Comparative cytotoxic effects of five commonly used triazole alcohol fungicides on human cells of different tissue types

Xu, Jiuyong; Xiong, Hui; Zhang, Xianfei; Muhayimana, Solange; Li, Xuefeng; Xue, Yufan; Huang, Qingchun

doi:10.1080/03601234.2019.1709377

Cited by 8 publications

(6 citation statements)

References 40 publications

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“…Some studies have demonstrated that triadimefon has toxic effects on zebra sh and xenopus, likehormone dyscrasia and reproductive problems (Ma et al, 2020. Moreover, the metabolites of some pesticides, such as triadimefon and triadimenol, can induce cytotoxicity in human beings (Xu at al., 2020). Epoxiconazole is an inhibitor of 11 β-hydroxylase and aldosterone synthase, and prolonged exposure can cause cardiometabolic diseases, chronic kidney disease, mass, and immune-related disorders (Akram et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Uptake, translocation, and subcellular distribution of three triazole pesticides in rice

Wang

et al. 2021

Environ Sci Pollut Res

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Triazole pesticide is a widely-used pesticide for the control of pathogenic fungi in crops and its extensive use has caused food safety issues due to its uptake byedible crops. The residue of triazole pesticides has caused many toxicity risks and food safety problems. In this study, the uptake, translocation, and subcellular distribution of three triazole pesticides (triadimefon, tebuconazole, and epoxiconazole) in rice were investigated. The results showed that the three selected triazole pesticides could be taken up by rice roots, but their distribution in plant tissues was different. The accumulation of the three pesticides in rice root followed the order of epoxiconazole > tebuconazole > triadimefon, while a reversed order was observed in rice shoots. The movement of triazole pesticides within rice tissues involved both symplast and apoplast pathways, with triadimefon preferentially through the symplast pathway and epoxiconazole throughby the symplast pathway. The subcellular distribution reveals that all pesticides have a higher proportion in cell walls than in cell organelles and soluble components. Epoxiconazole has the highest accumulated capacity in the cell wall (45%-67%) and triadimefon was more concentrated in the soluble components (24%-29%). However, there exists no signi cant difference in the amount of three pesticides in cell organelles. The pesticide uptake, the movement of pesticides in symplast and apoplast, and the subcellular distribution of the three pesticides are related to the hydrophobicity of the three pesticides.

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Section: Introductionmentioning

confidence: 99%

Uptake, translocation, and subcellular distribution of three triazole pesticides in rice

Wang

et al. 2021

Environ Sci Pollut Res

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“…Some studies have demonstrated that triadimefon has toxic effects on zebra sh and xenopus, likehormone dyscrasia and reproductive problems (Ma et al, 2020, Zhang et al, 2020). Moreover, the metabolites of some pesticides, such as triadimefon and triadimenol, can induce cytotoxicity in human beings (Xu at al., 2020). Epoxiconazole is an inhibitor of 11 β-hydroxylase and aldosterone synthase, and prolonged exposure can cause cardiometabolic diseases, chronic kidney disease, mass, and immune-related disorders (Akram et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Uptake, Translocation and Subcellular Distribution of Three Triazole Pesticides in Rice

Wang

et al. 2021

Preprint

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Triazole pesticide is a widely-used pesticide for the control of pathogenic fungi in crops and its extensive use has caused food safety issues due to its uptake byedible crops. The residue of triazole pesticides has caused many toxicity risks and food safety problems. In this study, the uptake, translocation, and subcellular distribution of three triazole pesticides (triadimefon, tebuconazole, and epoxiconazole) in rice were investigated. The results showed that the three selected triazole pesticides could be taken up by rice roots, but their distribution in plant tissues was different. The accumulation of the three pesticides in rice root followed the order of epoxiconazole > tebuconazole > triadimefon, while a reversed order was observed in rice shoots. The movement of triazole pesticides within rice tissues involved both symplast and apoplast pathways, with triadimefon preferentially through the symplast pathway and epoxiconazole throughby the symplast pathway. The subcellular distribution reveals that all pesticides have a higher proportion in cell walls than in cell organelles and soluble components. Epoxiconazole has the highest accumulated capacity in the cell wall (45%-67%) and triadimefon was more concentrated in the soluble components (24%-29%). However, there exists no significant difference in the amount of three pesticides in cell organelles. The pesticide uptake, the movement of pesticides in symplast and apoplast, and the subcellular distribution of the three pesticides are related to the hydrophobicity of the three pesticides.

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“…Pesticides are biocidal substances which have been indispensably utilized in crop production for an effective fight against pests such as insects, fungi, herbs and mites 2 . Despite their large scale uses and economic benefits in agricultural areas, overexposure to various pesticides carries high risks for the environment and biota.As a multi-member pesticide family, triazoles have become one of the most commonly applied fungicides due to their effectiveness, systemic motion, wide spectrum, and versatile usage for suppressing plant diseases and yield loss due to pathogenic fungi 3,4 . Scientific efforts have focused on unwanted health risks on untargeted organisms caused by repeated and global employment of fungicides 5 .Diniconazole] is a triazole type with an excellent antifungal capacity in protection of fruits, vegetables, cereals and tea plants against several diseases through therapeutic and preventive practices 6 .…”

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confidence: 99%

“…It is classified as a systemic fungicide that functions in the inhibition of the ergosterol synthesis, particularly in 14α-demethylation step of the biosynthesis via lanosterol-14 α-ademethylase enzyme 6 . Xu et al 4 stated that its long half-life duration and highly lipophilic character let diniconazole fungicide have crucial risk potential for untargeted organisms. Although it is widely used in agricultural production processes, diniconazole was proven to be a suppressor for plant growth, chlorophyll synthesis and photosynthesis [8][9][10][11] .…”

mentioning

confidence: 99%

“…As a multi-member pesticide family, triazoles have become one of the most commonly applied fungicides due to their effectiveness, systemic motion, wide spectrum, and versatile usage for suppressing plant diseases and yield loss due to pathogenic fungi 3,4 . Scientific efforts have focused on unwanted health risks on untargeted organisms caused by repeated and global employment of fungicides 5 .…”

mentioning

confidence: 99%

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Preventive efficiency of Cornelian cherry (Cornus mas L.) fruit extract in diniconazole fungicide-treated Allium cepa L. roots

Macar

Yalçın

et al. 2021

Sci Rep

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Cornelian cherry (Cornus mas L.) is a medicinal plant with antioxidant-rich fruits. Diniconazole, a broad-spectrum fungicide, is employed extensively. The present study was designed to evaluate the preventive efficiency of C. mas fruit extract (CME) against the toxic effects of diniconazole on a model organism, Allium cepa L. For this aim, physiological, cytogenetic and biochemical parameters as well as the meristematic cell damages were investigated in A. cepa treated with diniconazole and C. mas extract. A. cepa bulbs were divided into six groups which were treated with tap water, 0.5 g/L CME, 1.0 g/L CME, 100 mg/L diniconazole, 0.5 g/L CME + 100 mg/L diniconazole and 1.0 g/L CME + 100 mg/L diniconazole, respectively. Diniconazole application caused a significant reduction in germination percentage, root elongation and total weight gain. Mitotic index decreased, while chromosomal aberrations increased following diniconazole application. Diniconazole caused significant rises in malondialdehyde content and the total activities of superoxide dismutase and catalase enzymes. The meristematic cell damages induced by diniconazole were indistinct transmission tissue, epidermis cell deformation, thickening of the cortex cell wall and flattened cell nucleus. Aqueous C. mas extracts induced a dose-dependent prevention and amelioration in all damages arisen from diniconazole application.

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Comparative cytotoxic effects of five commonly used triazole alcohol fungicides on human cells of different tissue types

Cited by 8 publications

References 40 publications

Uptake, translocation, and subcellular distribution of three triazole pesticides in rice

Uptake, translocation, and subcellular distribution of three triazole pesticides in rice

Uptake, Translocation and Subcellular Distribution of Three Triazole Pesticides in Rice

Preventive efficiency of Cornelian cherry (Cornus mas L.) fruit extract in diniconazole fungicide-treated Allium cepa L. roots

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