Comparative antiarrhythmic efficacy of amiodarone and dronedarone during acute myocardial infarction in rats

Reduction of Cerebral Infarct Size by Dronedarone

“…The decrease in heart rate by about 10% in response to the applied dronedarone dose (100 mg/kg body weight orally per day according to Agelaki et al [12] and Stoykov et al [13]) in our rat model served as a good indicator for comparison to human studies. In contrast, 30 mg/kg dronedarone per day had no effect on heart rate.…”

“…While improved cerebral perfusion might be in part responsible for the observed protective effect, the further reduction of cerebral infarct size in the presence of reduced aortic pressure at the higher dose of dronedarone suggests additional more direct mechanisms. Such neuroprotective effect of the multichannel inhibitor dronedarone could relate to its acute inhibition of the Na + /Ca 2+ -exchange system [2,12], potassium and/or sodium currents [5,13,25] which can contribute to reduced infarct size and brain edema during acute cerebral ischemia [26].…”

“…Referring to former experimental studies in rats using dronedarone, doses of 30 mg/kg body weight (low dose) and 100 mg/kg body weight (high dose) were used; the decrease in heart rate resulting from these doses in rats is comparable to doses of 400 and 800 mg dronedarone in humans [12,13]. Daily oral pretreatment was started 3 days before middle cerebral artery occlusion (MCAO) for 1 h followed by subsequent reperfusion using the established suture model.…”

Total Flavones of Choerospondias axillaris Attenuate Cardiac Dysfunction and Myocardial Interstitial Fibrosis by Modulating NF-κB Signaling Pathway

“…The sham group underwent thoracotomy and cardiac exposure without coronary ligation. The model establishment was confirmed by the occurrence of ST-segment elevation in electrocardiogram (ECG) [14]. Then, TFC was administrated at doses of 75, 150 and 300 mg/kg daily for 28 consecutive days (gavage).…”

“…The heart tissue sections were digitally imaged in high pixel resolution on an OLYMPUS DP25. Moreover, according to the method previously described [13][14][15], infarct size (IS) was calculated as total infarct circumference divided by total left ventricle circumference.…”