volume 18, issue 4, P743-759 2004
DOI: 10.1016/j.idc.2004.07.004
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Richard G. Wunderink, Grant W. Waterer

Abstract: The present understanding of the pathophysiology of community-acquired pneumonia (CAP) explains the mechanism for many specific manifestations, but does not address adequately why only some patients experience complications. Recent advances in under-standing the genetics of complex illnesses offer hope for a more complete insight into the pathogenesis of CAP. This article reviews genetic variation in the molecules involved in the known patho-genic mechanisms of CAP, including cough, bacterial recognition, infl…

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