Comparación de Algoritmos Lineales y no Lineales para la Detección del Desacoplamiento Cardiorrespiratorio en Ratas Endotoxémicas

Abstract

Previous studies have shown that LPS-induced endotoxemia causes a cardiorespiratory (CRP) uncoupling owing to the physiological effects of systemic inflammation. Also, it is known that oxytocin has anti-inflammatory effects and cardioprotective properties; however, it is unknown whether it can modify the CRP coupling. This study aimed to compare different linear and nonlinear mathematics methods for the detection of cardiorespiratory uncoupling between cardiac and respiratory time series. The R-R time series of electrocardiograms of male rodents that were administered with saline solution (V); lipopolysaccharide (LPS); oxytocin (O) and LPS + oxytocin (LPS + Ox) were studied. We tested the R-R and respiratory series derived from the electrocardiogram (EDR) for the four groups to quantify the degree of coupling with cross-correlation; cross sample entropy; conditional entropy; mutual information; and Rényi's mutual information. We found that oxytocin does not seem to favor the CRP coupling during endotoxemia induced by LPS. Finally, we observed that the cross-sample entropy and the conditional entropy presented the highest statistical differences to identify the CRP uncoupling produced by LPS.

Changes in the autonomic cardiorespiratory activity in parturient women with severe and moderate features of preeclampsia

“…where α is used to find the divergence between two probability distributions, it is defined ∀ α ≠ 1. RMI depends on the α value; in this study, we explored α=2.5 ( 18 ). The denotes the Kullback Leibler divergence (KL divergence) between the joint probability and the product of the probability distribution of X and Y.…”

“…Promising evidence about the assessment of CRC as a relevant physiological mechanism has been reported in mental arithmetic and sustained attention ( 16 ), emotion characterization ( 17 ), and lipopolysaccharide-induced endotoxemia ( 18 ). In addition, the neuroinflammatory state of preeclampsia may be related to changes in nonlinear features of physiological signals ( 19 ).…”

Analysis of the fetal cardio-electrohysterographic coupling at the third trimester of gestation in healthy women by Bivariate Phase-Rectified Signal Averaging

“…However, it is unknown if that physiological coupling mechanism is also manifested earlier in the third trimester of pregnancy. It is also relevant to determine if other techniques, such as the cross-sample entropy and cross-correlation used to evaluate couplings in other physiological contexts [13,14], can detect significant FCEC couplings between EHG and FHR as well.…”