Comparative effects of high intensity interval training versus moderate intensity continuous training on quality of life in patients with heart failure: Study protocol for a randomized controlled trial

Ulbrich, Anderson Zampier; Angarten, Vitor; Netto, Almir Schmitt; Sties, Sabrina Weiss; Bündchen, Daiana Cristine; Mara, Lourenço Sampaio de; Cornelissen, Véronique; Carvalho, Tales de

doi:10.1016/j.ctrsc.2015.11.005

Cited by 33 publications

(22 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…After the removal of duplicate records and the screening of abstracts and titles to assess relevance, 63 studies were selected for full-text review. After the exclusion of 40 articles which did not comply with the inclusion criteria, the final sample consisted of 23 articles [9, 10, 12, 13, 19–37] that reported on 21 studies. The characteristics of included studies are summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…The authors of 21 studies [9, 10, 12, 13, 19–37] involving 738 patients reported on peak oxygen uptake following INTERVAL and CONTINUOUS. Peak VO 2 improved by 1.76 mL/kg/min [95% confidence interval (CI) 1.06 to 2.46 mL/kg/min] among patients in the INTERVAL groups, which was greater than observed in the CONTINUOUS groups, based on a random-effects model (overall Z = 4.92, p < 0.001).…”

Section: Resultsmentioning

confidence: 99%

“…The authors of eight studies [9, 10, 13, 20, 25, 27, 28, 36] involving 376 patients reported on systolic blood pressure (SBP) and diastolic blood pressure (DBP) following INTERVAL and CONTINUOUS. A random-effects model revealed no significant difference between groups (SBP: MD −0.09 mmHg, 95% CI −4.82 to 4.65 mmHg, p = 0.97; DBP: MD −0.79 mmHg, 95% CI −3.75 to 2.16 mmHg, p = 0.60).…”

Section: Resultsmentioning

confidence: 99%

“…The authors of eight studies [9, 12, 19–21, 25, 26, 32] involving 170 patients reported increased LVEF following INTERVAL and CONTINUOUS. A random-effects model showed no significant difference between groups (MD 2.18%, 95% CI −0.54% to 4.90%, p = 0.12).…”

Section: Resultsmentioning

confidence: 99%

“…However, recent evidence from patients with CHF [9] and CAD [10] suggests that high-intensity interval training (INTERVAL) may be a better modality for the improvement of aerobic capacity. Although INTERVAL has no standard definition, it refers to repeated sessions of brief intermittent exercise, often performed with maximal effort or intensity (i.e., to achieve ≥90% peak VO 2 ) [11].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Effects of High-Intensity Interval Training on Aerobic Capacity in Cardiac Patients: A Systematic Review with Meta-Analysis

Xie

Yan

Cai

et al. 2017

BioMed Research International

View full text Add to dashboard Cite

Purpose. The aim of this study was to compare the effects of high-intensity interval training (INTERVAL) and moderate-intensity continuous training (CONTINUOUS) on aerobic capacity in cardiac patients. Methods. A meta-analysis identified by searching the PubMed, Cochrane Library, EMBASE, and Web of Science databases from inception through December 2016 compared the effects of INTERVAL and CONTINUOUS among cardiac patients. Results. Twenty-one studies involving 736 participants with cardiac diseases were included. Compared with CONTINUOUS, INTERVAL was associated with greater improvement in peak VO2 (mean difference 1.76 mL/kg/min, 95% confidence interval 1.06 to 2.46 mL/kg/min, p < 0.001) and VO2 at AT (mean difference 0.90 mL/kg/min, 95% confidence interval 0.0 to 1.72 mL/kg/min, p = 0.03). No significant difference between the INTERVAL and CONTINUOUS groups was observed in terms of peak heart rate, peak minute ventilation, VE/VCO2 slope and respiratory exchange ratio, body mass, systolic or diastolic blood pressure, triglyceride or low- or high-density lipoprotein cholesterol level, flow-mediated dilation, or left ventricular ejection fraction. Conclusions. This study showed that INTERVAL improves aerobic capacity more effectively than does CONTINUOUS in cardiac patients. Further studies with larger samples are needed to confirm our observations.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of High-Intensity Interval Training on Aerobic Capacity in Cardiac Patients: A Systematic Review with Meta-Analysis

Xie

Yan

Cai

et al. 2017

BioMed Research International

View full text Add to dashboard Cite

show abstract

Mitochondrial Therapies in Heart Failure

Hardenberg

Maack

2016

Heart Failure

View full text Add to dashboard Cite

The current therapy for patients with stable systolic heart failure is largely limited to treatments that interfere with neurohormonal activation. Critical pathophysiological hallmarks of heart failure are an energetic deficit and oxidative stress, and both may be the result of mitochondrial dysfunction. This dysfunction is not (only) the result of defect within mitochondria per se, but is in particular traced to defects in intermediary metabolism and of the regulatory interplay between excitation-contraction coupling and mitochondrial energetics, where defects of cytosolic calcium and sodium handling in failing hearts may play important roles. In the past years, several therapies targeting mitochondria have emerged with promising results in preclinical models. Here, we discuss the mechanisms and results of these mitochondria-targeted therapies, but also of interventions that were not primarily thought to target mitochondria but may have important impact on mitochondrial biology as well, such as iron and exercise. Future research should be directed at further delineating the details of mitochondrial dysfunction in patients with heart failure to further optimize these treatments.

show abstract

High-intensity exercise interventions in cancer survivors: a systematic review exploring the impact on health outcomes

Toohey

Pumpa

McKune

et al. 2017

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

High-intensity exercise interventions improved physical and physiological health-related outcome measures such as cardiovascular fitness and strength in cancer survivors. Given that high-intensity exercise sessions require a shorter time commitment, it may be a useful modality to improve health outcomes in those who are time poor. The risk of adverse events associated with high-intensity exercise was low.

show abstract

Comparative effects of high intensity interval training versus moderate intensity continuous training on quality of life in patients with heart failure: Study protocol for a randomized controlled trial

Cited by 33 publications

References 60 publications

Effects of High-Intensity Interval Training on Aerobic Capacity in Cardiac Patients: A Systematic Review with Meta-Analysis

Effects of High-Intensity Interval Training on Aerobic Capacity in Cardiac Patients: A Systematic Review with Meta-Analysis

Mitochondrial Therapies in Heart Failure

High-intensity exercise interventions in cancer survivors: a systematic review exploring the impact on health outcomes

Contact Info

Product

Resources

About