Comorbidities of Thyroid Disease in Children

Pimentel, Janiel; Chambers, Melissa; Shahid, Madhia; Chawla, Reeti; Kapadia, Chirag

doi:10.1016/j.yapd.2016.04.016

Cited by 4 publications

(1 citation statement)

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“…The female‐specific HR of hypothyroidism fell short of significance since owing to the small sample size of the female group, which renders the study underpowered to reveal significant differences. The higher burden of comorbidities in the group with coexistent AKN and thyroid diseases accords with the well‐established association of thyroid diseases with comorbid conditions 19,20 …”

Section: Discussionsupporting

confidence: 69%

Acne keloidalis nuchae and thyroid diseases: a population‐based cohort study

et al. 2020

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Background The association between acne keloidalis nuchae (AKN) and thyroid diseases is yet to be investigated. Objective To evaluate the risk of developing hypothyroidism and hyperthyroidism among patients with AKN and to characterize the patients who have AKN and thyroid comorbidities. Methods A population‐based cohort study was conducted comparing AKN patients (n = 2,677) with age‐, gender‐, and ethnicity‐matched control subjects (n = 13,190) with regard to incident cases of hypothyroidism and hyperthyroidism. Adjusted hazard ratios (HRs) were estimated by Cox regression analysis. Results The incidence rates of hypothyroidism among patients with AKN and controls were estimated at 2.15 (95% CI, 1.49‐2.99) and 0.82 (95% CI, 0.66‐1.00) cases/1000 person‐years, respectively. The crude risk of developing incident hypothyroidism was 1.85‐fold greater in patients with AKN (HR, 1.85; 95% CI, 1.24‐2.78; P = 0.003). The elevated risk persisted following the adjustment for putative confounders (adjusted HR, 1.72; 95% CI, 1.03‐2.89; P = 0.040). The risk of hyperthyroidism was comparable in patients with AKN and controls both in the crude (HR, 1.55; 95% CI, 0.57‐4.22) and adjusted (adjusted HR, 1.92; 95% CI, 0.59‐6.21) analyses. Patients with coexistent AKN and thyroid diseases were significantly older at the onset of AKN, had more prominent female preponderance, and had a higher burden of comorbidity. Conclusions Patients with AKN are at an increased risk of hypothyroidism. Screening for hypothyroidism should be considered in AKN patients with a compatible clinical picture.

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Section: Discussionsupporting

confidence: 69%