2019
DOI: 10.1136/bjophthalmol-2018-313277
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Abstract: AimTo determine the association between dementia and age-related macular degeneration (AMD) using meta-analysis.MethodsWe searched in the MEDLINE, EMBASE, Web of Knowledge, PsycInfo and Cochrane database of systematic reviews for studies published from March 1959 to March 2018. We included cross-sectional, case–control and cohort studies that evaluated the association of dementia/Alzheimer's disease (AD) with AMD (as outcome) and the association of AMD with dementia/AD (as outcome). Studies that compared cogni… Show more

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Cited by 27 publications
(43 citation statements)
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“…The Age‐Related Eye Disease Study (AREDS) and AREDS2 were multicenter phase III randomized clinical trials (RCT) designed to assess the effects of nutritional supplementation on progression to late age‐related macular degeneration (AMD) 24,25 . According to some epidemiologic studies and a meta‐analysis, AMD and dementia are associated at the population level 26,27 . Indeed, AMD and AD are both neurodegenerative conditions of aging and share some environmental risk factors, including smoking and hypertension; however, their genetic risk profiles are distinct 28–30 …”
Section: Introductionmentioning
confidence: 99%
“…The Age‐Related Eye Disease Study (AREDS) and AREDS2 were multicenter phase III randomized clinical trials (RCT) designed to assess the effects of nutritional supplementation on progression to late age‐related macular degeneration (AMD) 24,25 . According to some epidemiologic studies and a meta‐analysis, AMD and dementia are associated at the population level 26,27 . Indeed, AMD and AD are both neurodegenerative conditions of aging and share some environmental risk factors, including smoking and hypertension; however, their genetic risk profiles are distinct 28–30 …”
Section: Introductionmentioning
confidence: 99%
“…Together, these changes initiate an inflammatory response and deposition of drusen typical of AMD. A recent meta-analysis of 21 studies showed a significant association between AD and AMD [ 100 ], reinforcing the pathogenic role of Aβ in AMD.…”
Section: Methodsmentioning
confidence: 86%
“…Second, lower levels of high density lipoprotein can increase the risk of stroke, atherosclerosis and an inflammatory state, which are all related to dementia (41). Third, macular degeneration in the elderly has been associated with impaired cognitive function, AD, and dementia (42). Zeaxanthin is absorbed together with intestinal fat and transported to the retina by high-density lipoproteins, which can as antioxidants, limiting oxidative damage to the retina cells, exerting a protective effect against Age-related macular degeneration (43).…”
Section: Discussionmentioning
confidence: 99%