Comparative analysis of perinatal and postnatal factors, and general movement in extremely preterm infants

Zahed-Cheikh, Meriem; Brévaut-Malaty, Véronique; Busuttil, Muriel; Monnier, André; Roussel, Michel; Gire, Catherine

doi:10.1016/j.braindev.2010.10.023

Cited by 18 publications

(19 citation statements)

References 29 publications

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“…In line with other studies, infants with N-N trajectories had a limited incidence of perinatal comorbidities 33 , that could allow the emergence of normal pattern.…”

Section: Discussionsupporting

confidence: 89%

Early detection of general movements trajectories in very low birth weight infants

Porro

Fontana

Giannì

et al. 2020

Sci Rep

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The aim of the study was to investigate General Movements'(GMs) neonatal trajectories and their association with neurodevelopment at three months corrected age (CA) in preterm infants. We conducted an observational, longitudinal study in 216 very low birth weight infants. GMs were recorded at 31 ± 1, 35 ± 1, 40 ± 1 weeks of postmenstrual age and at three months of corrected age (CA). More than 90% of infants showing neonatal trajectories with persistent Normal (N-N) or initial Poor Repertoire to Normal (PR-N) movements presented fidgety pattern at three months CA. On the contrary, fidgety movements were not detected in any infant with a trajectory of persistent Cramped-Synchronized (CS-CS) or an initial Poor-Repertoire to Cramped-Synchronized (PR-CS) movements. Trajectories with initial Normal to Poor-Repertoire (N-PR) or persistent Poor-Repertoire (PR-PR) movements showed an increased risk of having a non-normal Fidgety pattern compared with the N-N group (OR = 8.43, 95% CI: 2.26-31.45 and OR = 15.02, 95% CI: 6.40-35.26, respectively). These results highlight the importance to evaluate neonatal GMs' trajectory to predict infants' neurodevelopment. N-N or PR-N trajectories suggest normal short-term neurodevelopment, especially a lower risk of Cerebral Palsy; whereas findings of N-PR and PR-PR trajectories indicate the need for closer follow up to avoid delay in programming intervention strategies.

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“…In line with other studies, infants with N-N trajectories had a limited incidence of perinatal comorbidities 33 , that could allow the emergence of normal pattern.…”

Section: Discussionsupporting

confidence: 89%

Early detection of general movements trajectories in very low birth weight infants

Porro

Fontana

Giannì

et al. 2020

Sci Rep

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“…This observation replicates findings by others who demonstrated that artificial ventilation was associated with deteriorating GMs or FMs [14,24]. An explanation for the deterioration of GMs/FMs in infants with prolonged mechanical ventilation might be the disruption of the integrity of cerebral white matter [25].…”

Section: Discussionsupporting

confidence: 87%

The Quality of General Movements after Treatment with Low-Dose Dexamethasone in Preterm Infants at Risk of Bronchopulmonary Dysplasia

Hitzert

Roescher²,

Bos³

2014

Neonatology

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Background: High-dose dexamethasone (DXM) treatment of preterms at risk of bronchopulmonary dysplasia leads to a deterioration in quality of their general movements (GMs). It is unknown whether low-dose DXM affects GM quality similarly. Objectives: To assess the effect of low-dose DXM treatment on the quality of GMs and fidgety GMs (FMs). Methods: A prospective study of preterms admitted to our NICU between 2010 and 2012, and treated with DXM (starting dose 0.25 mg/kg/day). We assessed GM/FM quality and calculated their motor optimality score (MOS) before, during, and after treatment up to 3 months postterm. Neurological follow-up was performed between 12 and 36 months. We related risk factors with infants' GM trajectories and MOSs. At 3 months we compared the MOSs of low-dose DXM infants and a historical cohort of infants treated with high-dose DXM or hydrocortisone. Results: 17 infants were included. GM/FM quality improved in 9 out of 13 initially abnormal infants (p = 0.004). Shorter periods of mechanical ventilation and higher birth weights were associated with better GM trajectories (p = 0.032 and p = 0.042, respectively). Infants starting treatment later had higher MOSs on day 7 (p = 0.047). Low-dose DXM infants had higher MOSs than high-dose DXM infants (β = -0.535; 95% CI -0.594 to -0.132; p = 0.003). Out of 17 infants, 2 died, 14 developed normally, and 1 developed with mild neurodevelopmental impairments. Infants whose GMs/FMs remained normal or improved had better outcomes than infants whose GMs/FMs remained abnormal (p = 0.019). Conclusions: Out of the 17 infants treated with low-dose DXM, 2 died. Of the surviving infants, neurological functioning improved with the majority having normal neurodevelopment at the age of 12-36 months.

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“…Touwen, Amiel-Tison, and Grenier) or a standard test of reflexes, tone, etc., were used to determine CP in 27 Review 483 studies. [16][17][18][38][39][40][41][42]44,45,48,[51][52][53][54][57][58][59]61,62,68,70,71,73,74,[78][79][80] Ten studies 13,43,46,50,63,64,67,72,76,77,85 used a non-specific neurological examination and were classified as unclear. Three studies 69,82-84 did not use standardized examinations between assessors and these were assigned a high risk of bias rating for the administration of the reference standard.…”

Section: Methodological Qualitymentioning

confidence: 99%

Predictive validity of spontaneous early infant movement for later cerebral palsy: a systematic review

Kwong

FitzGerald

Doyle

et al. 2018

Develop Med Child Neuro

155

134

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Comparative analysis of perinatal and postnatal factors, and general movement in extremely preterm infants

Cited by 18 publications

References 29 publications

Early detection of general movements trajectories in very low birth weight infants

Early detection of general movements trajectories in very low birth weight infants

The Quality of General Movements after Treatment with Low-Dose Dexamethasone in Preterm Infants at Risk of Bronchopulmonary Dysplasia

Predictive validity of spontaneous early infant movement for later cerebral palsy: a systematic review

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