Comparative analysis of the 2016 ACR‐EULAR and the 2002 AECG classification criteria for Sjögren's syndrome: Findings from the NIH cohort

Billings, Monisha; Hadavand, Mohammad Amin; Alevizos, Ilias

doi:10.1111/odi.12772

Cited by 26 publications

(22 citation statements)

References 15 publications

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“…There is a high concordance between the previously published classification criteria and the 2016 ACR/EULAR criteria 28– 30 . However, an important change from older criteria is that the latest criteria give credit for the presence of an extraglandular manifestation.…”

Section: Selection Of Patients For Clinical Trialssupporting

confidence: 60%

Recent advances in the search for a targeted immunomodulatory therapy for primary Sjögren’s syndrome

Leverenz

Clair

2019

F1000Res

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Primary Sjögren’s syndrome is a chronic autoimmune disease characterized by salivary and lacrimal gland dysfunction, leading to substantial morbidity and reduced quality of life. Many patients with primary Sjögren’s syndrome also have extraglandular systemic complications, some of which can be organ- or life-threatening. Over the last decade, numerous targeted immunomodulatory therapies for primary Sjögren’s syndrome have failed to show a benefit in clinical trials, and as yet no disease-modifying therapy has been approved for this disease. Herein, we provide an updated review of the clinical trial landscape for primary Sjögren’s syndrome and the numerous efforts to move the field forward, including the development of new classification criteria and outcome measures, the results of recent clinical trials in this field, the challenges faced in the search for effective therapies, and the expanding pipeline of novel therapies under development.

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Section: Selection Of Patients For Clinical Trialssupporting

confidence: 60%

Recent advances in the search for a targeted immunomodulatory therapy for primary Sjögren’s syndrome

Leverenz

Clair

2019

F1000Res

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“…Subjects diagnosed with primary Sjögren's Syndrome (pSS) [18] were recruited through NIDCR Sjögren's…”

Section: Patient Population and Sampling Proceduresmentioning

confidence: 99%

Analysis of oral bacterial communities: comparison of HOMINGS with a tree-based approach implemented in QIIME

Palmer

Cotton²,

Kokaras³

et al. 2019

Journal of Oral Microbiology

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Background: Molecular taxonomic assignments in oral microbial communities have been made using probe-matching approaches, but never compared to those obtained by more readily accepted tree-based approaches. Objective: To compare community composition profiles obtained from a probe-matching approach (HOMINGS) to those from a closed-ended tree-based approach (QIIME using the eHOMD database). Design: HOMINGS and QIIME were used for parallel analysis of ten mock community samples, and of 119 supragingival plaque samples from ecologically unique sites (sound tooth surfaces in healthy subjects, sound tooth surfaces in patients with primary Sjögren's Syndrome, and carious lesions in Sjögren's Syndrome patients). Linear discriminant analysis Effective Size (LEfSe) was used to identify discriminating taxa among the natural plaque samples. Results: Community composition profiles of all samples were congruent between the two analysis aproaches. Alpha and beta diversity of the natural plaque communities were likewise similar. Communities from pSS patients and those from individuals with normal salivary flow differed in alpha and beta diversity. Both classification approaches yielded differences in composition predicted for samples from these subject cohorts, and discriminating taxa were similar between approaches. Conclusions: A direct comparison demonstrates that HOMINGS is largely equivalent to the tree-based approach as implemented here.

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“…60 These criteria were validated in cohort studies and showed a high level of agreement with earlier guidelines. [61][62][63][64]…”

Section: Clinical Featuresmentioning

confidence: 99%

Pulmonary and Bronchiolar Involvement in Sjogren's Syndrome

Chung

Wilgus

Fishbein

et al. 2019

Semin Respir Crit Care Med

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Sjogren's syndrome (SS) is a chronic autoimmune disease characterized by mononuclear cells (principally lymphocytes) infiltrating exocrine glands (e.g., salivary and lacrimal glands), leading to destruction of exocrine epithelial cells and dryness of mucosal surfaces. Cardinal symptoms are dry eyes (xerophthalmia) and dry mouth (xerostomia). Extraglandular sites are affected in 30 to 40% of cases of SS (particularly neurological, kidneys, skin, and lungs). B cell hyperactivity, autoantibody production, and hypergammaglobulinemia are cardinal features of SS. Primary SS is not associated with other autoimmune diseases. However, SS can complicate diverse autoimmune disorders (particularly systemic lupus erythematosus, rheumatoid arthritis, and scleroderma); this form is termed “secondary SS.” Pulmonary involvement is usually not a dominant feature of SS, but may be severe in some cases. In this review, we discuss specific tracheal, bronchiolar, and pulmonary complications of SS including xerotrachea, bronchiolitis, bronchiectasis, interstitial lung disease, nonspecific interstitial pneumonia, usual interstitial pneumonia, lymphoid interstitial pneumonia, organizing pneumonia, acute fibrinous and organizing pneumonia, pulmonary cysts, pleural effusions, pulmonary amyloidosis, and bronchus- or lung-associated lymphomas.

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Comparative analysis of the 2016 ACR‐EULAR and the 2002 AECG classification criteria for Sjögren's syndrome: Findings from the NIH cohort

Cited by 26 publications

References 15 publications

Recent advances in the search for a targeted immunomodulatory therapy for primary Sjögren’s syndrome

Recent advances in the search for a targeted immunomodulatory therapy for primary Sjögren’s syndrome

Analysis of oral bacterial communities: comparison of HOMINGS with a tree-based approach implemented in QIIME

Pulmonary and Bronchiolar Involvement in Sjogren's Syndrome

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