Comparative analysis of EZH2, p16 and p53 expression in uterine carcinosarcomas
Evelin Makk,
Noémi Bohonyi,
Angéla Oszter
et al.
Abstract:Introduction: The role of p16 and p53 immunohistochemistry in the diagnosis of rare and aggressive uterine carcinosarcoma (UCS) has been well established. However, enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and a member of the polycomb group family is a relatively new biomarker, with limited published data on its significance in this tumor type. The goal of this study was to examine EZH2 expression in UCS and its components, in correlation with morphological features, and p16 and p53 stain… Show more
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