass with low metabolic activity of muscular tissues [120].…”

mentioning

confidence: 92%

The efficacy of metal nanocomposite (Fe3O4/CuO/ZnO) to ameliorate the toxic effects of ochratoxin in broilers

2022

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Background The study aimed to investigate the effectiveness of different doses of metal nanocomposite (MNc) (Fe3O4/CuO/ZnO) lower than its cytotoxic level in order to overcome or minimize the ochratoxin (OTA) adverse effects in broilers fed on contaminated ration. The study conducted on 120 one-day old chicks which were divided into equal 6 groups; G1: negative control, G2: positive control (fed on OTA 17 ppb), G3& G4 (fed MNc only with low and high doses respectively). The rest two groups G5 & G6 (treatment groups) were fed on OTA, post induced ochratoxification, treated with low and high doses respectively. Results Body weight gain and heamatocellular elements in both treated groups increased significantly than control. Serum phagocytic nitric oxide levels were increased significantly in both treated groups than control groups. Prothrombin time (PT), Alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) activities decreased significantly (P < 0.05) in both treated groups than intoxicated control group (G2) but still higher than non-intoxicated control group (G1). Total protein, albumin, globulin, calcium and phosphorus increased significantly in both treated groups than intoxicated control group. Kidney function tests showed significant improvement in both treated groups than intoxicated control group. Antioxidant study revealed that malondialdehyde (MDA) decreased significantly in treated groups than intoxicated control group. Ochratoxin residue decreased significantly in treated groups. Metal residues in tested liver and muscle of treated groups showed no-significant difference with non-intoxicated control group (G1) at the experiment’s end. In conclusion, feeding either low or high doses of MNc to broilers were significantly counteracting the negative impacts of OTA or its residue and increase their body weight.

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Effects of Dietary Supplementation of Zinc Oxide Quantum Dots on Growth Performance and Gut Health in Broilers

Shi,

Ruan,

Zhang

et al. 2024

Biol Trace Elem Res

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Comparative effects of zinc oxide and zinc oxide nanoparticle as feed additives on growth, feed choice test, tissue residues, and histopathological changes in broiler chickens

Cited by 15 publications

References 36 publications

Zinc oxide nanoparticles induce dose-dependent toxicosis in broiler chickens reared in summer season

Zinc oxide nanoparticles induce dose-dependent toxicosis in broiler chickens reared in summer season

The efficacy of metal nanocomposite (Fe3O4/CuO/ZnO) to ameliorate the toxic effects of ochratoxin in broilers

Effects of Dietary Supplementation of Zinc Oxide Quantum Dots on Growth Performance and Gut Health in Broilers

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