Comorbidity and survival in HIV-Infected men in the San Francisco Men's Health Survey

Page, Kimberly; DeLorenze, Gerald N.; Satariano, William A.; Winkelstein, Warren

doi:10.1016/s1047-2797(96)00064-6

Cited by 152 publications

(112 citation statements)

References 50 publications

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“…These findings are consistent with previous reports that recreational drug use was not associated with HIV disease progression in MSM [Chaisson et al, 1995;Di Franco et al, 1996;Kaslow et al, 1989;Page-Shafer et al, 1996]. A lack of association was also observed among injection drug users [Chaisson et al, 1995;Vlahov et al, 1998].…”

Section: Discussionsupporting

confidence: 92%

Recreational drug use and T lymphocyte subpopulations in HIV-uninfected and HIV-infected men

Chao

Jacobson

Tashkin

et al. 2008

Drug and Alcohol Dependence

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The effects of recreational drugs on CD4 and CD8 T cells in humans are not well understood. We conducted a longitudinal analysis of men who have sex with men (MSM) enrolled in the Multicenter AIDS Cohort Study to define associations between self-reported use of marijuana, cocaine, poppers and amphetamines, and CD4 and CD8 T cell parameters in both HIV-uninfected and HIV-infected MSM. For the HIV-infected MSM, we used clinical and laboratory data collected semiannually before 1996 to avoid potential effects of antiretroviral treatment. A regression model that allowed random intercepts and slopes as well as autoregressive covariance structure for within subject errors was used. Potential confounders adjusted for included length of follow-up, demographics, tobacco smoking, alcohol use, risky sexual behaviors, history of sexually transmitted infections, and antiviral therapy. We found no clinically meaningful associations between use of marijuana, cocaine, poppers, or amphetamines and CD4 and CD8 T cell counts, percentages, or rates of change in either HIVuninfected or -infected men. The regression coefficients were of minimum magnitude despite some reaching statistical significance. No threshold effect was detected for frequent (at least weekly) or continuous substance use in the previous year. These results indicate that use of these substances Correspondence and reprint request should be addressed to:

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Section: Discussionsupporting

confidence: 92%

Recreational drug use and T lymphocyte subpopulations in HIV-uninfected and HIV-infected men

Chao

Jacobson

Tashkin

et al. 2008

Drug and Alcohol Dependence

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“…Thus, specific impairments in NK cell function may compromise the host's natural resistance against HIV. These HIV effects on NK cell function, coupled with the reports of reduced NK cell activity in depression, including depressed HIV-infected individuals, could underlie the findings from studies suggesting that depression adversely affects HIV disease progression in prospective clinical investigations of HIV-seropositive individuals (11,13,14,17,18,(86)(87)(88).…”

Section: Discussionmentioning

confidence: 97%

“…Increasing evidence suggests that depression is a potential risk factor for the morbidity and mortality in other medical diseases, including HIV/AIDS (10)(11)(12)(13)(14)(15)(16)(17)(18)(19). Depression has been associated with alterations in cellular immunity, including NK cell numbers and NK cell cytotoxicity (20)(21)(22)(23)(24) in individuals who are depressed but without other medical illnesses.…”

mentioning

confidence: 99%

Selective Serotonin Reuptake Inhibitor and Substance P Antagonist Enhancement of Natural Killer Cell Innate Immunity in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome

Evans

Lynch

Benton

et al. 2008

Biological Psychiatry

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Background-Natural killer (NK) cells play an important role in innate immunity and are involved in the host defense against human immunodeficiency virus (HIV) infection. This study examines the potential role of three underlying regulatory systems that have been under investigation in central nervous system research as well as immune and viral research: serotonin, neurokinin, and glucocorticoid systems.

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“…21 HIV+ smokers also have lower CD4 cell counts, higher HIV viral loads, and lower self-reported quality of life than HIV+ nonsmokers. [19][20][21][22] Smokers are also more likely to progress to an AIDS diagnosis, 23 have poorer response to ART, 12 and are more likely to be nonadherent to ART. 24 Importantly, longer duration of abstinence from smoking substantially reduces HIV symptom burden.…”

Section: Smoking-related Morbidity and Mortality Among Plwhamentioning

confidence: 99%

Smoking Cessation for People Living With HIV/AIDS: A Literature Review and Synthesis

Ledgerwood

Yskes

2016

NICTOB

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Introduction: People living with HIV/AIDS (PLWHA) are more likely to smoke cigarettes than are individuals in the general population. The health implications of tobacco use are substantially more dire among PLWHA than among otherwise healthy smokers, including higher rates of various cancers, cardiovascular disease, inflammation, and lung infections. Efficacious behavioral and medication treatments for treating nicotine dependence have rarely been investigated in PLWHA. Methods: We present a review of studies examining the efficacy of smoking cessation interventions. Results and Conclusions:The literature reveals some limited evidence for the efficacy of behavioral interventions. However, the research literature on these interventions is sparse and the efficacy findings are mixed. Studies exploring the use of mobile technologies for reducing treatment barriers are becoming more prevalent. Few published trials have directly examined the efficacy of pharmacological smoking cessation interventions among PLWHA. Specific gaps in the treatment literature are discussed in detail, and a strategy is presented for developing a greater understanding of factors that contribute to the efficacy of smoking cessation among PLWHA. Implications: This paper provides the most comprehensive review to date on smoking cessation intervention research conducted with PLWHA. It also discusses specific gaps in the literature that should be a priority for future research.

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Comorbidity and survival in HIV-Infected men in the San Francisco Men's Health Survey

Cited by 152 publications

References 50 publications

Recreational drug use and T lymphocyte subpopulations in HIV-uninfected and HIV-infected men

Recreational drug use and T lymphocyte subpopulations in HIV-uninfected and HIV-infected men

Selective Serotonin Reuptake Inhibitor and Substance P Antagonist Enhancement of Natural Killer Cell Innate Immunity in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome

Smoking Cessation for People Living With HIV/AIDS: A Literature Review and Synthesis

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