2020
DOI: 10.1183/13993003.00547-2020
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Abstract: Background: The coronavirus disease 2019 outbreak is evolving rapidly worldwide. Objective: To evaluate the risk of serious adverse outcomes in patients with COVID-19 by stratifying the comorbidity status. Methods: We analysed data from 1590 laboratory confirmed hospitalised patients from 575 hospitals in 31 provinces/autonomous regions/provincial municipalities across mainland China between 11 December 2019 and 31 January 2020. We analysed the composite end-points, which consisted of admission to an intensiv… Show more

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Cited by 3,043 publications
(3,450 citation statements)
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References 34 publications
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“…Furthermore, according to our results, 10.89% of patients had chronic underlying diseases, mainly diabetes, chronic respiratory diseases , hypertension and cardiovascular diseases; this is similar to MERS-CoV [24]. In line with other studies [27][28][29] , our result also showed that, having comorbidities had a statistically significant effect on Mortality (OR=1.53, 95% CI: 1.04-2.24). A study suggested that compared to patients with no comorbidities, the risk of death in patients with influenza is more than in those who had cardiovascular disease and hypertension [30].…”
Section: Discussionsupporting
confidence: 90%
“…Furthermore, according to our results, 10.89% of patients had chronic underlying diseases, mainly diabetes, chronic respiratory diseases , hypertension and cardiovascular diseases; this is similar to MERS-CoV [24]. In line with other studies [27][28][29] , our result also showed that, having comorbidities had a statistically significant effect on Mortality (OR=1.53, 95% CI: 1.04-2.24). A study suggested that compared to patients with no comorbidities, the risk of death in patients with influenza is more than in those who had cardiovascular disease and hypertension [30].…”
Section: Discussionsupporting
confidence: 90%
“…= (2) where RFi is the relative infection fatality rate (or the rate ratio) for geographical unit i, Fi is the fatality rate (per 1,000) for a geographical unit and F is the fatality rate for the country.…”
Section: Methodsmentioning
confidence: 99%
“…Although hypertension and consequent exposure to ACEI and ARBS are likely common in severe COVID-19, this association does link to causality, as outlined above. [23][24] There may also be confounding by association here in that patients with severe COVID-19 are more likely to be 4 hypertensive, diabetic and older. This comorbidity burden rather than the associated drug therapy may better explain the adverse outcomes in coronavirus infection.…”
Section: Possible Benefits Of Raas Inhibitors In Patients With Covid-19mentioning
confidence: 99%