Common variants in TCF7L2 and CDKAL1 genes and risk of type 2 diabetes mellitus in Egyptians

El-Lebedy, Dalia; Ashmawy, Ingy

doi:10.1016/j.jgeb.2016.10.004

Cited by 21 publications

(19 citation statements)

References 37 publications

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“…[25][26][27][28]33 However, Dou et al 43 found there is no association between this SNP and T2DM in another Chinese population, which is consistent with the results in other populations. 28,39,44 In the current study, we also did not find an association between this SNP and T2DM in the Chinese population. The inconsistency was also found in the association of rs10946398 with T2DM, which was associated with T2DM in the current Chinese population, Chinese She, 45 and Russian 34 population, but not associated with T2DM in a Korean population.…”

Section: Discussioncontrasting

confidence: 77%

Association Between Single Nucleotide Polymorphisms in CDKAL1 and HHEX and Type 2 Diabetes in Chinese Population

Li¹,

Shen²,

Yang³

et al. 2021

DMSO

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Type 2 diabetes mellitus (T2DM) has a high global prevalence, and the interaction of environmental factors and genetic factors may contribute to the risk of T2DM. We aimed to investigate the association between T2DM and the single nucleotide polymorphisms (SNPs) in genes (CDKAL1 and HHEX) associated with insulin secretion. Subjects and Methods: T2DM (n=1,169) and nondiabetic (NDM) (n=1,277) subjects were enrolled and the eight SNPs in CDKAL1 and HHEX genes associated with insulin secretion were genotyped in a Chinese population using MassARRAY. Then, the association of these SNPs with T2DM was analyzed. Results: Our results revealed that four SNPs (rs4712524, rs10946398, rs7754840 in CDKAL1, and rs5015480 in HHEX) showed significantly different distributions between the T2DM and NDM groups (P<0.00625). The G allele of rs4712524 (P=0.004, OR=1.184; 95% CI=1.057-1.327), C allele of rs10946398 (P<0.001, OR=1.247; 95% CI=1.112-1.398), and C allele of rs775480 in CDKAL1 (P<0.001, OR=1.229; 95% CI=1.096-1.387) functioned as risk alleles of T2DM. The C allele of rs5015480 in HHEX (P<0.001, OR=1.295; 95% CI=1.124-1.493) was also the risk factor for T2DM. The haplotype analysis revealed that CDKAL1 haplotype rs4712524G-rs10946398C-rs7754840C-rs9460546G (P=0.001, OR=1.210; 95% CI=1.076-1.360) and HHEX haplotype rs1111875C-rs5015480C (P<0.001, OR=1.364; 95% CI=1.180-1.576) were the risk factors of T2DM. Conclusion:Our results revealed that genetic variations in CDKAL1 and HHEX were associated with T2DM susceptibility in Chinese population.

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Section: Discussioncontrasting

confidence: 77%

Association Between Single Nucleotide Polymorphisms in CDKAL1 and HHEX and Type 2 Diabetes in Chinese Population

Li¹,

Shen²,

Yang³

et al. 2021

DMSO

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“…COL8A1 , KCNQ1 , ALX4 , and HNF1 . TCF7L2 was the most widely reported gene in the region, in countries that include Palestine[ 54 ], Lebanon[ 55 ], UAE[ 56 ], Egypt[ 57 ], Qatar[ 58 ], and Tunisia[ 59 ]. In the Lebanese population, associations with T2D have been found with variants of the COL8A1 , KCNQ1 , ALX4 , and HNF1 genes[ 60 ].…”

Section: Risk Factorsmentioning

confidence: 99%

Epidemiology of type 2 diabetes in the Middle East and North Africa: Challenges and call for action

El‐Kebbi¹,

Bidikian²,

Hneiny³

et al. 2021

WJD

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Type 2 diabetes continues to be a serious and highly prevalent public health problem worldwide. In 2019, the highest prevalence of diabetes in the world at 12.2%, with its associated morbidity and mortality, was found in the Middle East and North Africa region. In addition to a genetic predisposition in its population, evidence suggests that obesity, physical inactivity, urbanization, and poor nutritional habits have contributed to the high prevalence of diabetes and prediabetes in the region. These risk factors have also led to an earlier onset of type 2 diabetes among children and adolescents, negatively affecting the productive years of the youth and their quality of life. Furthermore, efforts to control the rising prevalence of diabetes and its complications have been challenged and complicated by the political instability and armed conflict in some countries of the region and the recent coronavirus disease 2019. Broad strategies, coupled with targeted interventions at the regional, national, and community levels are needed to address and curb the spread of this public health crisis.

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“…CDKAL1 gene is located on chromosome 6p22.3 and encodes a 65-kD protein CDKAL1 which may be involved in beta cell dysfunction and T2DM susceptibility [14]. Evidence of this protein functioning also as a tRNA modification enzyme has been shown in some recent studies and activity of which is associated with ATP generation [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

CDKAL1 gene rs7756992 A/G and rs7754840 G/C polymorphisms are associated with gestational diabetes mellitus in a sample of Bangladeshi population: implication for future T2DM prophylaxis

Amin¹,

Parvez²,

Rahman³

et al. 2022

Diabetol Metab Syndr

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Background Association of single nucleotide polymorphisms (SNP) rs7756992 A/G and rs7754840 G/C of cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1 (CDKAL1) gene with the susceptibility of gestational diabetes mellitus (GDM) has been studied in a group of Bangladeshi women. Methods In this case–control study, 212 GDM patients and 256 control subjects were genotyped for rs7756992 and rs7754840 by PCR-RFLP and TaqMan™ allelic discrimination assay method respectively. Genotyping results were confirmed by DNA sequencing and replicated TaqMan™ assay. The odds ratios and their 95% confidence interval were calculated by logistic regression to determine the associations between genotypes and GDM. Results The genotype frequencies of rs7756992-AA/AG/GG in the GDM group and the control group were 37%/48%, 53%/45%, 10%/7% and those of rs7754840-CC/CG/GG were 51%/55%, 40.1%/39.8%, 9%/5% respectively. Under dominant and log additive models rs7756992 was revealed significantly associated with GDM after being adjusted for family history of diabetes (FHD) and gravidity. Conversely, rs7754840 was significantly associated (P = 0.047) with GDM only under the recessive model after the same adjustment. The risk allele frequency of both SNPs was higher in the GDM group but significantly (P = 0.029) increased prevalence was observed in the rs7756992 G allele. When positive FHD and risk alleles of these SNPs were synergistically present in any pregnant woman, the chance of developing GDM was augmented by many folds. The codominant model revealed 2.5 and 2.1 folds increase in odds by AG (rs7756992) and GC (rs7754840) genotypes and 3.7 and 4.5 folds by GG (rs7756992) and CC (rs7754840) genotypes respectively. A significant 2.7 folds (P = 0.038) increase in odds of GDM resulted from the interaction of rs7756992 and family history of diabetes under the dominant model. The cumulative effect of multigravidity and risk alleles of these SNPs increased the odds of GDM more than 1.5 folds in different genotypes. Conclusion This study not only revealed a significant association between rs7756992 and rs7754840 with GDM but also provided the possibility as potential markers for foretelling about GDM and type 2 diabetes mellitus in Bangladeshi women.

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Common variants in TCF7L2 and CDKAL1 genes and risk of type 2 diabetes mellitus in Egyptians

Cited by 21 publications

References 37 publications

Association Between Single Nucleotide Polymorphisms in CDKAL1 and HHEX and Type 2 Diabetes in Chinese Population

Association Between Single Nucleotide Polymorphisms in CDKAL1 and HHEX and Type 2 Diabetes in Chinese Population

Epidemiology of type 2 diabetes in the Middle East and North Africa: Challenges and call for action

CDKAL1 gene rs7756992 A/G and rs7754840 G/C polymorphisms are associated with gestational diabetes mellitus in a sample of Bangladeshi population: implication for future T2DM prophylaxis

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