Communication is the key: biofilms, quorum sensing, formation and prevention

Preda, Veronica Georgiana; Săndulescu, Oana

doi:10.15190/d.2019.13

Cited by 95 publications

(47 citation statements)

References 76 publications

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“…This way of existence provides numerous benefits for microorganisms. Sessile cells interact with one another and communicate by the quorum sensing (QS) system, regulate gene expression and promote all the biological processes and activities useful to their survival within the surrounding environment [ 77 , 78 ]. This leads to an increased ability to withstand environmental stress (e.g., nutrient deprivation, oxygen limitation and pH changes) and to resist the immune system of the host and antimicrobial chemicals [ 79 , 80 , 81 , 82 ].…”

Section: Antiadhesive and Antibiofilm Activity Of Bssmentioning

confidence: 99%

Recent Advances in Biomedical, Therapeutic and Pharmaceutical Applications of Microbial Surfactants

et al. 2021

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The spread of antimicrobial-resistant pathogens typically existing in biofilm formation and the recent COVID-19 pandemic, although unrelated phenomena, have demonstrated the urgent need for methods to combat such increasing threats. New avenues of research for natural molecules with desirable properties to alleviate this situation have, therefore, been expanding. Biosurfactants comprise a group of unique and varied amphiphilic molecules of microbial origin capable of interacting with lipidic membranes/components of microorganisms and altering their physicochemical properties. These features have encouraged closer investigations of these microbial metabolites as new pharmaceutics with potential applications in clinical, hygiene and therapeutic fields. Mounting evidence has indicated that biosurfactants have antimicrobial, antibiofilm, antiviral, immunomodulatory and antiproliferative activities that are exploitable in new anticancer treatments and wound healing applications. Some biosurfactants have already been approved for use in clinical, food and environmental fields, while others are currently under investigation and development as antimicrobials or adjuvants to antibiotics for microbial suppression and biofilm eradication strategies. Moreover, due to the COVID-19 pandemic, biosurfactants are now being explored as an alternative to current products or procedures for effective cleaning and handwash formulations, antiviral plastic and fabric surface coating agents for shields and masks. In addition, biosurfactants have shown promise as drug delivery systems and in the medicinal relief of symptoms associated with SARS-CoV-2 acute respiratory distress syndrome.

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Section: Antiadhesive and Antibiofilm Activity Of Bssmentioning

confidence: 99%

Recent Advances in Biomedical, Therapeutic and Pharmaceutical Applications of Microbial Surfactants

et al. 2021

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“…The aforementioned 3-D structure is contributed to by the EPS (produced by the embedded cells), and they are also responsible for maintaining this architecture [ 32 ]. The maturation process involves cell-to-cell communication, in which cells embedded in the biofilm release signaling molecules called auto-inducers to facilitate quorum sensing [ 17 , 33 ]. Cells that receive the signals and then express their genes coding for EPS.…”

Section: Stages In Biofilm Formation and Its Developmentmentioning

confidence: 99%

Mechanisms and Impact of Biofilms and Targeting of Biofilms Using Bioactive Compounds—A Review

et al. 2021

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Biofilms comprising aggregates of microorganisms or multicellular communities have been a major issue as they cause resistance against antimicrobial agents and biofouling. To date, numerous biofilm-forming microorganisms have been identified, which have been shown to result in major effects including biofouling and biofilm-related infections. Quorum sensing (which describes the cell communication within biofilms) plays a vital role in the regulation of biofilm formation and its virulence. As such, elucidating the various mechanisms responsible for biofilm resistance (including quorum sensing) will assist in developing strategies to inhibit and control the formation of biofilms in nature. Employing biological control measures (such as the use of bioactive compounds) in targeting biofilms is of great interest since they naturally possess antimicrobial activity among other favorable attributes and can also possibly act as potent antibiofilm agents. As an effort to re-establish the current notion and understanding of biofilms, the present review discuss the stages involved in biofilm formation, the factors contributing to its development, the effects of biofilms in various industries, and the use of various bioactive compounds and their strategies in biofilm inhibition.

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“…), Streptococcus sp., Corynebacterium sp., Propionibacterium acnes (Gram-positive), Escherichia coli , Pseudomonas sp., Klebsiella pneumoniae , Providentia stuartii (Gram-negative), some fungi, and Mycobacterium sp. can form biofilms and thereby pose an increased risk of IAIs [ 16 , 17 ]. Previous studies have noted that cardiac implants could pose an increased risk of infections with up to 40% of ventricular assisted device (VAD) patients developing implant-related infections [ 18 , 19 ].…”

Section: Reviewmentioning

confidence: 99%