Community-based survey of HCV and HIV coinfection in injection drug abusers in Sichuan Province of China

Ruan, Yuhua; Hong, Kui; Liu, Shizhu; He, Yao; Zhou, Feng; Qin, Guan-Ming; Chen, Kanglin; Xing, Hui; Chen, Jianping; Shao, Yiming

doi:10.3748/wjg.v10.i11.1589

Cited by 34 publications

(25 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…High HCV prevalence and co-infection rate with HIV were observed previously among IDUs in some areas of China [4,12,16,18,20,28,30]. Here, we found that HCV prevalence were 81.6 and 69.9% among IDUs and all drug users in Zhenjiang, Jiangsu (Table 1), respectively, slightly lower than 88.5 and 75.5% in other neighbor cities of Jiangsu, respectively [5].…”

Section: Discussioncontrasting

confidence: 60%

High Prevalence of Hepatitis C virus Among Injection Drug Users in Zhenjiang, Jiangsu, China

Feng

et al. 2011

Indian J. Virol.

View full text Add to dashboard Cite

The constant increase in the number of drug users and rapidly spread of Hepatitis C virus (HCV) and Human immunodeficiency virus (HIV) among drug users result in a serious public health problem in China. To investigate HCV prevalence among drug users in Zhenjiang city, Jiangsu, China, 207 drug users from Zhenjiang were enrolled in this study during 2009 and the prevalence of HCV, HIV and syphilis infection were detected. HCV prevalence among injection drug users (IDUs) was 81.6%, significantly higher than that (22.9%) among oral drug users (P < 0.001), suggesting a strong association of HCV infection with injection drug use (IDU). Most drug users were more than 25 years old (89.2%), single (60.5%, including single and divorced/widowed), and had a history of drug abuse over 6 years (92.9%). HCV prevalence among drug users with middle (72.6%) or high (83.8%) school diplomas was significantly higher than that among those with lower (46.9%) education level (P = 0.007). HCV prevalence among IDUs did not obviously change along with the increase in duration of drug use and in frequency of injection per day, suggesting less association of HCV infection with both variables. These results suggest that most Chinese addicts might start drug use after their middle/high school education. To reduce drug use and to prevent HIV and HCV transmission via IDU, large-scale drug prevention educations should be urgently conducted in all China's middle and high schools.

show abstract

Section: Discussioncontrasting

confidence: 60%

High Prevalence of Hepatitis C virus Among Injection Drug Users in Zhenjiang, Jiangsu, China

Feng

et al. 2011

Indian J. Virol.

View full text Add to dashboard Cite

show abstract

“…Injection drug users (IDUs) are at increased risk for HBV, HCV and HIV infections through the mode of sharing injection equipment [27]. Studies have shown that coinfection with HCV can reach above 90 % in HIVinfected subjects [17,33,38], while in high-HBV-prevalence countries, the prevalence of HBV surface antigen (HBsAg) among IDUs has been shown to be 10-20 % [14]. East Asia is believed to have the largest populations of IDUs with viral hepatitis [14].…”

Section: Introductionmentioning

confidence: 99%

Hepatitis B virus and hepatitis C virus infection among HIV-1-infected injection drug users in Dali, China: prevalence and infection status in a cross-sectional study

et al. 2015

View full text Add to dashboard Cite

To assess the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and to investigate their mutual influences on infection status among human immunodeficiency virus type 1 (HIV-1)-seropositive injection drug users (IDUs). A cross-sectional study was conducted among HIV infected IDUs in Dali, China. The participants were tested for serological markers of HBV and HCV infection, alanine transaminase (ALT) activity and CD4(+) T cell count. HCV genotype was determined by sequencing. Of 529 patients, 498 (94.1 %) HIV infected IDUs agreed to participate. The overall prevalence of HCV infection (anti-HCV antibody positive) and spontaneous HCV clearance were 90.8 % (452/498) and 21.5 % (97/452), respectively. Of 411 subjects who had not received HBV vaccine, 296 (72.0 %) were positive for antibody against HBV core antigen (HBcAb), while 274 (66.7 %) were positive for both HCV antibody and HBcAb. HBV antigens were detected in 52 of the HBV-infected subjects (17.6 %). HCV clearance was associated with HBV antigenemia (p = 0.0002) and higher CD4(+) T cell count (p = 0.0294). Resolved HBV infection was associated with HCV genotype 3 (p = 0.0365). HBV and HCV infection are highly prevalent and mutually influence infection status in HIV-1 infected IDUs in Dali, China.

show abstract

“…Percutaneous exposures-including reuse of needles and syringes, injection drug use, and transfusion of unscreened blood products-are well-established risk factors. Two Chinese studies published in 2004 showed that 170% of injection drug users (IDUs) in Sichuan and Guangxi Provinces were seropositive for HCV antibodies [3,4], compared with 60% of IDUs in the United States [5]. In most industrialized countries, the risk of acquiring HCV infection through blood transfusion is now significantly reduced, because transfused blood is screened and risk behaviors in donors are identified.…”

mentioning

confidence: 99%

Hepatitis C Virus Infection in Former Commercial Plasma/Blood Donors in Rural Shanxi Province, China: The China Integrated Programs for Research on AIDS

et al. 2005

View full text Add to dashboard Cite

Background. Unsafe practices during illegal plasma donation in the late 1980s and early 1990s spread bloodborne infections in central China.Methods. A cross-sectional survey of a random sample of 538 adult residents of 12 villages in rural Shanxi Province, where there had been an illegal commercial plasma-collection center, was conducted in 2003. Structured questionnaires were administered, and blood samples were tested for hepatitis C virus (HCV) antibodies.Results. HCV seroprevalence rates were 8.2% in all subjects, 27.7% in former commercial plasma/blood donors, and 2.6% in nondonors. Selling blood or plasma was the strongest independent predictor of HCV seropositivity (odds ratio [OR], 14.4 [95% confidence interval {CI}, 7.1-31.6]). A history of blood transfusion was also independently associated with HCV seropositivity (OR, 8.3 [95% CI, 2.1-32.0]). Plasma donors had a higher risk of being HCV seropositive than did whole-blood donors (OR, 7.6 [95% CI, 2.9-20.9]), and female donors had a lower risk than did male donors (OR, 0.32 [95% CI, 0.12-0.80]). The strength of the association between selling blood and HCV seropositivity was weaker when plasma donors were excluded (OR, 8.0 vs. 14.4).Conclusions. Unsafe practices during illegal plasma donation led to a high risk of HCV seropositivity for donors during the 1980s and 1990s. Failure to screen for HCV increased the risk of seropositivity for transfusion recipients during this same period. China has taken steps to halt illegal plasma collection and to improve bloodbanking methods. However, there will be an ongoing challenge to care for patients with HCV infection, even as its incidence decreases.

show abstract

Community-based survey of HCV and HIV coinfection in injection drug abusers in Sichuan Province of China

Cited by 34 publications

References 27 publications

High Prevalence of Hepatitis C virus Among Injection Drug Users in Zhenjiang, Jiangsu, China

High Prevalence of Hepatitis C virus Among Injection Drug Users in Zhenjiang, Jiangsu, China

Hepatitis B virus and hepatitis C virus infection among HIV-1-infected injection drug users in Dali, China: prevalence and infection status in a cross-sectional study

Hepatitis C Virus Infection in Former Commercial Plasma/Blood Donors in Rural Shanxi Province, China: The China Integrated Programs for Research on AIDS

Contact Info

Product

Resources

About