Comparative biochemical and behavioural effects of fencamfamine and dl-amphetamine in rats

Circadian time-dependent effects of fencamfamine on inhibition of dopamine uptake and release in rat striatal slices

“…These data indicate that FCF produces its effects predominantly by inhibition of dopamine reuptake, while amphetamine seems to act as a dopamine releaser (3). Behavioral studies in rats showed that FCF increases locomotion, rearing and sniffing, and also induces stereotyped behavior (4). These behavioral effects of FCF are similar to those of amphetamine and cocaine (3,5).…”

Circadian time-dependent effects of fencamfamine on inhibition of dopamine uptake and release in rat striatal slices

“…These data indicate that FCF produces its effects predominantly by inhibition of dopamine reuptake, while amphetamine seems to act as a dopamine releaser (3). Behavioral studies in rats showed that FCF increases locomotion, rearing and sniffing, and also induces stereotyped behavior (4). These behavioral effects of FCF are similar to those of amphetamine and cocaine (3,5).…”

New Drugs on the Internet: The Case of Camfetamine

“…Fencamfamine (FCF) is a psychostimulant that has complex effects in the central nervous system. Regarding acute effects, some studies suggest that FCF releases dopamine (DA) from both α -methyl-p-tyrosine and reserpine pools at dopaminergic cerebral nerve terminals [16]. FCF increased the homovanillic acid (HVA) levels in nucleus accumbens, tuberculum olfactorium, and corpus striatum and the dihydroxyphenylacetic acid (DOPAC) levels in the nucleus accumbens; on the other hand, amphetamine (AM) decreased the DOPAC levels in the 3 structures [16].…”

“…Regarding acute effects, some studies suggest that FCF releases dopamine (DA) from both α -methyl-p-tyrosine and reserpine pools at dopaminergic cerebral nerve terminals [16]. FCF increased the homovanillic acid (HVA) levels in nucleus accumbens, tuberculum olfactorium, and corpus striatum and the dihydroxyphenylacetic acid (DOPAC) levels in the nucleus accumbens; on the other hand, amphetamine (AM) decreased the DOPAC levels in the 3 structures [16]. These data indicate that FCF and AM may differ from each other on particular mechanisms by which catecholamines are released [17].…”

“…Preclinical studies showed that the behavioral effects of FCF include activation of locomotor, an increase in the stereotyped sniffing, and paradoxical decrease in rearing and behavior. At high doses, it induces stereotyped behavior [16]. It was also shown that FCF can act as a positive reinforcer and was hypothesized that opioid receptors mediate the reinforcing effects of FCF [25].…”

An improved synthesis of N-(3-phenylbicyclo[2.2.1]-yl)-N-ethylamine hydrochloride (Fencamfamine)

“…Fencamfamine is a compound structurally related to psychostimulants of the phenylalkylamine group, though it differs from these in that it has a different profile of pharmacological activity [4]. Fencamfamine has virtually no hypertensive activity and its mental effects are dose-dependent.…”

Circadian time-dependent effects of fencamfamine on inhibition of dopamine uptake and release in rat striatal slices

“…These data indicate that FCF produces its effects predominantly by inhibition of dopamine reuptake, while amphetamine seems to act as a dopamine releaser (3). Behavioral studies in rats showed that FCF increases locomotion, rearing and sniffing, and also induces stereotyped behavior (4). These behavioral effects of FCF are similar to those of amphetamine and cocaine (3,5).…”

New Drugs on the Internet: The Case of Camfetamine

“…Fencamfamine (FCF) is a psychostimulant that has complex effects in the central nervous system. Regarding acute effects, some studies suggest that FCF releases dopamine (DA) from both α -methyl-p-tyrosine and reserpine pools at dopaminergic cerebral nerve terminals [16]. FCF increased the homovanillic acid (HVA) levels in nucleus accumbens, tuberculum olfactorium, and corpus striatum and the dihydroxyphenylacetic acid (DOPAC) levels in the nucleus accumbens; on the other hand, amphetamine (AM) decreased the DOPAC levels in the 3 structures [16].…”

“…Regarding acute effects, some studies suggest that FCF releases dopamine (DA) from both α -methyl-p-tyrosine and reserpine pools at dopaminergic cerebral nerve terminals [16]. FCF increased the homovanillic acid (HVA) levels in nucleus accumbens, tuberculum olfactorium, and corpus striatum and the dihydroxyphenylacetic acid (DOPAC) levels in the nucleus accumbens; on the other hand, amphetamine (AM) decreased the DOPAC levels in the 3 structures [16]. These data indicate that FCF and AM may differ from each other on particular mechanisms by which catecholamines are released [17].…”

“…Preclinical studies showed that the behavioral effects of FCF include activation of locomotor, an increase in the stereotyped sniffing, and paradoxical decrease in rearing and behavior. At high doses, it induces stereotyped behavior [16]. It was also shown that FCF can act as a positive reinforcer and was hypothesized that opioid receptors mediate the reinforcing effects of FCF [25].…”

An improved synthesis of N-(3-phenylbicyclo[2.2.1]-yl)-N-ethylamine hydrochloride (Fencamfamine)

“…Fencamfamine is a compound structurally related to psychostimulants of the phenylalkylamine group, though it differs from these in that it has a different profile of pharmacological activity [4]. Fencamfamine has virtually no hypertensive activity and its mental effects are dose-dependent.…”

Circadian time-dependent effects of fencamfamine on inhibition of dopamine uptake and release in rat striatal slices

“…These data indicate that FCF produces its effects predominantly by inhibition of dopamine reuptake, while amphetamine seems to act as a dopamine releaser (3). Behavioral studies in rats showed that FCF increases locomotion, rearing and sniffing, and also induces stereotyped behavior (4). These behavioral effects of FCF are similar to those of amphetamine and cocaine (3,5).…”

New Drugs on the Internet: The Case of Camfetamine

“…Fencamfamine (FCF) is a psychostimulant that has complex effects in the central nervous system. Regarding acute effects, some studies suggest that FCF releases dopamine (DA) from both α -methyl-p-tyrosine and reserpine pools at dopaminergic cerebral nerve terminals [16]. FCF increased the homovanillic acid (HVA) levels in nucleus accumbens, tuberculum olfactorium, and corpus striatum and the dihydroxyphenylacetic acid (DOPAC) levels in the nucleus accumbens; on the other hand, amphetamine (AM) decreased the DOPAC levels in the 3 structures [16].…”

“…Regarding acute effects, some studies suggest that FCF releases dopamine (DA) from both α -methyl-p-tyrosine and reserpine pools at dopaminergic cerebral nerve terminals [16]. FCF increased the homovanillic acid (HVA) levels in nucleus accumbens, tuberculum olfactorium, and corpus striatum and the dihydroxyphenylacetic acid (DOPAC) levels in the nucleus accumbens; on the other hand, amphetamine (AM) decreased the DOPAC levels in the 3 structures [16]. These data indicate that FCF and AM may differ from each other on particular mechanisms by which catecholamines are released [17].…”

“…Preclinical studies showed that the behavioral effects of FCF include activation of locomotor, an increase in the stereotyped sniffing, and paradoxical decrease in rearing and behavior. At high doses, it induces stereotyped behavior [16]. It was also shown that FCF can act as a positive reinforcer and was hypothesized that opioid receptors mediate the reinforcing effects of FCF [25].…”

An improved synthesis of N-(3-phenylbicyclo[2.2.1]-yl)-N-ethylamine hydrochloride (Fencamfamine)

“…Fencamfamine is a compound structurally related to psychostimulants of the phenylalkylamine group, though it differs from these in that it has a different profile of pharmacological activity [4]. Fencamfamine has virtually no hypertensive activity and its mental effects are dose-dependent.…”