Comorbidity in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Nationwide Population-Based Cohort Study

Castro-Marrero, Jesús; Faro, Mònica; Aliste, Luisa; Sáez-Francàs, Naia; Calvo, Natàlia; Martínez-Martínez, Alba; Sevilla, Tomàs Fernández de; Alegre, José

doi:10.1016/j.psym.2017.04.010

Cited by 59 publications

(59 citation statements)

References 40 publications

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“…In 2003, a new clinical working case criterion for CFS/ME was put forward in the Canadian Consensus Document (Carruthers et al., ), and is a useful complement to the 1994 CDC/Fukuda definition. A recent study by our group reported a higher prevalence of co‐morbid conditions in CFS/ME than in non‐CFS/ME subjects (Castro‐Marrero et al., ).…”

Section: Introductionmentioning

confidence: 78%

Poor self‐reported sleep quality and health‐related quality of life in patients with chronic fatigue syndrome/myalgic encephalomyelitis

Castro-Marrero

Zaragozá

González-García

et al. 2018

Journal of Sleep Research

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Non-restorative sleep is a hallmark symptom of chronic fatigue syndrome/myalgic encephalomyelitis. However, little is known about self-reported sleep disturbances in these subjects. This study aimed to assess the self-reported sleep quality and its impact on quality of life in a Spanish community-based chronic fatigue syndrome/myalgic encephalomyelitis cohort. A prospective cross-sectional cohort study was conducted in 1,455 Spanish chronic fatigue syndrome/myalgic encephalomyelitis patients. Sleep quality, fatigue, pain, functional capacity impairment, psychopathological status, anxiety/depression and health-related quality of life were assessed using validated subjective measures. The frequencies of muscular, cognitive, neurological, autonomic and immunological symptom clusters were above 80%. High scores were recorded for pain, fatigue, psychopathological status, anxiety/depression, and low scores for functional capacity and quality of life, all of which correlated significantly (all p < 0.01) with quality of sleep as measured by the Pittsburgh Sleep Quality Index. Multivariate regression analysis showed that after adjusting for age and gender, the pain intensity (odds ratio, 1.11; p <0.05), psychopathological status (odds ratio, 1.85; p < 0.001), fibromyalgia (odds ratio, 1.39; p < 0.05), severe autonomic dysfunction (odds ratio, 1.72; p < 0.05), poor functional capacity (odds ratio, 0.98; p < 0.05) and quality of life (odds ratio, 0.96; both p < 0.001) were significantly associated with poor sleep quality. These findings suggest that this large chronic fatigue syndrome/myalgic encephalomyelitis sample presents poor sleep quality, as assessed by the Pittsburgh Sleep Quality Index, and that this poor sleep quality is associated with many aspects of quality of life.

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Section: Introductionmentioning

confidence: 78%

Poor self‐reported sleep quality and health‐related quality of life in patients with chronic fatigue syndrome/myalgic encephalomyelitis

Castro-Marrero

Zaragozá

González-García

et al. 2018

Journal of Sleep Research

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“…However, the following two tertiary care studies contained a large number of patients. In a review by Castro-Marrero et al [3] (n = 1757), 26% were employed and 63% were unable to work due to ME/CFS. In the aforementioned study by Collin et al [46] of the NHS database (n = 2170), this was 41% and 50%, respectively.…”

Section: Employment Status In Me/cfsmentioning

confidence: 99%

“…Patients with ME/CFS and Fibromyalgia (FM)-FM is a comorbidity in 50% to 60% of cases-are three times more likely to become non-improvers than those without FM [44]. Patients who are more ill and have comorbidities are less likely to be able to work than those with milder ME/CFS without comorbidities [3]. While there is good reason to suggest that a positive attitude will help in the prognosis of any disease, including ME/CFS, there is little empirical evidence to support the assertion that attitudes, behaviour or underlying personality have a major role in determining outcomes [54].…”

Section: Factors Predictive Of a Worse Outcomementioning

confidence: 99%

“…There is no diagnostic test, and treatment is based on symptom management. Symptoms occurring in more than 80% of cases are muscle weakness, generalized chronic pain, cognitive dysfunction-for example concentration or short-term memory impairments, difficulty with reading or information processing-hypersensitivity to noise and/or light, new onset headaches or migraines, joint pains, dizziness and episodes of postural orthostatic hypotension [3]. The number of ME literate medical doctors is limited due to the lack of teaching about this disease in medical school and post-graduate training [4].…”

Section: Introductionmentioning

confidence: 99%

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Work Rehabilitation and Medical Retirement for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients. A Review and Appraisal of Diagnostic Strategies

Vink¹,

Vink-Niese

2019

Diagnostics

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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome leads to severe functional impairment and work disability in a considerable number of patients. The majority of patients who manage to continue or return to work, work part-time instead of full time in a physically less demanding job. The prognosis in terms of returning to work is poor if patients have been on long-term sick leave for more than two to three years. Being older and more ill when falling ill are associated with a worse employment outcome. Cognitive behavioural therapy and graded exercise therapy do not restore the ability to work. Consequently, many patients will eventually be medically retired depending on the requirements of the retirement policy, the progress that has been made since they have fallen ill in combination with the severity of their impairments compared to the sort of work they do or are offered to do. However, there is one thing that occupational health physicians and other doctors can do to try and prevent chronic and severe incapacity in the absence of effective treatments. Patients who are given a period of enforced rest from the onset, have the best prognosis. Moreover, those who work or go back to work should not be forced to do more than they can to try and prevent relapses, long-term sick leave and medical retirement.

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“…Women with CFS/ME outnumber men 4:1 so hormonal issues maybe involved. 23 Many experience cyclical illness fluctuations or problems at menopause. Oestrogen has potentially positive effects in improving cerebral circulation, cognition, muscle and joint elasticity, relieving flushes and insomnia and can decrease immune overactivity.…”

Section: Cfs/me Should Be Managed In General Practicementioning

confidence: 99%

Guest Editorial: Chronic fatigue syndrome

Vallings¹

2019

J Prim Health Care

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Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a complex physical illness characterised by debilitating fatigue, post-exertional malaise and many other symptoms. Microglial activity in the brain is accompanied by chronic immune activation, changes in energy metabolism and abnormalities in the metabolome and microbiome. The illness was first described in the 18th century BC by Hammurabi, a Babylonian philosopher. Its history has been somewhat stormy. Charles Darwin and Florence Nightingale probably suffered from CFS/ME. Over the last century, outbreaks of viral illnesses have resulted in cohorts of people with serious ongoing health problems, which we now call CFS/ME. One of these cluster outbreaks occurred among medical staff at the Royal Free Hospital in London in 1955. Many remained very ill long-term. The name, 'Royal Free Disease' was coined. It was considered a serious physical illness, although in 1970 was re-labelled as 'mass hysteria'. 1 Patients' symptoms were not adequately investigated and much damage was done. Many still consider CFS/ME to be a psychiatric illness, despite research evidence to the contrary. In 1978, the Royal Society of Medicine concluded the illness had a clear organic basis. The World Health Organization's International Classification of Diseases (ICD-10) now classifies CFS/ME as a neurological illness (G93.3).

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Comorbidity in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Nationwide Population-Based Cohort Study

Cited by 59 publications

References 40 publications

Poor self‐reported sleep quality and health‐related quality of life in patients with chronic fatigue syndrome/myalgic encephalomyelitis

Poor self‐reported sleep quality and health‐related quality of life in patients with chronic fatigue syndrome/myalgic encephalomyelitis

Work Rehabilitation and Medical Retirement for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients. A Review and Appraisal of Diagnostic Strategies

Guest Editorial: Chronic fatigue syndrome

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